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AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney dis
Hur ska en högre utbildning i säkerhetsledning se ut? Ska den ha utgångspunkt i teknik och problemlösning, ekonomi och management, kriminologi och beteendevetenskap eller kanske juridik? Här är del två i artikelserien om professionaliseringen av säkerhetsarbetet. Nu handlar det om möjligheter och utmaningar för en akademisk utbildning kring säkerhetsledning.
Treatment options for HIV patients have dramatically improved since the introduction of efficacious antiretroviral combination therapy more than a decade ago. Treatment regimens have been simplified with fewer pills and fewer daily dosages. Fosamprenavir is a protease inhibitor with a rather long half-life which makes it a candidate for once-daily use. Once-daily dosage of ritonavir-boosted fosamp
Mesenteric venous thrombus may be an incidental finding during imaging studies and asymptomatic patients are treated conservatively or with anticoagulant therapy only. Patients with symptomatic acute thrombosis causing bowel ischemia require urgent treatment, which frequently includes extensive surgery. Interventional treatment may be an alternative.
Amplification and overexpression of PPM1D (protein phosphatase magnesium-dependent 1 delta) has been observed in various cancer cell lines and primary tumors and has also been associated with cancers of poor prognosis. In addition to the negative feedback regulation of p38-p53 signaling, PPM1D inhibits other tumor suppressor activities and is involved in the control of DNA damage and repair pathwa
One regression test selection technique proposed for object-oriented programs is the Class firewall regression test selection technique. The selection technique selects test cases for regression test, which test changed classes and classes that depend on changed classes. However, in empirical studies of the application of the technique, we observed that another technique found the same defects, se
The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropat
A tabulation of binary systematic convolutional codes with an optimum distance profile for rates1/3and1/4is given. A number of short rate1/3binary nonsystematic convolutional codes are listed. These latter codes are simultaneously optimal for the following distance measures: distance profile, minimum distance, and free distance; they appear attractive for use with Viterbi decoders. Comparisons wit
BACKGROUND: The association between knee alignment and knee pain in knee osteoarthritis (OA) is unclear. High tibial osteotomy, a treatment option in knee OA, alters load from the affected to the unaffected compartment of the knee by correcting malalignment. This surgical procedure thus offers the possibility to study the cross-sectional and longitudinal association of alignment to pain. The aims
The effects of different parameters of interest for the localization of malignant tumours in situ by means of laser-induced fluorescence and haematoporphyrin derivatives were investigated. Such parameters are drug composition, drug concentration, laser pulse energy and excitation wavelength. In order to assess the relative merits of the two tumour-seeking agents Photofrin (haematoporphyrin derivat
I denna artikel beskrivs ett 7-plans kontorshus "Byggnad 800" byggt med pelare i stål och efterspända bjälklag i flytmedelsfri betong. Stomsystemet uppfyllde hyresgästen Sigmas krav på hög flexibilitet, såväl vad gällde planlösning som ventilation, el och VA. Stombyggnadstiden konkurrerade väl med ett renodlat system med förtillverkade element till följd av att kvarsittande plattbärlag användes bå
Inhibition of dipeptidyl peptidase 4 (DPP-4) is a novel treatment for type-2 diabetes. DPP-4 inhibition prevents the inactivation of glucagon-like peptide 1 (GLP-1), which increases levels of active GLP-1. This increases insulin secretion and reduces glucagon secretion, thereby lowering glucose levels. Several DPP-4 inhibitors are in clinical development. Most experience so far has been with sitag
An undergraduate course in Strategic Management seemingly provides similar basic content to students including the infamous SWOT (strengths, weaknesses, opportunities and threat) analysis along with the identification of functional level, business level, and generic strategies to enhance an organization’s competitiveness. One of the most common resources for this type of course is the article outl
This thesis is a study of configurations of identity in American mainstream comics. It focuses on how a small number of writers of Jewish descent have expressed or disciplined their Jewishness in relation to their creations. In an attempt to revise common linear narratives, the thesis presents three case studies of famous and influential comics texts with different primary foci: a chapter on SuperPopular Abstract in English The publication of Michael Chabon’s Pulitzer-prize winning novel The Amazing Adventures of Kavalier & Clay (2000) brought the Jewish–comics connection to popular attention. The novel illuminated the fact that many of the pioneers of American mainstream comics were Jewish. Owing to this history, and to the fact that there today exists a large and growing library of s
