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Different Problem, Same Solution: Contract-Specialization in Venture Capital

Real-world financial contracts vary greatly in the combinations of cash flow contingency terms and control rights used. Extant theoretical work explains such variation by arguing that each investor finely tailors contracts to mitigate investment-specific incentive problems. We provide overwhelming evidence from 4,561 venture capital (VC) contracts that this tailoring is overstated: even though the

A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation

Background Testicular dysgenesis syndrome (TDS) is a common disease that links testicular germ cell cancer, cryptorchidism and some cases of hypospadias and male infertility with impaired development of the testis. The incidence of these disorders has increased over the last few decades, and testicular cancer now affects 1% of the Danish and Norwegian male population. Methods To identify genetic v

Data processing methods and quality control strategies for label-free LC-MS protein quantification.

Protein quantification using different LC-MS techniques is becoming a standard practice. However, with a multitude of experimental setups to choose from, as well as a wide array of software solutions for subsequent data processing, it is non-trivial to select the most appropriate workflow for a given biological question. In this review, we highlight different issues that need to be addressed by so

Online Piracy, Anonymity and Social Change – Deviance Through Innovation

This article analyses current trends in the use of anonymity services among younger Swedes (15-25) and focuses on individuals engaging in illegal file sharing in order to better understand the rationale behind both file sharing as well as online anonymity, especially in relation to enforcement of copyright. By comparing the findings of a survey conducted on three different occasions (early 2009, l

Long-term prognosis of cerebral vein and sinus thrombosis

In recent reports, cerebral vein and sinus thrombosis has had a better long-term prognosis than previously thought. However, there may be long-term problems that have not attracted enough attention. The aim of this chapter is to examine the literature for studies reporting long-term prognosis and outcome after cerebral vein and sinus thrombosis. The long-term prognosis after cerebral vein and sinu

A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors.

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

High resolution study of the inner-shell 3p-3d and 3p-5s resonance regions in calcium atoms

The 3p(5)4s(2)3d P-1(1) and 3p(5)(P-2(3/2))4s(2)5s (2)[3/2](1) resonance regions of Ca atoms have been studied experimentally with the aid of synchrotron radiation excited electron spectroscopy. The strong configuration interaction of the 3p(5)4s(2)3d, 3p(5)4s(2)5s and several other nearly degenerate configurations leads to complex structures observed in the photoelectron yield spectrum. Multiconf

Identifying and characterizing the most significant beta-glucosidase of the novel species Aspergillus saccharolyticus

The newly discovered fungal species Aspergillus saccharolyticus was found to produce a culture broth rich in beta-glucosidase activity. In this present work, the main beta-glucosidase of A. saccharolyticus responsible for the efficient hydrolytic activity was identified, isolated, and characterized. Ion exchange chromatography was used to fractionate the culture broth, yielding fractions with high

An improved decision rule for emergency replenishments

This paper provides a new decision rule for emergency replenishments in an inventory system. The decision rule is a generalization of a previous decision rule suggested and evaluated in Axsater (2003, 2007). An improvement step is added to this rule and this often means considerably better performance. The decisions are based on complete information about the system state. An advantage with our de

High-precision dating of the Kalkarindji large igneous province, Australia, and synchrony with the Early-Middle Cambrian (Stage 4-5) extinction

The voluminous Kalkarindji flood basalts erupted in Australia during the Cambrian and covered >2 x 10(6) km(2). New U-Pb and Ar-40/Ar-39 age data from intrusive rocks and lava flows yielded statistically indistinguishable ages at ca. 511 Ma, suggesting a relatively brief emplacement for this province. A zircon age of 510.7 +/- 0.6 Ma shows that this province is temporally indistinguishable at the

SUSPENSION CRITERIA FOR IMAGE MONITORS AND VIEWING BOXES.

Image monitors and viewing boxes have a crucial role in the diagnostic process. Modern radiology uses different modalities to produce digital images which are to be viewed in different parts of the radiology department and throughout the hospital, sometimes simultaneously, via the Picture Archiving and Communications System (PACS). Therefore, the quality of the image monitors is of great importanc

Comparison between Weibull and Gamma distributions to derive synthetic unit hydrograph using Horton order ratios

The two-parameter Weibull distribution (2PWD), similar to an instantaneous unit hydrograph (IUH), is parameterized in terms of Horton catchment ratios on the basis of a geomorphologic model of catchment response. For this the shape and scale parameters of the Weibull distribution are expressed analytically in terms of Horton's catchment ratios. The two parameters of the IUH derived using Nash's mo

Brains, genes and environment of suicide attempters

Identification of symptoms or biological abnormalities that predispose to suicide or identifies specific vulnerabilities, may one day improve allocation of resources or help tailor treatment to the patient. Paper I: We compared the predictive value of symptom-oriented questions against direct questions about suicidality in assessing risk for suicide attempts. The self-rated Suicide Assessment Sca

Biomass pyrolysis in a heated-grid reactor: Visualization of carbon monoxide and formaldehyde using Laser-Induced Fluorescence

The development of improved biomass pyrolysis models is vital for more accurate modelling and design of biomass conversion equipment. Such improved models must be based on reliable experimental data: biomass should be pyrolyzed at high heating rates and the reaction products should be measured using an on-line, non-intrusive method. Therefore, a heated grid reactor with heating rate of 300-600 K/s

A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit.

Preeclampsia is one of the most serious pregnancy-related diseases and clinically manifests as hypertension and proteinuria after 20 gestational weeks. The worldwide prevalence is 3-8% of pregnancies, making it the most common cause of maternal and fetal morbidity and mortality. Preeclampsia lacks an effective therapy, and the only "cure" is delivery. We have previously shown that increased synthe

A model framework for tree leaf colouring in Europe

Ecosystem productivity is influenced by the start and end of the growing season, and ecosystem models that simulate productivity need reliable representations of the phenology. For the seasonal development, autumn events are less understood than spring events, with comparatively fewer modelling attempts have been made for leaf senescence than for budburst. The few existing models for autumn phenol