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The solvolysis of substituted benzoyl chlorides is sensitive both to substituent electronic effects and to medium effects. The solvolysis reactions of substituted benzoyl chlorides have been analyzed in the presence of nonionic micelles. The reaction is inhibited or catalyzed depending on the reaction mechanism, dissociative or associative, respectively. The micellar effects observed can be relate
Popular Abstract in Swedish Varje år drabbas i världen ca 3 miljoner individer av cancer i mag-tarmkanalen. Stora skillnader finns i incidens med magsäckscancer och matstrupscancer särskilt vanliga i utvecklingsländer, medan tjock- och ändtarmscancer är en av de vanligaste tumörtyperna i västvärlden. Cancer i mag-tarmkanalen ger ofta diffusa symtom, vilket i många fall leder till att tumörerna uppEsophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. This thesis aimed to genetically profile esophageal cancer with c
By using a Swern oxidation-epimerization-reduction sequence it is possible to selectively epimerize any position in isopropylidene-protected xylopyranosides, thus forming arabinosides, ribosides, and lyxosides. The driving force for epimerization of position 3 (xylo to ribo) is the release of ring strain by going from a 1,2-trans-acetal to a 1,2-cis-acetal.
Background: Sarcoidosis patients show dysregulated immune function, which may be related to subsequent cancer. We examined here the overall and specific cancer risks among Swedish subjects who had been hospitalized for sarcoidosis. Methods: A sarcoidosis research database was created by identifying hospitalized sarcoidosis patients from the Swedish Hospital Discharge Register and by linking them w
Den japanska byggsektorn är ofta ett föredöme för vår egen industris omvandling, t.ex. inom industrialisering och lean. Även när det gäller tillämpning och utveckling av Informations- och Kommunikations- Teknologi, ICT, t.ex. för BIM, ByggnadsInformationsModellering, har man mångårig avancerad erfarenhet som är intressant för oss att ta del av. Samtidig visar det sig att användningen och erfarenhe
Multiple exciton generation (MEG) is a process in which more than one exciton is generated upon the absorption of a high energy photon, typically higher than two times the band gap, in semiconductor nanocrystals. It can be observed experimentally using time resolved spectroscopy such as the transient absorption measurements. Quantification of the MEG yield is usually done by assuming that the bi-e
Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells. Here, we demonstrate that Dppa5 is a regulator of hematopoietic stem cells (HSCs) that critically governs reconstitution capacity after bone marrow transplantation. Ectopic expression of Dppa5 followed by in vitro culture robustly increased HSC reconstitution level
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance(1-3). In a genome-wide scan using 85,042 SNPs, we identified an association between SLE and a nonsynonymous substitution (rs10516487, R61H) in the B-cell scaffold protein with ankyrin repeats gene, BANK1. We replicated the association in four indepen
The metabolic syndrome is a clustering of several risk factors associated with diabetes and cardiovascular disease. Diabetes is a global problem with 90% of patients suffering from type 2 diabetes (T2D), which is attributable to various factors including genetic predispositions and lifestyle. In T2D, there is a reduction in β cell mass and function, and impaired glucose homeostasis. It is often as
Many studies have shown that female managers have to work harder than men to gain recognition, and that this often leads top female managers away from the leadership style characterized by soft skills and emotional understanding. Instead, another characterization can be seen; that of tough gendered machines fighting their way to the top - cyborgs. This article uses Haraway's metaphor of the cyborg
Popular Abstract in Swedish Huntingtons sjukdom (HS) är en ärftlig och dödlig sjukdom som karakteriseras av ofrivilliga, danslika rörelser vilket gjort att den i folkmun kallas för danssjuka. Diagnosen ställs när de motoriska problemen (ofrivilliga rörelserna) uppträder, vanligtvis i medelåldern, och dessa ökar sedan gradvis och den drabbade personen avlider på grund av sjukdomen efter cirka 15-25Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. The hypothalamus has emerged as an
Most fractures heal uneventfully but some evolve into nonunions. Autologous bone graft is the gold standard for stimulating healing. However, donor site morbidity, and limited graft supply make alternatives interesting. Bone Morphogenetic Proteins, BMPs, are growth factors involved in bone signaling. They are available in recombinant form for local application in nonunions and stimulate differenti
BACKGROUND: Frequent hyperglycemic episodes are increasingly being associated with an increased risk of type 2 diabetes and cardiovascular disease. OBJECTIVE: We studied the extent to which acute glycemia and glycemia after subsequent meals can be modulated by the characteristics of cereal foods, such as glycemic index (GI) and content of indigestible carbohydrates. DESIGN: Twelve healthy subjects
We report on single-crystal growth, and crystal structure of CuMn3As2 and Cu2Mn4As3 compounds. Magnetic properties of Cu2Mn4As3 were studied in temperature range between 2 and 400 K. The single crystals were prepared from bismuth flux and characterized by means of single crystals diffraction, electron-microprobe analysis, magnetic and resistivity measurements. Crystal structures of CuMn3As2 and Cu
The overall aim of this thesis was to investigate the initial diabetes education process, the impact on children and their parents and parental satisfaction with the care received one and two years subsequent to the child’s diagnosis. In order to seek a deeper understanding for how the diabetes team’s initial education process works from admission to discharge among families with a child newly dia
The high index (441) surface of bismuth has been studied using scanning tunneling microscopy (STM), angle resolved photoemission spectroscopy (APRES), and spin-resolved ARPES. The surface is strongly corrugated, exposing a regular array of (110)-like terraces. Two surface localized states are observed, both of which are linearly dispersing in one in-plane direction (k(x)), and dispersionless in th
Rapporten som er opdelt i fire delrapporter er udarbejdet i projektet ”ICT i byggesektoren – Netværk til udvikling”, som er delfinansieret af regionsudviklingsprojektet Interreg IIIA. ”ICT i byggesektoren – netværk til udvikling”. Projektet styrer mod, via et netværk om IKT omkring Øresund, at muliggøre bedre, billigere og mere miljørigtigt byggeri og boliger, ved at identificere og fjerne hindrin
The relationship between a reported history of trauma and dissociative symptoms has been explained in 2 conflicting ways. Pathological dissociation has been conceptualized as a response to antecedent traumatic stress and/or severe psychological adversity. Others have proposed that dissociation makes individuals prone to fantasy, thereby engendering confabulated memories of trauma. We examine data
