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A Catalyst pharmacophore model has been developed for the benzodiazepine site within the GABA(A) receptor complex. The model is based on a pharmacophore model originally proposed by Cook and co-workers (Drug Des. Discovery 1995, 12, 193-248) and further developed by Kahnberg et al. (J. Med. Chem. 2002,45, 4188-4201). The Catalyst pharmacophore model has been validated by using a series of flavonoi

The expression and distribution of mRNA encoding preproatrial natriuretic peptide (ppANP) in rat brain has been investigated by in situ hybridization of two 35S-labeled synthetic DNA oligonucleotides, based on a cDNA clone sequence that encodes rat ppANP. The highest relative concentrations of ppANP mRNA were detected in the medial preoptic hypothalamic nucleus ("anteroventral/third ventricle regi

Formation of DNA adducts as a result of exposure to polycyclic aromatic hydrocarbons (PAH) was studied in 98 potroom workers from an aluminium smelting plant and in 55 blue-collar workers without occupational PAH exposure. DNA from peripheral blood mononuclear cells (PBMC) was used for quantitation of individual PAH-DNA adducts by P-32-postlabelling/high performance liquid chromatography (HPLC) an

Direct scattering of propagating transient waves originating from internal sources in non-stationary, inhomogeneous, dispersive, stratified media is investigated. The starting point is a general, inhomogeneous, linear, first order 2 X 2 system of equations. Particular solutions are obtained, as integrals of fundamental waves from point sources distributed throughout the medium. First, resolvent ke

This paper presents a decision theory which allows subjects to account for the uncertainties of their probability estimates. This is accomplished by modelling beliefs about states of nature by means of a class of probability measures. In order to represent uncertainties of those beliefs a measure of epistemic reliability is introduced. The suggested decision theory is evaluated in the light of emp

The goal of the study is to cast light on the psychological factors behind the participation in nature conservation projects aiming to promote biodiversity. Two projects, wetland restoration and forest preservation, are examined through the framework of the VBN (Value-Belief-Norm) theory. A survey was conducted among 120 farmers and 160 forest owners in southern Sweden. Results did not support the

On Sufi gatherings in London and the impact of a visiting shaykh.

Females of the European pine sawfly, Neodiprion sertifer (Geoffr) (Hymenoptera: Diprionidae), were released and observed inside and outside (=control) of areas treated with their sex pheromone for the purpose of mating disruption. In 1992 and 1993, respectively, 0 and 2.5% of the females were observed mating in the pheromone treated area during the first day compared with 28 and 26% in the control

The effect of the spatial distribution of hydrophobic surface residues on the adsorption of a weakly hydrophobic polymer to proteins has been examined using a coarse-grain model solved by Monte Carlo simulations. A given number of surface sites were distributed randomly on the protein surface subjected to a distance constraint. Five protein classes for which the minimum distance between the sites

The inclusive production of D*+/-(2010) mesons in deep-inelastic scattering is studied with the HI detector at HERA. In the kinematic region 1 < Q(2) < 100 GeV2 and 0.05 < y < 0.7 an e(+) p cross section for inclusive D*+/- meson production of 8.50 +/- 0.42(stat.)(-100)(+1.21)(syst.) nb is measured in the visible range p(tD*) > 1.5 GeV and eta(D*) < 1.5. Single and double differential inclusive D*

New, precise abundance data for a large number of elements in a growingsample of extremely metal-poor stars are accumulating from the new 8-mtelescopes. Combined with theoretical models, these results advance ourunderstanding of the first generations of stars, whose nucleosynthesisproducts are fossilised in the oldest stars we see today and thus giveclues to the earliest phases of evolution in the

The accuracy and precision of frameless neuronavigation as compared to conventional frame-based stereotaxy for implantation of deep brain stimulation (DBS) electrodes were studied in 14 patients with essential tremor. DBS electrodes were implanted bilaterally in the ventrolateral thalamus [ventrointermediate nucleus ( VIM)] in one procedure. Frameless neuronavigation was used on one side and the c

Different methods of preventing delamination in impulse drying are discussed, and a new method to avoid delamination is presented. The method is based on maintaining a low hydraulic pressure in the paper web. This gives a low temperature in the web, and the corresponding vapor pressure is not sufficient to delaminate the paper web. Experiments were made on a nip simulator to determine the critical

This article presents the results of a study evaluating the International Safety Management (ISM) Code’s effects on vessel performance in port state control (PSC) inspections in Swedish ports. PSC statistics are compared and analyzed between vessels that were required to implement the Code by 1998 and vessels that were not. Additionally, the results of a survey and interviews of Swedish PSC inspec