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Introduction: The role of chemotherapy for patients with dedifferentiated chondrosarcoma (DDCS) is still under discussion. Here, we present the outcome in patients with DDCS treated with intensive chemotherapy from the EUROpean Bone Over 40 Sarcoma Study. Materials and methods: The chemotherapy regimen included doxorubicin, ifosfamide and cisplatin. Postoperative methotrexate was added in case of

This paper looks into the system of student informants (xuesheng xinxiyuan), which is, to systematically recruit and more generally, to mobilise or encourage the students to watch and inform on their professors on university campuses in China. After Xi Jinping assumed power in late 2012, along with the Chinese Communist Party’s intensifying control of university space, mounting reports show that p

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD

Along with China’s long-delayed response to the COVID-19 outbreak is its nationwide activation of the ‘gridded management’ system. Relying largely on the mass recruitment of the war-time rhetoric and ideology in mobilizing the people to watch and tell on each other, this ‘gridded management’ system is officially highlighted as playing a key role in China’s combat against COVID-19. Through examinin

The cutback was widely used in advanced gas turbines to protect the trailing edge. The land was a main structure in the cutback region. Therefore, the present study describes a numerical investigation on the film cooling performance in the cutback region with various land shapes (straight- expanding land, arch- expanding land, contracting- expanding land and campaniform land) and blowing ratios (0

Herwig 7 is a general-purpose Monte Carlo generator of particle collisions comprising both hard perturbative as well as soft phenomenological physics. Herwig is therefore capable to describe the entire final state of hadronized particles in a collision event. A spacetime topology of a parton system entering hadronization is fully described and tested for the first time. A combination of informatio

The correlation function measured in ultrarelativistic nuclear collisions is strongly non-Gaussian. Using two different models we study which effects can influence its shape and how much. In particular, we focus on the parametrizations expressed with the help of Lévy-stable distributions. We show that the Lévy index may deviate substantially from 2 due to non-critical effects such as resonance dec

The Learning with Errors (LWE) problem receives much attention in cryptography, mainly due to its fundamental significance in post-quantum cryptography. Among its solving algorithms, the Blum-Kalai-Wasserman (BKW) algorithm, originally proposed for solving the Learning Parity with Noise (LPN) problem, performs well, especially for certain parameter settings with cryptographic importance. The BKW a

Male butterflies in the hyperdiverse tribe Eumaeini possess an unusually complex and diverse repertoire of secondary sexual characteristics involved in pheromone production and dissemination. Maintaining multiple sexually selected traits is likely to be metabolically costly, potentially resulting in trade-offs in the evolution of male signals. However, a phylogenetic framework to test hypotheses r

The Genomic Medicine Sweden (GMS) initiative aims to strengthen precision medicine across the country. This will be accomplished through the implementation of large-scale sequencing techniques in Swedish healthcare. With a patient-centered view, initial efforts will focus on rare diseases, cancer, pharmacogenomics, and infectious diseases, and subsequently extend to complex diseases. GMS is being

Since the demand for raw material is still growing, historical mining dumps are in the focus of geophysical investigations because they can still bear valuable minerals. Moreover, the risk assessment of groundwater contamination due to solutions processes within slag dumps is an important part of dump characterisations. One suitable technique to use is the spectral induced polarisation (SIP) metho

Spectral information from induced polarisation (IP) measurements can be used for several applications as the characterisation of the lithology, the estimation of hydraulic parameters, the localization of contaminated areas and many more.So far, the spectral content has been mainly determined in frequency domain (FD). Due to significant instrumental developments and advanced data processing and inv

BACKGROUND: Emerging data support the use of thymidine kinase 1 (TK1) activity as a prognostic marker and for monitoring of response in breast cancer (BC). The long-term prognostic value of TK1 kinetics during neoadjuvant chemotherapy is unclear, which this study aimed to elucidate. METHODS: Material from patients enrolled to the single-arm prospective PROMIX trial of neoadjuvant epirubicin, docet

Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are caused by a combination of genetic, environmental and lifestyle factors. This complex etiology creates challenges when it comes to diagnostics, follow-up programs and treatment. Although exact disease mechanisms are yet to be elucidate

Spectral induced polarization (SIP) is an increasingly interesting technique for field investigations since it can provide valuable information on the properties of the subsurface deposits or groundwater units. Field measurements can be carried out in the frequency domain (FD) or in the time domain (TD) but should lead to the same spectral subsurface description. IP measurements are superimposed b

Background: There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted. Methods: Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modelled outcomes for 1,217 disease categories including 70

The surface area of a building that could potentially be used for Building Integrated Photovoltaics would increase dramatically with the availability of transparent solar cells that could replace windows. The challenge is to capture energy from outside the visible region (UV or IR) while simultaneously allowing a high-quality observation of the outside world and transmitting sufficient light in th

Objectives Most indices of disease activity in SLE combine physicians' assessments and laboratory tests. However, there is also a need to capture patients' perspectives of disease activity. Consequently, we need new, preferably quick and easy instruments to collect this information, which can be very useful for online consultations and registry purposes. We compared patients' assessments of SLE di

The carbon cycle of tropical terrestrial vegetation plays a vital role in the storage and exchange of atmospheric CO2. But large uncertainties surround the impacts of land-use change emissions, climate warming, the frequency of droughts, and CO2 fertilization. This culminates in poorly quantified carbon stocks and carbon fluxes even for the major ecosystems of Africa (savannas and tropical evergre