Astrocytes are emerging key players in neurological disorders. However, their role in disease etiology is poorly understood owing to inaccessibility of primary human astrocytes. Pluripotent stem cell-derived cells fail to mimic age and due to their clonal origin do not mimic genetic heterogeneity of patients. In contrast, direct conversion constitutes an attractive approach to generate human astro

Context: It is unclear to what extent the plasma proteome of abdominal fat distribution differs from that of body mass index, and whether the differences have clinical implications. Objective: To evaluate the difference between the plasma proteomic profiles of body mass index (BMI) and waist-to-hip ratio (WHR), and then examine the identified BMI- or WHR-specific proteins in relation to incidence

It is reported that the China–Pakistan Economic Corridor has been affected by extreme precipitation events. Since the 20th century, extreme weather events have occurred frequently, and the damage and loss caused by them have increased. In particular, the flood disaster caused by excessive extreme precipitation seriously hindered the development of the human society. Based on CRiteria Importance Th

Fast transient events, such as the disintegration of liquid bodies or chemical reactions between radical species, involve various processes that may occur at different time scales. Currently, there are two alternatives for monitoring such events: burst- or high-speed imaging. Burst imaging at ultrahigh speeds (∼100 MHz to THz) allows for the capture of nature's fastest processes but only for a nar

This paper presents a novel enterprise architecture concept for mapping business capabilities called the Milky Way. It aims to create an anchoring image that can be used to communicate with various stakeholders. We look at examples from research data management and student administration. All the presented projects, from different universities, were highly successful in achieving stakeholder buy-iThis paper presents a novel enterprise architecture concept for mapping businesscapabilities called the Milky Way. It aims to create an anchoring image that can be used to communicate with various stakeholders. We look at examples from research data management and student administration. All the presented projects, from different universities, were highly successful in achieving stakeholder buy-in

Arctic and subarctic areas have experienced a rapid warming and substantial increases in precipitation in recent decades. The frequency and intensity of some extreme events, such as fires, winter warming events, extreme rainfall, and droughts, has also increased. These climatic changes and other anthropogenic factors have caused profound changes in arctic and subarctic ecosystems with important im

Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery. We performed a side-by-side comparison of how inactivation of each of these genes aff

In this paper we look at the adaption of SI-PASS programmes during the COVID-19 pandemic drawing from four Higher Education Institutions (HEIs) as case studies: The National University of Ireland (NUI) Galway in Ireland, Nord University in Norway, Lund University in Sweden and the University of Manchester in the UK. The paper also focuses on the role of SI-PASS in student engagement in an extraord

Altered sensory processing has been linked to symptoms of obsessive-compulsive disorder (OCD) and anxiety disorders (ADs) in youth, but few studies have examined sensory processing in clinical samples and no study has analyzed self-report data from youth meeting diagnostic criteria for OCD or ADs. This study included 86 youth with OCD, 82 youth with ADs, and 46 youth without psychiatric disorders.

At the Museum of World Culture (former Etnografiska Museet i Göteborg) there is an archaeological collection from the Santa Maria and Calchaqui Valleys of north-western Argentina, which came to the museum in 1930. In this article we will focus on six well-preserved objects with provenience from Quilmes and La Quebrada del Carmen in the Santa Maria Valley. In addition to the good conservation of th