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Spatially Coupled Hybrid Concatenated Codes

The main purpose of this paper is to make the study of spatially coupled turbo-like codes (SC-TCs) more complete by investigating the impact of spatial coupling on the thresholds of hybrid concatenated codes (HCCs). In our previous studies, we introduced some classes of SC-TCs and considered their density evolution (DE) analysis. The obtained results indicated that for a fixed coupling memory, bra

Automatic Gleason grading of H&E stained microscopic prostate images using deep convolutional neural networks

Prostate cancer is the most diagnosed cancer in men. The diagnosis is confirmed by pathologists based on ocular inspection of prostate biopsies in order to classify them according to Gleason score. The main goal of this paper is to automate the classification using convolutional neural networks (CNNs). The introduction of CNNs has broadened the field of pattern recognition. It replaces the classic

Characterisation of human AV-nodal properties using a network model

Characterisation of the AV-node is an important step in determining the optimal form of treatment for supraventricular tachycardias. To integrate and analyse patient-specific measurements, mathematical modelling has emerged as a valuable tool. Here we present a model of the human AV-node, consisting of a series of interacting nodes, each with separate dynamics in refractory time and conduction del

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated.

Statistical modeling of atrioventricular nodal function during atrial fibrillation : An update

This paper introduces a number of advancements of our recently proposed model of atrioventricular (AV) node function during atrial fibrillation (AF). The model is defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two AV nodal pathways, the refractory periods of these pathways, and their prolongation. In the updated mo

Paris and Stockholm in the novels Illusions Perdues de Balzac and The Red Room by August Strindberg

ACLA 2017, Seminar with Richard Hibbitt: ”Other Capitals of the Nineteenth Century”Annika Mörte Alling, Lund UniversityParis and Stockholm in the novels Illusions Perdues de Balzac and The Red Room by August StrindbergI propose to study the conceptions of Paris and Stockholm in the two realist novels Illusions Perdues by Honoré de Balzac (1837-1843) and The Red Room (1879) by August Strindberg, pe

Family history of cardiometabolic diseases and its association with arterial stiffness in the Malmö Diet Cancer cohort

OBJECTIVE:: Arterial stiffening increases with age and is associated with increased cardiovascular risk. Several risk factors have been shown to predict the development of arterial stiffening; however, a positive family history (FH+) of cardiometabolic disease (CMD) and hypertension has not been extensively studied. We hypothesize that FH+ of CMD plays a significant role in the development of arte

Trends in Otitis Media Incidence After Conjugate Pneumococcal Vaccination; A National Observational Study

BACKGROUND:: Pneumococcal conjugate vaccine (PCV) was introduced in 2000. The first 7-valent vaccine was followed by a 13-valent vaccine (PCV13) with the same conjugate, and a 10-valent vaccine (PCV10), conjugated to protein D from H. influenzae. The vaccines offer some protection against pneumococcal acute otitis media (AOM), and, with PCV10, possibly also some protection against H. influenzae AO

Rules of Recognition : Explaining Diplomatic Representation in the Long Nineteenth Century

The aim of this paper is to explore the establishment of diplomatic representation as a measure of de facto recognition by other state units, and to explain its causes in the “long 19th century” (1817-1914). The premise of the paper is that, at least before the advent of broad-ranging legitimizing international organizations such as the League of Nations or the UN in the 20th century, sending a di

Reduced frizzled receptor 4 expression prevents WNT/b-catenin-driven alveolar lung repair in chronic obstructive pulmonary disease

Rationale: Chronic obstructive pulmonary disease (COPD), in particular emphysema, is characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and INT-1 (WNT)/b-catenin signaling is reduced in COPD; however, the mechanisms thereof, specifically the role of the frizzled (FZD) family of WNT receptors, remain unexplored. Objectives: To identify and functionally charact

Comparative Decellularization and Recellularization of Wild-Type and Alpha 1,3 Galactosyltransferase Knockout Pig Lungs : A Model for Ex Vivo Xenogeneic Lung Bioengineering and Transplantation

Background: A novel potential approach for lung transplantation could be to utilize xenogeneic decellularized pig lung scaffolds that are recellularized with human lung cells. However, pig tissues express several immunogenic proteins, notably galactosylated cell surface glycoproteins resulting from alpha 1,3 galactosyltransferase (α-gal) activity, that could conceivably prevent effective use. Use

An official American Thoracic Society workshop report : Stem cells and cell therapies in lung biology and diseases

The University of Vermont College of Medicine and the Vermont Lung Center, in collaboration with the NHLBI, Alpha-1 Foundation, American Thoracic Society, European Respiratory Society, International Society for Cell Therapy, and the Pulmonary Fibrosis Foundation, convened a workshop, "Stem Cells and Cell Therapies in Lung Biology and Lung Diseases, " held July 29 to August 1, 2013 at the Universit

Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice

An increasing number of studies demonstrate that administration of either conditioned media (CM) or extracellular vesicles (EVs) released by mesenchymal stromal cells (MSCs) derived from bone marrow and other sources are as effective as the MSCs themselves in mitigating inflammation and injury. The goal of the current study was to determine whether xenogeneic administration of CM or EVs from human

Comparative decellularization and recellularization of normal versus emphysematous human lungs

Acellular whole human lung scaffolds represent a unique opportunity for ex vivo tissue engineering. However, it remains unclear whether lungs from individuals with chronic lung diseases such as chronic obstructive pulmonary disease (COPD) can be appropriately decellularized and recellularized. To assess this, cadaveric human lungs from normal (non-smoking) patients and from patients with COPD (smo