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Effect of charge on microvascular permeability in early experimental sepsis in the rat.

A key feature of sepsis is hypovolemia due to increased microvascular permeability. It has been suggested that the negative charge of albumin and of the endothelial glycocalyx is important for maintenance of the normally low permeability for albumin. Here we tested the hypothesis that charge effects contribute to the increased permeability in sepsis. Transcapillary escape rate (TER) and initial di

The probability of readmission within 30 days of hospital discharge is positively associated with inpatient bed occupancy at discharge - a retrospective cohort study.

Previous work has suggested that given a hospital's need to admit more patients from the emergency department (ED), high inpatient bed occupancy may encourage premature hospital discharges that favor the hospital's need for beds over patients' medical interests. We argue that the effects of such action would be measurable as a greater proportion of unplanned hospital readmissions among patients di

Navigating the market of welfare services: The choice of upper secondary school in Sweden

Due to increased market orientation and deregulation, welfare services in Sweden have taken on the form of market-based services. The body of research on deregulation and privatization is quite substantial regarding the implications of this kind of development. However, studies of the actual process of how choices are made are less common. This article discusses the implications of greater freedom

Minimization of label usage in (G) MPLS network

The paper considers a problem of minimizing the total number of labels that are necessary to realize a given set of end-to-end connections in a GMPLS transport network where traffic is handled by means of Label Switched Paths-connections established using the label switching principle. The problem is important for the networks where labels are a scarce/expensive resource, like in optical networks.

An operational calculus for matrix-exponential disributions, with applicaions to a Brownian (q,Q) inventory model

distribution G on [math not displayed] is called matrix-exponential if the density has the form αeTz s where α is a row vector, T a square matrix and s a column vector. Equivalently, the Laplace transform is rational. For such distributions, we develop an operator calculus, where the key step is manipulation of analytic functions f(z) extended to matrix arguments. The technique is illustrated via

Non-germ-line encoded residues are critical for effective antibody recognition of a poorly immunogenic neutralization epitope on glycoprotein B of human cytomegalovirus.

The capability of the antibody (Ab) repertoire to mount a response to appropriate epitopes on infectious agents will strongly affect the ability of the immune system to provide protection against disease. Certain epitopes may be poor inducers of immunity but are nevertheless able to promote biologically important protection when recognized by the immune repertoire. We have investigated the recogni

Development of an automated method for display of ischemic myocardium from simulated electrocardiograms.

BACKGROUND: Knowledge of the size and location of ischemic myocardium during acute coronary occlusion could provide decision support before reperfusion therapy. Electrocardiogram (ECG) scores based on the number of leads and the sum of ST-segment elevation have been unreliable in quantifying ischemia. We aimed to develop a new method to graphically display ischemic myocardium from simulated ECGs (

Attenuation of tumor growth by formation of antiproliferative glycosaminoglycans correlates with low acetylation of histone H3.

Glycosaminoglycan (GAG) chains anchored to core proteins form proteoglycans, widely distributed cell-surface macromolecules with multiple functions, such as regulation of growth factor and cytokine signaling, cell-cell interactions, and uptake of biomolecules. The biosynthesis of GAG can be manipulated by xylosides attached to various hydrophobic groups, and we have earlier reported that a naphtho

Lund High-power Laser Facility - Systems and 1st Results

A high-power laser facility has been established at the Lund Institute of Technology, Sweden, available to national groups and their international collaboration partners. The laboratory incorporates three major 10 Hz laser systems, that can be operated individually or synchronized in combined use. Each system represents extreme optical powers in a certain sense. The main system is a terawatt laser

St. Birgitta, an Architect of Spiritual Reform

The shape and features of a typical abbey church of the Birgittine Order are studied, based on the stipulations laid down by St. Birgitta of Sweden herself. The architecture is interpreted as paradigmatic of the kind of spiritual reform that St. Birgitta aimed at.