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Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnor

Functional MRI (fMRI) using the blood-oxygen level dependent (BOLD) signal provides valuable insight into grey matter activity. However, uncertainty surrounds the white matter BOLD signal. Apparent diffusion coefficient (ADC) offers an alternative fMRI contrast sensitive to transient cellular deformations during neural activity, facilitating detection of both grey and white matter activity. Furthe

TAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregulation of metabolism and emotion is shared across these disorders and may be caused by hypothalamic pathology. Inclusions with TDP-43 are present in the hypothalamus in clinical ALS, as well as selective lo

Background: Coronavirus disease 2019 (COVID-19) pandemic constituted the largest global health crisis in recent generations. It may also have disrupted the pattern of antimicrobial use (AMU) and subsequently affected the development of antimicrobial resistance (AMR) – a grave human health concern. This study aimed to give an overview of existing AMR surveillance systems and evaluate the impact of

Luminescent properties of KTb(MoO4)2 and K5Tb(MoO4)4 crystals, possessing the same elemental composition but different crystal structures, were studied. The structural arrangement of Tb3+ ions, ordered in KTb(MoO4)2 and disordered in K5Tb(MoO4)4, determines their luminescence properties. Partial lattice disorder of K5Tb(MoO4)4 results in broadened bands of Tb3+ emission and excitation spectra, but

Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer

Contact allergy (CA) is not uncommon in the population, including to various fragrance allergens. If not diagnosed correctly, allergic contact dermatitis (ACD) may ensue, because targeted allergen avoidance is not possible. The primary objective of the study is to estimate the prevalence of CA to seven fragrance materials in patients with suspected ACD across Europe. Based on the outcome, a conclu

Background: Eating disorders significantly impact physical health and have negative psychosocial consequences. The global burden of anorexia nervosa and bulimia nervosa among young females is estimated to account for 1.9 million disability-adjusted life years. Early identification of disordered eating attitudes is critical for preventing the progression to more severe forms of eating disorders; ho

De kristnas historia i Mellanöstern under tvåtusen år.

This article analyses Swedish foreign policy from the early 1800s to the present day. A recurring theme centres on discussions about non-belligerence and neutrality, which have by no means been undisputed ideals. Additionally, the article explores the significant influence of Sweden’s historical experience, particularly the Swedish Great Power Era of the 17th and early 18th centuries, on shaping the

Like other societal institutions, academia today faces an existential crisis. Rising inequality and authoritarianism, coupled with climate breakdown and collapsing ecosystems, are threatening the conditions under which academic knowledge is produced and shared. At the same time, academics are coming to terms with their institutions’ role in contributing to these processes, particularly in the Glob

此次断资行为不仅反映日本对国际监督的不安，也可能鼓舞国内保守派更强烈反对性别平等改革。更令人担忧的是，日本似乎试图通过财政杠杆对国际机构施压。这无疑对它在人权和全球性别正义上的承诺构成挑战。