Hematopoietic stem cells (HSCs) are maintained in hypoxic niches in endosteal regions of bones. Here we demonstrate that Cripto and its receptor GRP78 are important regulators of HSCs in the niche. Flow cytometry analyses revealed two distinct subpopulations of CD34(-)KSL cells based on the expression of GRP78, and these populations showed different reconstitution potential in transplantation assa

The article explores issues concerning the reconfiguration of human and animal bodies in modern biotechnology. The examples are based on xenotransplantation: Transplantation of cells, tissue and organs from animals to humans. Three thematic issues that emerged from xenotransplantation research in Sweden in the 1990s and early 2000s are examined in the article. The first issue concerns how the pig

Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein

We compute the Cramér–Rao lower bounds for determination of isotropic permittivity and permeability in slabs using reflection and transmission data. The results apply to three common measurement situations: free space, rectangular waveguides, and coaxial waveguides. The bounds depend only on the available data and not on the actual inversion method used, making them suitable to evaluate a particul

Aging causes profound effects on the hematopoietic stem cell (HSC) pool, including an altered output of mature progeny and enhanced self-propagation of repopulating-defective HSCs. An important outstanding question is whether HSCs can be protected from aging. The signal adaptor protein LNK negatively regulates hematopoiesis at several cellular stages. It has remained unclear how the enhanced sensi

The article outlines the early origin and later transformations of Medieval Archaeology to Historical Archaeology, both as an antiquarian practice and as an academic subject, focusing on the development in Sweden since the 17th C.

Disease trend studies based on birth cohort analysis and serological studies indicate that recent generations have a higher prevalence of oncogenic Human Papilloma Virus (HPV) types, and are likely to be at higher risk of cancer than previous generations. This implies that prevention strategies to protect young populations from HPV-associated cancers need to be strengthened, and hence organized im

We investigated whether exposing a wound-healing-sensitive cell line to human wound fluid (HWF) could prime the cells to increase their tumor-forming ability in nude mice and, if so, whether this ability can be inhibited by pharmacological substances.

Topic: This paper reviewed the current literature regarding time use among people with psychiatric disabilities. Purpose: The purpose was to investigate what characterizes time use, occupational balance and occupational patterns among people with psychiatric disabilities, how time use relates to health in this group, and how time use can be used in research designs and addressed in assessments and

BACKGROUND: Boswellic acid is a type of triterpenoids with antiinflammatory and antiproliferative properties. Sphingomyelin metabolism generates multiple lipid signals affecting cell proliferation, inflammation, and apoptosis. Upregulation of acid sphingomyelinase (SMase) has been found in several inflammation-related diseases such as inflammatory bowel diseases, atherosclerosis, and diabetes. MET

Developing correlations between various soil parameters are considered the major challenge to diminish time and cost associated with field measurements. Soil hydraulic and physical properties were extensively characterized using tension disc infiltrometer and soil sampling in a silty clay agricultural field in Kalaat El-Andalous, Tunisia. Tension disc infiltrometer experiments were conducted at 10

The hypothesis of this thesis is that climate models should take structural vegetation changes that operate on interannual to centennial time scales into account in order to simulate climate change in a more realistic manner. To evaluate this hypothesis, a regional Earth System Model (ESM) has been developed, validated and applied over Europe. The model has enabled the identification of a number o