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Roadmap for action on the environmental risk assessment of chemicals for insect pollinators (IPol-ERA)

Approaches integrating interdisciplinary perspectives are necessary to address current and future health and environmental challenges. Many policy initiatives have embraced more holistic approaches to tackle these challenges, e.g., the One Health concept, the Farm to Fork (F2F), Biodiversity and Chemical strategies within the European Green Deal and the global Sustainable Development Goals (SDGs).

Har du undermedvetna fördomar? : Ett interaktivt föredrag om jämställdhet på LTH

Undermedvetna könsstereotyper och fördomar påverkar jämställdheten i akademin, och även de som tror att de har en jämställd syn kan vara påverkade av dessa implicita bias. Kvinnor inom naturvetenskapliga ämnen både bedöms hårdare inom undervisning, bedömning, granskning och rekrytering och undervärderar sina egna akademiska förmågor vilket leder till en långsammare karriärsutveckling och i förläng

Rationale and design of the DAPA-MI trial : Dapagliflozin in patients without diabetes mellitus with acute myocardial infarction

Background: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. Methods: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or establishe

Interaction of Anisole on Alumina-Supported Ni and Mo Oxide Hydrodeoxygenation Catalysts

The conversion of biomass to transportation fuels and value-added chemicals is a promising method to reduce the reliance on fossil fuels. Mo-based catalysts have been shown to be highly active in the hydrodeoxygenation of biomass-derived phenolic compounds. The catalyst active phase, surface species, and the effect of adding additional metals are not comprehensively understood. Here we compare the

Ecosystem CO2 Exchange and Its Economic Implications in Northern Permafrost Regions in the 21st Century

Climate warming increases carbon assimilation by plant growth and also accelerates permafrost CO2 emissions; however, the overall ecosystem CO2 balance in permafrost regions and its economic impacts remain largely unknown. Here we synthesize in situ measurements of net ecosystem CO2 exchange to assess current and future carbon budgets across the northern permafrost regions using the random forest

What happened in the hinterland? : A batch study of early bucket-shaped pots from the 4th and 5th centuries AD in Southwest Norway.

Rogaland in southwest Norway was a core production area for bucket-shaped pottery throughout the ca. 200-year period spanned by these finds. Largely thanks to Elna Siv Kristoffersen's work we have a well-developed understanding of the final century of this characteristic Migration Period find: certain ceramic craft networks rose to prominence, culminating in workshop milieux intimately tied to the

Using academic work places to involve older people in the design of digital applications : presentation of a methodological framework to advance co-design in later life

Methods to involve users in design have long been used to create relevant content and increase the accuracy of product development. Demographic trends have raised the issue of the needs and demands of older people, especially with regard to digitization. In contrast to the high number of publications discussing the importance of involving people in the design of their daily life, very few publicat

Rational engineering of Luminiphilus syltensis(R)-selective amine transaminase for the acceptance of bulky substrates

Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki

Screening and Characterization of Novel Ulvan Degrading Lyases

Macroalgae are found worldwide dominating the aquatic ecosystems and representing a vast still sporadically explored resource with significant potential for mitigating climate change, constitute new food alternatives, provide sustainably fuel, and possibly be involved in new pharmaceutical discoveries. Despite limited research attention, ulvan, an irregular sulphated polysaccharide found in green

Subarctic winter warming promotes soil microbial resilience to freeze–thaw cycles and enhances the microbial carbon use efficiency

Climate change is predicted to cause milder winters and thus exacerbate soil freeze–thaw perturbations in the subarctic, recasting the environmental challenges that soil microorganisms need to endure. Historical exposure to environmental stressors can facilitate the microbial resilience to new cycles of that same stress. However, whether and how such microbial memory or stress legacy can modulate

Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden : An observational cohort study

Background: A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare. Methods: We assessed 231 patients

Multiclass risk models for ovarian malignancy : an illustration of prediction uncertainty due to the choice of algorithm

Background: Assessing malignancy risk is important to choose appropriate management of ovarian tumors. We compared six algorithms to estimate the probabilities that an ovarian tumor is benign, borderline malignant, stage I primary invasive, stage II-IV primary invasive, or secondary metastatic. Methods: This retrospective cohort study used 5909 patients recruited from 1999 to 2012 for model develo