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Perspectives that lay persons with and without health problems show toward coronary heart disease: An integrated biopsychosocial approach.

Objective: We studied what patients with acute coronary heart disease (CHD) considered the three most stressful factors experienced during the month before testing and what they attributed their heart disease to. Methods: We studied the occurrence and severity of physiologic, psychologic, and psychosocial stressors in 117 patients with acute CHD and 117 referents, not diagnosed with CHD, matched b

Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry

Objective: To elucidate variations in tissue ultrastructure and incidence of pathology between fibromodulin (FM)-null mice and wild-type (WT) animals. Design: FM-null and WT siblings from different age groups were compared. Serial sections were made through paraffin-embedded whole knees and investigated histologically. Additionally, medial femoral condyle peaks from sibling pairs were investigated

Successes and Failures of Kadanoff-Baym Dynamics in Hubbard Nanoclusters

We study the nonequilibrium dynamics of small, strongly correlated clusters, described by a Hubbard Hamiltonian, by propagating in time the Kadanoff-Baym equations within the Hartree-Fock, second Born, GW, and T-matrix approximations. We compare the results to exact numerical solutions. We find that the time-dependent T matrix is overall superior to the other approximations, and is in good agreeme

Particle Emission from High-spin States

The present status of prompt particle emission from high-spin states in the mass A~60 region is shortly summarized. The focus lies on recent results from a GAMMASPHERE experiment, which aimed at the combined in-beam high-resolution spectroscopy of light charged particles and γ rays. More detailed studies of known cases as well as the identification of new cases of discrete prompt proton and α-part

Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro

Osteocalcin detected from serum samples is considered a specific marker of osteoblast activity and bone formation rate. However, osteocalcin embedded in bone matrix must also be released during bone resorption. To understand the contribution of each type of bone cell in circulating osteocalcin levels, we used immunoassays detecting different molecular forms of osteocalcin to monitor bone resorptio

On the mechanism of electrophoretic migration of DNA in pluronic gels

Capillary electrophoresis of nucleic acids has recently employed gels of self-assembled uncharged triblock copolymers as sieving media. Pluronic F127 contains poly(ethylene oxide) (EO) and poly(propylene oxide) (PO) with the block structure (EO)(106)(PO)(70)(EO)(106). Aqueous solutions of 30% w/w of this polymer are liquids at low temperatures but above 11 degreesC the polymers assemble to micelle

Optimization with genetic algorithms of a gas turbine cycle with H-2-separating membrane reactor for CO2 capture

A gas turbine power process with CO2 capture through precombustion decarbonization, which employs a H-2-separating membrane reactor is presented. Optimization with the process thermal efficiency as objective function is made through the use of genetic algorithms. The use of genetic algorithms enabled a division of the optimization parameters into two groups; one group where the values are at their

Chelate and bridge diphosphine isomerization: triosmium and triruthenium clusters containing 1,1-bis(diphenylphosphino)ferrocene (dppf)

The coordination mode of dppf {dppf = 1,1'-bis(diphenylphosphino)ferrocene} at triosmium and triruthenium carbonyl clusters has been studied. Heating [Os3(CO)12] with dppf in the presence of Me3NO in benzene at 60 C furnishes three triosmium compounds, [Os3(CO)11(1-dppf)] (1), [Os3(CO)10(2-dppf)] (2), and [Os3(CO)10(-dppf)] (3) in 10, 20, and 30% yields, respectively. Reaction of the labile cluste

Oral mucosal microvascular network abnormalities in de novo mutation achondroplasia

Approximately 90% of achondroplasia (ACH) cases are the result of a de novo mutation, with no phenotypical markers for the unaffected ACH parents being known to date. Here, the hypothesis of the presence of an oral mucosal microvascular abnormality in ACH children and unaffected ACH parents was tested. Two-dimensional vascular network geometry was analyzed in 15 children with sporadic ACH, 30 unaf

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia

Although it has been suggested that mutations of the FLT3, NRAS, KRAS, and PTPN11 genes are particularly frequent in high hyperdiploid (>50 chromosomes) pediatric acute lymphoblastic leukemias (ALLs), this has as yet not been confirmed in a large patient cohort. Furthermore, it is unknown whether mutations of these genes coexist in hyperdiploid cases. We performed mutation analyses of FLT3, NRAS,

The cost of feedback microwave thermotherapy compared with transurethral resection of the prostate for treating benign prostatic hyperplasia.

OBJECTIVE: To compare the efficacy of a new microwave thermotherapy for treating benign prostatic hyperplasia (BPH), the ProstaLund Feedback Treatment (PLFT, ProstaLund Operations AB, Lund, Sweden) and transurethral resection of the prostate (TURP) in a clinical trial to their effectiveness in clinical practice over 1 year, to estimate their cost over 1 year, and to evaluate the cost of re-interve

Measurement of direct photon production in p+p collisions at root s=200 GeV

Cross sections for midrapidity production of direct photons in p+p collisions at the Relativistic Heavy Ion Collider (RHIC) are reported for transverse momenta of 3 < p(T)< 16 GeV/c. Next-to-leading order perturbative QCD (pQCD) describes the data well for p(T)> 5 GeV/c, where the uncertainties of the measurement and theory are comparable. We also report on the effect of requiring the photons to b

N-CAM Exhibits a Regulatory Function in Pathological Angiogenesis in Oxygen Induced Retinopathy

Background: Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Muller cells and astrocytes, which are in close c

An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA

Aims To compare the British Isles Lupus Assessment Group (BILAG) 2004, the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) and physician's global assessment (PGA) in assessing flares of disease activity in patients with systemic lupus erythematosus (SLE). Methods Sixteen patients with active SLE were assessed by a panel of 16 rheumatologists. The order in

Psychological aspects of patients with psoriasis: Biological and clinical studies

Popular Abstract in Swedish Psoriasis är en av våra vanligaste folksjukdomar, som drabbar 2-3 % av den vuxna befolkningen. Man vet i dag att många patienter med psoriasis lider av psykisk ohälsa och sänkt livskvalitet. Sjukdomen i sig innebär ofta en stor psykologisk påfrestning för patienten, men stress och psykisk ohälsa också kan vara en viktig orsak till insjuknande och återfall av psoriasis. Psychological distress is well known to be associated with psoriasis, both as a disease consequence, and as a causative factor for onset and exacerbations. Psychoneuroimmunological mechanisms have been suggested to be involved in the pathogenesis of psoriasis and have often been shown to be related to psychological distress and pruritus in psoriasis. The general aim of this thesis was to investig

Efter doktorsexamen - en alumnstudie

Forskarutbildningen har ett dubbelt syfte, att utbilda framtidens universitetslärare och forskare samt att utgöra rekryteringsbas för andra delar av offentlig sektor och privat sektor. Resultaten av denna alumnundersökning visar att Lunds universitet väl svarar upp mot detta dubbla rekryteringssyfte. Av doktoranderna i undersökningen, riktad till examinerade år 2004, hade nästan nästan samtliga (9

Low RBM3 Protein Expression Correlates with Clinical Stage, Prognostic Classification and Increased Risk of Treatment Failure in Testicular Non-Seminomatous Germ Cell Cancer.

Expression of the RNA-binding motif protein 3 (RBM3) has been shown to correlate with favourable clinicopathological parameters and prognosis in several cancer diseases. The aim of this study was to examine the expression and prognostic ability of RBM3 in patients with testicular non-seminomatous germ cell tumours (NSGCT).