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Background: The pathological process in Alzheimer’s disease (AD) probably starts decades before the onset of symptoms and the clinical AD diagnosis. In patients with AD, the level of cerebrospinal fluid (CSF) amyloid-β1-42 (Aβ42) is usually lower, and the levels of total tau (T-tau) and phosphorylated tau (P-tau) higher than in healthy elderly people. However, the cutoffs differ between studies an

Human stature is a variable often used to study health changes in present and past populations. In this study possible differences in stature from the late Mesolithic-Early Bronze Age, based on skeletal data from southern Sweden, are investigated. The sample comprises n = 203 femora where maximum lengths were evaluated using non-parametric testing. Sex was assessed primarily using criteria on the

Personality is generally considered to be biologically founded in temperament, and temperamental qualities have proven to be relatively stable across childhood and into adulthood (Caspi, Roberts & Shiner,). Temperament predicts important developmental outcomes such as academic performance (Muris,), and social functioning (Eisenberg, Fabes, Guthrie & Reiser,), and it has also been found to

The stable fly, Stomoxys calcitrans (Diptera: Muscidae), is a worldwide pest of livestock. Recent outbreaks of stable flies in sugarcane fields in Brazil have become a serious problem for livestock producers. Larvae and pupae found inside sugarcane stems after harvesting may indicate that stable flies use these stems as potential oviposition or larval development sites. Field observations suggest

This study investigated the influence of five El Niño-Southern Oscillation (ENSO) types on rainy-season precipitation in China: central Pacific warming (CPW), eastern Pacific cooling (EPC), eastern Pacific warming (EPW), conventional ENSO and ENSO Modoki. The multi-scale moving t test was applied to determine the onset and withdrawal of rainy season. Results showed that the precipitation anomaly c

Land management for carbon storage is discussed as being indispensable for climate change mitigation because of its large potential to remove carbon dioxide from the atmosphere, and to avoid further emissions from deforestation. However, the acceptance and feasibility of land-based mitigation projects depends on potential side effects on other important ecosystem functions and their services. Here

Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations from our recent fourth GForce-PD meeting. Stem cell-based therapies for Parkinson'

Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb pair with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard mode

The special issue zooms in on knowledge dynamics that drive innovation processes and new path development in different regional and sectoral contexts. This investigation rests on the differentiated knowledge base approach, which offers a clear distinction between analytical, synthetic and symbolic types of knowledge and deep insights into their idiosyncrasies. The introduction frames knowledge bas

It has been argued that competitive elite sport both a) reduces the humanity of athletes by turning them into beings whose sole value is determined in relation to others, and b) is motivated by a celebration of the genetically superior and humiliation of the weak. This paper argues that while a) is a morally reproachable attitude to competition, it is not what competitive elite sport revolves arou

Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of fli

Advanced combustion concepts like partially premixed combustion (PPC) are sensitive to inlet gas conditions especially inlet temperature. To estimate the combustion parameters like ignition delay on a cycle-to-cycle basis, both complementary filter and extended Kalman filter were designed to estimate the inlet temperature, and the ignition delay was calculated with properly estimated temperature.

Flow patterns for water-butanol, water-toluene and waterhexane two-phase flows were visualized in the cross-shaped junctions of three square glass microchannels with hydraulic diameters of 200 μm, 400 μm and 600 μm. Typical flow pattern maps for water-butanol two-phase flow were developed based on Capillary number of the continuous phase and Weber number of the dispersed phase, and compared with a

The contemporary book business is both globalized and digitalized, whether we are talking international bestsellers or micropublished digital-only e-books. All categories of literature have been profoundly marked by technological and social change. Despite being polar opposites, large-scale media conglomerate publishing and micropublishing are discussed jointly in the article. Globalization and diThe contemporary book business is both globalized and digitalized, whether we are talking international bestsellers or micropublished digital-only e-books. All categories of literature have been profoundly marked by technological and social change. Despite being polar opposites, large-scale media conglomerate publishing and micropublishing are discussed jointly in the article. Globalization and di

The effects of H2 addition on a premixed methane-air flame was studied experimentally with a swirl-stabilized gas turbine model combustor. Experiments with 0%, 25%, and 50% H2 molar fraction in the fuel mixture were conducted under atmospheric pressure. The primary objectives are to study the impacts of H2 addition on flame lean blowout (LBO) limits, flame shapes and anchored locations, flow field

Lactobacillus reuteri metabolises glycerol efficiently to form 3-hydroxypropionic acid (3-HP) and 1,3-propanediol (1,3PDO) by the same mechanism as that for 1,2-propanediol (1,2PDO) conversion to propionic acid and propanol via its propanediol utilization (pdu) pathway. Pdu enzymes are encoded by the pdu-operon, which also contain genes encoding the shell proteins of the microcompartment housing t