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OBJECTIVE: To investigate the relationship between enlarged perivascular spaces (EPVS) and measures of Alzheimer disease (AD), small vessel disease (SVD), cognition, vascular risk factors, and neuroinflammation, we tested associations between EPVS and different relevant neuroimaging, biochemical, and cognitive variables in 778 study participants. METHODS: Four hundred ninety-nine cognitively unimp
Obesity is a growing health problem and challenge to the health care systems in the western world. Available treatment is limited to lifestyle modifications, cognitive therapy, drugs and bariatric surgery. On one hand, lifestyle changes and pharmacological treatment have very limited long-term effects on obesity. On the other hand, bariatric surgery is effective to maintain long-term weigh reducti
Incubating birds trade off self-maintenance for keeping eggs warm. This causes lower incubation temperature in more challenging conditions, with consequences for a range of offspring traits. It is not yet clear how low developmental temperature affects cold tolerance early in life. This is ecologically important because before full thermoregulatory capacity is attained, precocial chicks must switc
Permafrost extends 40% of the Qinghai-Tibet Plateau (QTP), a region which contains the headwaters of numerous major rivers in Asia. As an aquiclude, permafrost substantially controls surface runoff and its hydraulic connection with groundwater. The freeze–thaw cycle in the active layer significantly impacts soil water movement direction, velocity, storage capacity, and hydraulic conductivity. Unde
The high-resolution Sentinel-2 data potentially enable the estimation of gross primary productivity (GPP) at finer spatial resolution by better capturing the spatial variation in a heterogeneous landscapes. This study investigates the potential of 10 m resolution reflectance from the Sentinel-2 Multispectral Instrument to improve the accuracy of GPP estimation across Nordic vegetation types, compa
Mediterranean diet protects from both cardiovascular disease (CVD) and cancer. In the 1960s, Ancel Keys defined the concept of Mediterranean diet in the South Italian region of Cilento and proposed it as a key factor for healthy ageing in the region. The aim of the current study was to compare the prevalence of CVD and cancer between a middle-aged population from Cilento and those of a Northern Eu
Hot electron relaxation and transport in nanostructures involve a multitude of ultrafast processes whose interplay and relative importance are still not fully understood, but which are relevant for future applications in areas such as photocatalysis and optoelectronics. To unravel these processes, their dynamics in both time and space must be studied with high spatiotemporal resolution in structur
Information about forest background reflectance is needed for accurate biophysical parameter retrieval from forest canopies (overstory) with remote sensing. Separating under- and overstory signals would enable more accurate modeling of forest carbon and energy fluxes. We retrieved values of the normalized difference vegetation index (NDVI) of the forest understory with the multi-angular Moderate R
Background: Pancreatic ductal adenocarcinoma has the lowest survival rate among all major cancers and is the third leading cause of cancer-related mortality. The stagnant survival statistics and dismal response rates to current therapeutics highlight the need for more efficient preclinical models. Patient-derived organoids (PDOs) offer new possibilities as powerful preclinical models able to accou
To avoid harm to the public and the environment, lost ionizing radiation sources must be found and brought back under the regulatory control as soon as possible. Usually, mobile gamma spectrometry systems are used in such search missions. It is possible to estimate the position and activity of point gamma sources by performing Bayesian inference on the measurement data. The aim of this study was t
This paper describes an original numerical prediction technique developed for the analysis of coupled vibro-acoustic problems in fluid waveguides. Specifically it is is a wave-based method. Unlike the conventional element-based methods, this technique uses wave functions that satisfy the governing equations to describe the dynamic variables exactly. One advantage is that fine domain discretization
Since the dawn of its existence, and at times thanks to ambitious interventions, Venice and its lagoon have needed to be constantly protected from the various ways in which water has reclaimed its existence. This article asserts that the ways in which Venice approached the watery world imply a tendency to relate to the natural environment as if it was something humans ought to separate themselves
We present a new analog-to-digital converter (ADC)-based architecture of a phase-tracking receiver (PT-RX) optimized for ultra-low-power (ULP) and ultra-low-voltage (ULV) operations for the Internet of Things (IoT). The RX employs a type-II loop configuration that offers improved stability compared with the previous type-I PT-RX solutions. In addition, the type-II loop is also very tolerant of lon
Objectives: To assess whether vessel morphology depicted by three-dimensional (3D) power Doppler ultrasound improves discrimination between benignity and malignancy if used as a second-stage test in adnexal masses that are difficult to classify. Methods: This was a prospective observational international multicenter diagnostic accuracy study. Consecutive patients with an adnexal mass underwent sta
The US has experienced a substantial decline in social trust in recent decades. Surprisingly few studies analyze whether individual-level explanations can account for this decrease. We use three-wave panel data from the General Social Survey (2006–2014) to study the effects of four possible individual-level sources of changes in social trust: job loss, social ties, income, and confidence in politi
OBJECTIVE: We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose sensiti
Climate change is increasingly acknowledged as a threat to states and societies, and several international organizations are now seeking to respond to climate-related security risks. The EU’s comprehensive approach to security suggests that the Union is particularly well-suited to respond to such risks, but the EU has not yet developed a coherent policy. This article addresses the gap between disc
In the report we analyse the concept of capability and compare it to relatedconcepts such as resilience. With starting point in a sociotechnical systemperspective as well as existing research on capability and vulnerability wedevelop an analytical framework that could be used to study the capability indifferent energy systems. We suggest that capability could be seen as composedof five “building b
