Common variable immune deficiency (CVID) is a heterogeneous disorder characterized by recurrent infections, low levels of serum immunoglobulins, and impaired vaccine responses. Autoimmune manifestations are common, but B cell central and peripheral selection mechanisms in CVID are incompletely understood. Here, we find that receptor editing, a measure of central tolerance, is increased in transiti

B cells generate antibodies that are essential for immune protection, but their subgroups are poorly defined. Here, we perform undirected deep profiling of B cells in matched human lymphoid tissues from deceased transplant organ donors and blood. In addition to identifying unanticipated features of tissue-based B cell differentiation, we resolve two subsets of marginal zone B (MZB) cells differing

Development of the Drosophila visceral muscle depends on Anaplastic Lymphoma Kinase (Alk) receptor tyrosine kinase (RTK) signaling, which specifies founder cells (FCs) in the circular visceral mesoderm (VM). Although Alk activation by its ligand Jelly Belly (Jeb) is well characterized, few target molecules have been identified. Here, we used targeted DamID (TaDa) to identify Alk targets in embryos

This study examines the long-term effect of Christian missionary exposure on HIV infection and related sexual behaviour in Zambia. I use distance to a historical missionary church and health facility as proxies for missionary exposure. I constructed a geocoded data set combining information on the historical locations of churches and missionary health centres with contemporary individual-level dat

Measurements of Higgs boson production cross-sections are carried out in the diphoton decay channel using 139 fb−1 of pp collision data at s = 13 TeV collected by the ATLAS experiment at the LHC. The analysis is based on the definition of 101 distinct signal regions using machine-learning techniques. The inclusive Higgs boson signal strength in the diphoton channel is measured to be 1.04−0.09+0.10

Measurements of differential cross sections are presented for inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13 TeV provided by the LHC and using 139 fb −1 of data recorded by the ATLAS experiment. The cross sections are measured as functions of the photon transverse energy in different regions of photon pseudorapidity. The photons are required to be isolated b

The historic urban area of Lisbon emerged during the Middle Ages and was the origin of the development of a rather small neighbourhood, Mouraria. Not only did it count as the centre of the capital, but because of Lisbon being the metropolis of the Portuguese empire, Mouraria is now home to a diverse group of people, whose culture influences its special characteristics to this day. Its medieval str

Occupational therapists support and enable people to partake in occupations or activities that are important to them; that they need/want/are expected to do. Occupational therapists are increasingly involved in services addressing the impact that social inequalities can have on peoples’ wellbeing. One way in which occupational therapy students in NUI Galway learn relevant skills is through service

The interaction between nitrogen monoxide (NO) and organic peroxy radicals (RO2) greatly impacts the formation of highly oxygenated organic molecules (HOM), the key precursors of secondary organic aerosols. It has been thought that HOM production can be significantly suppressed by NO even at low concentrations. Here, we perform dedicated experiments focusing on HOM formation from monoterpenes at l

Vi har mycket att lära från länder som Kanada, där civilsamhället spelar en betydligt mer framträdande roll i integrationsarbetet. Det skriver professor emeritus Benny Carlson samt Oskar Adenfelt och Johanna Hemberg, Fores.

Sub-THz frequencies are tomorrow's hot research area in mobile communication. However, in this range of frequencies the systems are complex, and it is hard to explore various system architectures and correlate the system-level solutions with circuit-level performances and requirements. This paper presents a scalable testbench in MATLAB/Simulink for sub-THz hybrid beamforming receivers. The testben

In the realm of cloud computing, the prevalence of intra-phase congestion due to concurrent periodic requests from a multitude of clients frequently results in heightened resource consumption, elongated queuing times, and prolonged response durations. To tackle these challenges, this paper presents a groundbreaking 'Adaptive Out-of-Phase Scheduling' technique, utilizing a server-side PID controlle

In this paper, we develop a novel method for approximate continuous-discrete Bayesian filtering. The projection filtering framework is exploited to develop accurate approximations of posterior distributions within parametric classes of probability distributions. This is done by formulating an ordinary differential equation for the posterior distribution that has the prior as initial value and hits

In a special run of the LHC with β⋆= 2.5 km, proton–proton elastic-scattering events were recorded at s=13 TeV with an integrated luminosity of 340μb-1 using the ALFA subdetector of ATLAS in 2016. The elastic cross section was measured differentially in the Mandelstam t variable in the range from - t= 2.5 · 10 - 4 GeV 2 to - t= 0.46 GeV 2 using 6.9 million elastic-scattering candidates. This paper

Background: Knowledge about ageing from the perspective of people with intellectual disability is extremely scarce, which means a lack of evidence-based interventions for healthy ageing adjusted to their needs. Aim: To investigate how people with intellectual disability experience ageing, prior to an educational intervention. Methods: Twenty-six persons with mild intellectual disability, age 42-7