Filtyp
Oligomerization of human cystatin C (HCC) leads to amyloid deposits in brain arteries, and this process is greatly accelerated with a naturally occurring L68Q variant. The crystal structures of N-truncated and full-length HCC (cubic form) showed dimer formation via three-dimensional (3D) domain swapping, and this observation has led to the suggestion that an analogous domain-swapping mechanism, bu
Background and Purpose— Adequate control of blood pressure (BP) is a cornerstone in stroke prevention. This study explored the risk of stroke in relation to the quality of BP control in a population-based cohort and whether control of hypertension was related to background characteristics of patients. Methods— A total of 27 936 subjects (10 953 men and 16 983 women), 45 to 73 years old, living in
1 We examined non-adrenergic, non-cholinergic (NANC) stimulation for its stabilizing effect on bronchial smooth-muscle tone with respect to its regulatory power and the effect of variations in neural impulse frequency. 2 The guinea-pig isolated main bronchus (n = 4-12) was pretreated with indomethacin (1O JAM) and incubated with atropine (1 pM) and guanethidine (10 JM). Electrical field stimulatio
Popular Abstract in Swedish Avhandlingen tar avstamp i en pågående internationell diskussion om kvinnors mänskliga rättigheter och islam. I denna diskussion kan olika muslimska ståndpunkter identifieras. En del avvisar mänskliga rättigheter, såsom dessa formulerats i internationella människorättsdokument, som ”västerländska” påfund och hävdar de religiösa källornas överordnade auktoritet. För andrThe dissertation focuses on interpretations of Islam that claim compatibility with international human rights norms in the context of women’s rights. These interpretations are seen as parts of an on-going contemporary international debate on women’s human rights and Islam that engages Muslims as well as non-Muslims. Existing UN-formulated international human rights schemes are a basic starting poi
Moraxella IgD binding protein (MID) is a novel bacterial outer membrane protein with IgD-binding properties. MID was purified from the respiratory pathogen Moraxella catarrhalis and is here shown to have B cell stimulatory properties. Purified MID in the range of 0.01-0.1 microg/ml was optimal to induce a proliferative response in human PBL. MID coupled to Sepharose and formalin-fixed M. catarrhal
We have used murine 3T3-L1 cells, which differentiate in culture and acquire morphological and biochemical features of mature adipocytes, as a model for studying the expression of cyclic-nucleotide phosphodiesterase (PDE) 3B activity, protein and mRNA during differentiation and during long-term treatment of the cells with tumour necrosis factor alpha (TNF-alpha), a cytokine associated with insulin
Exterior letter pairs (e.g., d_k in dark) play a major role in single-word recognition, but other research (D. Briihl & A. W. Inhoff, 1995) indicates no such role in reading text. This issue was examined by visually degrading letter pairs in three positions in words (initial, exterior, and interior) in text. Each degradation slowed reading rate compared with an undegraded control. However, whe
The effects of hormone and growth factor signaling on gene expression contribute significantly to breast tumorigenesis and disease progression; however, the targets of signaling networks associated with deregulated growth are not well understood. We defined the dynamic transcriptional effects elicited in MCF7, T-47D, and MDA-MB-436 breast cancer cell lines by nine regulators of growth and differen
In this report we will discuss the possibilities of defining a "good solution" of a system of linear equations. Ax=b where A is not necessarily quadratic. Especially the least squares problem will be treated. The concepts of pseudo inverses are introduced and its application to the least squares problem is shown. Geometrical interpretation of the solution in different cases is given. Different al
Universitetsläraren är för det mesta en pedagogisk amatör. En amatör är en "icke yrkesmässig utövare av något" men samtidigt en "älskare av något" (Wessén 1982). Med en lätt tolkning kan man alltså säga att en amatör utövar en verksamhet med kärleken som drivkraft. Detta kan då sättas i motsats till den professionelle utövaren som inte primärt har kärlek som drivkraft. En utvecklingstendens som i
Objectives. To compare perinatal and infant mortality in breech and cephalic presentations and between planned vaginal and cesarean section (CS) breech deliveries in Sweden. Methods. The study comprised two parts. Study A is a national cohort study for the period 1991-2001, including 22 549 breech presentations and 875 249 cephalic presentations born at >= 38 completed weeks. Study B is a case-con
Photon energy dependent intensity variations are experimentally observed in the L2,3M2,3M2,3 Auger spectra of argon clusters. Two cluster sizes are examined in the present study. Extrinsic scattering effects, both elastic and inelastic, involving the photoelectron are discussed and suggested as the explanation of the variations in the Auger signal. The atoms in the first few coordination shells su
Amperometric screen-printed biosensor arrays for detection of pesticides (organophosphates and carbamates) and phenols have been developed. Cholinesterases (AChE and BChE), tyrosinase (TYR), peroxidases (SBP. soybean and HRP. horseradish) and cellobiose dehydrogenase (CDH) were combined on the same array consisting of one Ag/AgCl reference electrode surrounded by eight radially distributed working
OBJECTIVE: Neuropeptide Y is a co-transmitter with noradrenaline in sympathetic neurons supplying arteries and veins with potent contractile effects. To investigate the role of neuropeptide Y in hypertension, we measured the circulating levels of neuropeptide Y and noradrenaline in patients with severe hypertension. DESIGN: Samples were collected from patients with untreated, severe hypertension (
This article presents reasons for undertaking "The Comparative Study of the Prevention of Crime and Violence by Mentally Ill Persons" and reasons for decisions regarding the study design and choice of measures. A brief portrait of the forensic patients that have been recruited is also presented. Community treatment programs could offer long-term cost-effective care for offenders with major mental
