Konsten att ”baka” fram en hjärnsjukdomsmodell Sjukdomar som påverkar hjärnan blir allt vanligare allt eftersom vi åldras och medellivslängden i världen ökar. Senilitet, som en gång i tiden ansågs vara en nästan oundviklig del av att bli gammal. Idag förstår vi att det har att göra med neurodegenerativa sjukdomar, som kan pågå i många år med stegvisa humörförändringar och små ändringar i beteendNeuronopathic Gaucher’s Disease is an early-onset neurological disorder with progressive dysfunction and degeneration of neuronal cells, caused by dysfunctions in the endosomal-autophagic-lysosomal pathway. A lysosomal enzyme deficiency results in accumulation of substrate and subsequent impairment of the lysosomes. While the cause is known, the disease mechanisms driving the neurodegeneration are

Many evidence supports the notion that protein aggregation in the brain leads to neurodegenerative diseases, characterized by progressive degeneration of neuron structure and function in the brain. Protein aggregation causes a variety of diseases such Alzheimer’s disease (AD) and Parkinson’s disease (PD). Generation of extracellular amyloid-beta (Ab) plaques and aggregation of α-synuclein (α-syn),Several studies suggest that protein aggregation in the brain leads to neurodegenera-tive diseases. Two examples of this are seen in the neuropathological hallmarks of Parkinson’s disease (PD) and Alzheimer’s disease (AD) in the form of a-synuclein (a-syn) and amyloid-beta (Ab) plaques, respectively. However, an overlap of these pa-thologies has been observed in more than 50% of AD cases. This res

Evolvering av textklassificerare med hjälp av genetisk programmering Genetisk programmering (GP) är ett område inom AI som är inspirerat av den biologiska evolutionen. I detta arbete använder vi genetisk programmering för att evolvera fram textklassificerare. Denna metod ger många fördelar som dagens teknik saknar. Textklassificering går ut på att kategorisera textdata efter fördefinierade klassText classification is one of the main tasks within the field of natural language processing, which has been growing significantly during the last decade with applications in different industries. Despite different approaches to text classification showing good results, such as Machine Learning and Deep Learning, their shortcomings give substance to the need for further research on other approache

In today’s society fast fashion has taken over the consumers and prices on clothes are so low that the clothes have lost their value due to their disposability. People are consuming more than they need and also throwing away clothes that they no longer need but are still fully functional. In short, we need to change our consumer habits. This paper will be exploring the sharing economy focusing on

Denna uppsats syftar till att undersöka vilka hinder och begränsningar livförsäkringsföretag möter vid implementeringen av maskininlärning i deras beslutsprocesser avseende livförsäkringar, inom allt från teknik till juridik. Uppsatsen nämner även potential och möjligheter som ges av den nya tekniken. Studien genomförs genom att först beskriva försäkringsmarknaden, för att sedan gå djupare på den

Cancer patients often show varying response when given the same treatment for the same cancer type. This is especially true for cancer types with high molecular heterogeneity such as B-cell lymphomas which is a haematological cancer subtype. Because of this varying treatment response, research is moving towards enabling personalized medicine where a treatment is selected for each individual patien

The goal of this master thesis has been to implement adaptive PI-control of two air flow heaters in an air sterilization module. This is done by modeling the module and using the information from the model to estimate the dynamics of the heaters. The idea of this thesis is to implement adaptive control with as simple control structures and tuning algorithms as possible, to keep it as generalized

During recent years, advancements in mobile technology have enabled the development of quadcopters and unmanned aerial vehicles (UAV) to the point where their size and maneuverability enable indoor flight. In such GPS-denied environments, accurate positioning is a challenge which poses difficulties during flight, navigation and landing. Such positioning systems exist, but are often expensive or re

This thesis studies a network game of heterogeneous and asymmetric public goods. Players allocate their wealth between private and public goods, benefiting from the public goods provisioned by their out-neighbors on the network graph. Utilities are given by a Cobb-Douglas function to capture substitutability and decreasing marginal returns. I prove that the game is well-behaved under a condition r

Production and patient safety requirements are high in pharmaceutical industries where standards are set accordingly and controlled by e.g. the U.S. Food and Drug Administration (FDA). It is crucial that these standards are met without compromising the fact that production must run as effectively as possible, i.e. achieve Overall Equipment Efficiency (OEE), for the pharmaceutical companies to deli

The present study concerns the implementation of a voluntary job rotation program for individual and organizational development. In order to increase participation in job rotation programs, it is crucial to understand the phenomenon of non-participation. Accordingly, the present study aims to (a) identify reasons for non-participation from an employee perspective and (b) uncover possible hindrance

Uppsatsen ämnar att, på ett djupare plan, synliggöra vad som kan upplevas ingå i polisens arbetsuppgifter utöver det praktiska arbetet. Hur upplever poliser i yttre tjänst relationen mellan polisrollens krav och personliga känslor? Hur hanterar poliser i yttre tjänst egna emotioner i tjänstgöring utifrån yrkesrollens krav? Hur påverkas poliserna av relationen mellan yrkesrollens krav och personlig

In an effort to curb climate change, the electric power system in many countries is transitioning from fossil fuels to more renewable power sources such as wind. At the same time, other countries are decommissioning their old nuclear power, and replacing it with wind power. When replacing synchronous machines with wind power the inertia in the system is decreased. If nothing is done about this the

Electrolytic capacitor components degrade when exposed to thermal stress which can cause failures in electrical devices. Several recent works have studied the lifetime of these components by using accelerated life testing. This work, however, takes a new approach by utilising vast amounts of temperature data and regression techniques. Axis Communications collects large amounts of non-personalised

Mikrobiella allierade för en hållbar matproduktion Människans matproduktion har problem. Samtidigt som det pågår stora påtryckningar från samhället att övergå till mer hållbara jordbruksformer måste vi hela tiden producera mat till fler människor. Hur kan vi skala upp matproduktionen samtidigt som vi måste värna om den biologiska mångfalden och möta klimatmålen? Istället för kemiska bekämpningsmeNew approaches in agriculture utilizing plant-growth promoting microorganisms have the potential to decrease our reliance on artificial fertilizers and pesticides, which is an evergrowing societal concern. Fungi of the genus Trichoderma are abundant in soils all over the world and can positively affect plant stress tolerance and yield. However, this growthpromoting effect is dependent on the plant

Influenza is the causative agent of the flu. Symptoms usually include fever, coughing, and general malaise. Besides the general societal burden, influenza can also threaten global health when mixing its genome with influenza viruses in birds or pigs, as exemplified by the 1918 Spanish flu pandemic. The virus uses its proteins haemagglutinin (HA) and neuraminidase (NA) to get in or away from host c

High Migratory and Cytotoxic Capability of CD56bright NK Cells in a Blood-Brain-Barrier in Vitro Model The blood brain barrier (BBB) is a tight structure in the Central Nervous System (CNS) that restricts the entry of immune cells. This restriction is regulated by different components such as endothelial cells, tight junction proteins and other cells such as pericytes, astrocytes and neurons. Nat

Development of a successful prophylactic or therapeutic treatment for active Tuberculosis (TB) has been hampered by the bacilli’s ability to evade, tolerate, subvert host immunity and persist in a hypoxic intracellular niche. Upon infection with M. tuberculosis (Mtb), there is an increased demand for metabolites by cells to respond to the robust immune activation, which is met with a shift of meta