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Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes

The system that regulates insulin secretion from beta-cells in the islet of Langerhans has a capsaicin-sensitive inhibitory component. As calcitonin gene-related peptide (CGRP)-expressing primary sensory fibers innervate the islets, and a major proportion of the CGRP-containing primary sensory neurons is sensitive to capsaicin, the islet-innervating sensory fibers may represent the capsaicin-sensi

A stratigraphically significant conodont fauna from the base of the Tetragraptus approximatus Zone at Holsbrotten, Mt. Hunneberg, SW Sweden

A diverse conodont collection representing the Oelandodus elongatus-Acodus deltatus deltatus Subzone of the Paroistodus proteus Zone has been retrieved from a sample from the E bed at Holsbrotten on the west side of Mt. Hunneberg. This bed marks the base of the Tetragraptus approximatus Zone at the nearby Diabasbrottet section, the recently ratified stratotype for the base of the Second Global Sta

A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2)

Streptomyces coelicolor A3(2) undergoes at least two kinds of cell division: vegetative septation leading to cross-walls in the substrate mycelium; and developmentally regulated sporulation septation in aerial hyphae. By isolation and characterization of a non-sporulating ftsZ mutant, we demonstrate a difference between the two types of septation. The ftsZ17(Spo) allele gave rise to a classical wh

The role of microorganisms in biliary tract disease.

The biliary tract is normally sterile, but bile-tolerant bacteria are frequently isolated from patients with cholecystitis. Since the identification of about 25 Helicobacter species, some of which may grow in bile, studies have addressed the role of these organisms in primary biliary cirrhosis, primary sclerosing cholangitis, and cholelithiasis. Most of these bacteria show the presence of Helicoba

Determination of free copper concentrations in natural waters by using supported liquid membrane extraction under equilibrium conditions

A method is described for measurement of freely dissolved copper concentrations in natural water samples using supported liquid membrane (SLM) extraction under equilibrium conditions, a technique denoted "equilibrium sampling through membranes" (ESTM). For this purpose, 1,10-dibenzyl-1,10-diaza-18-crown-6 as neutral carrier and oleic acid were used in the membrane phase. The main variables optimis

Equatorial Baltica in the Vendian: palaeomagnetic data from the Sarek Dyke Swarm, northern Swedish Caledonides

In this paper, we present Vendian palaeomagnetic data for continent Baltica, based on results from the 608 +/- 1 Ma old Sarek Dyke Swarm in northern Sweden. The dykes sit in the Sarektjahkka Nappe of the Seve Nappes, which were thrust eastwards over the Baltic craton during the early Palaeozoic Caledonian Orogeny. In spite of long transport distances as well as deformation and metamorphism in the

Pathogenomics: An updated European Research Agenda

The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typ

Hybrid Modelling of Homogeneous Charge Compression Ignition (HCCI) Engine Dynamics—A Survey

The Homogeneous charge compression ignition (HCCI) principle holds promise to increase efficiency and to reduce emissions from internal combustion engines. As HCCI combustion lacks direct ignition timing control and auto-ignition depends on the operating condition, control of auto-ignition is necessary. Since auto-ignition of a homogeneous mixture is very sensitive to operating conditions, a fast

Late Quaternary landscape and vegetation diversity in a North European perspective

The rarefaction technique applied to fossil pollen sequences for analyzing palynological richness, interpreted as a signal of biological diversity of landscapes and vegetation, has been developed since 1988. Errors including population evenness and vegetation disturbance have been considered in this study. Information from two sites is discussed, one with a pollen diagram covering Late-Glacial (La

Experimental nerve compression and upregulation of CPON in DRG

Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG and cell proliferation (incorporation of BrdU) in sciatic nerve of rats following chronic nerve compression (silicone tubes with different internal diameters) was studied by immunocytochemistry. An increased number of CPON-positive neurons and cells incorporating BrdU was induced on the compressed side, most pronounced when

Comprehension and production of relative clauses: a comparison between Swedish impaired and unimpaired children

The aim of the present study is to investigate the relationship between language comprehension and language production in Swedish children. This was done longitudinally with 10 children with specific language impairment (SLI), aged 4;0 to 6;3 at Time I, and 10 children with unimpaired language development, aged 3;1 to 3;7 at Time I. The target structure was subordination, more precisely relative c

Protein crystals can be incommensurately modulated

For a normal periodic crystal, the X-ray diffraction pattern can be described by an orientation matrix and a set of three integers that indicate the reciprocal lattice points. Those integers determine the spacing along the reciprocal lattice directions. In aperiodic crystals, the diffraction pattern is modulated and the standard periodic main reflections are surrounded by satellite reflections. Th

Bone density 11 years after anorexia nervosa onset in a controlled study of 39 cases

Objective To evaluate bone mineral density (BMD) and body composition 11 years after the onset of anorexia nervosa (AN). Method Thirty-nine AN subjects (36 females, 3 males), selected from a population-based sample, and 46 matched controls (COMP; 43 females, 3 males) were examined by using double-energy X-ray absorptiometry (DXA). Only 2 women still had AN. None of the men had AN. Results T

Decision makers and the usefulness of research evidence in policy implementation: a case study from Lao PDR

The involvement of researchers in the policy process and policy-makers in research is little studied, particularly in developing countries. In 1993, the Lao National Drug Policy (NDP) was endorsed in a consultative process involving many stakeholders. Lao People's Democratic Republic is a poor country in South East Asia. Five pilot provinces were selected for implementation of the policy, which ha