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Human Rights

Halme-Tuomisaari has written the definitions for keywords ‘Human Rights’, ‘International Humanitarian Law’ & ‘Monitoring Mechanisms’

Guarding utopia : Law, vulnerability and frustration at the UN Human Rights Committee

In the 1940s activists lobbied for the creation of a binding international bill of rights backed up by an international human rights court as the backbone of the post‐World War II order. Together, so the activists believed, these would guarantee peace and harmony to all mankind. Seven decades later this vision has been transformed into a cluster of UN human rights treaties and expert committees kn

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e.g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. Here we hypothesize that OGG1 may represent an attractive target to exploit reactive oxygen species (RO

Where’s the well : DNA evidence, personal narratives and unpredictability in Finnish family reunification

For people on the move, family reunification has become a major ‘channel’ to Europe and the ‘right to family’ is a widely recognized principle in international human rightsprotection and domestic legislations. Yet in practice exercising this ‘right’ is oftendifficult and migration buraucracies leave applicants unsure not only of the outcomeof their applications but of the criteria that are relied

Association between Apolipoprotein e ϵ2 vs ϵ4, Age, and β-Amyloid in Adults without Cognitive Impairment

Importance: Although the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of apolipoprotein E ϵ4 (APOE ϵ4) in Alzheimer disease and the ease of identifying ϵ4 carriers make the APOE genotype and its corresponding protein (apoE) an appealing therapeutic target to slow Aβ accumulation. Objective: To determine whethe

Impact of crystallite size on the performance of a beryllium reflector

Beryllium reflectors are used at spallation neutron sources in order to enhance the low-energy flux of neutrons emanating from the surface of a cold and thermal moderator. The design of such a moderator/reflector system is typically carried out using detailed Monte-Carlo simulations, where the beryllium reflector is assumed to behave as a poly-crystalline material. In reality, however, inhomogenei

Surface-associated lipid droplets : an intermediate site for lipid transport in human adipocytes?

Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined. In this study, we have characterized the presence of small surface-associated lipid droplets, distinct from the central droplet, in primary human adipocytes. Base