Background:Transcriptomic profiles have shown promise as predictors of response to neoadjuvant chemotherapy in breast cancer (BC). This study aimed to explore their predictive value in the advanced BC (ABC) setting.Methods:In a Phase 3 trial of first-line chemotherapy in ABC, a fine needle aspiration biopsy (FNAB) was obtained at baseline. Intrinsic molecular subtypes and gene modules related to i

In recent years, the increase of the global incidence of obesity and obesity-related disorders has been associated with metabolic imbalance and low grade inflammation. Fat-rich meals and diets contribute importantly to those alterations. The aim of this work was to evaluate the impact of exchanging butter by Hass avocado-oil on postprandial metabolic parameters in healthy overweight volunteers con

We present a non-resonant, dual band circular polarization selective structure (CPSS) for satellite communication applications in the K- and Ka-band. The structure consists of multiple layers of cascaded anisotropic sheets, with printed meander lines, separated by low permittivity spacers. It reflects right hand circular polarization and transmits left hand circular polarization in the lower freque

Microcapsules with specific functional properties, related to the capsule wall and core, are highly desired in a number of applications. In this study, hybrid cellulose microcapsules (1.2 ± 0.4 μm in diameter) were prepared by nanoengineering the outer walls of precursor capsules. Depending on the preparation route, capsules with different surface roughness (raspberry or broccoli-like), and thereb

The study investigates inequalities in access to social capital based on social class origin and immigration background and examines the role of transnational ties in explaining these differences. Social capital is measured with a position generator methodology that separates between national and transnational contacts in a sample of young adults in Sweden with three parental backgrounds: at least

Direct conversion of human somatic cells to induced neurons (iNs), using lineage-specific transcription factors has opened new opportunities for cell therapy in a number of neurological diseases, including epilepsy. In most severe cases of epilepsy, seizures often originate in the hippocampus, where populations of inhibitory interneurons degenerate. Thus, iNs could be of potential use to replace t

We identify, through a change of variables, solution operators for evolution equations with generators given by certain simple first-order differential operators acting on Fock spaces. This analysis applies, through unitary equivalence, to a broad class of supersymmetric quadratic multiplication-differentiation operators acting on L2.Rn/ which includes the elliptic and weakly elliptic quadratic op

Biodeterioration challenges range from poor indoor air quality and exterior marble defacing to more dangerous building degradation. People often change the look of degraded walls by painting over them, removing carpets as well as replacing damaged wood and papers to improve their aesthetic value. Due to a lack of public awareness and health care infrastructure, the degradation rate is increasing i

In present paper, the debates around mediatization and transnationalism constitute the backdrop for a discussion on the media and communication practices among Swedish expatriates in the Netherlands and forced migrants from Bosnia in Sweden. The complex relationship between (transnational) identity, place and mobility is studied at three intersections between media and migration: (1) creativity an

Background: Approximately 15–20% of ulcerative colitis patients and 20–40% of those with Crohn’s disease experience extraintestinal manifestations (EIMs) of their inflammatory bowel disease (IBD). Clinicians who treat IBD must manage EIMs affecting multiple organs that variably correlate with intestinal disease activity. Vedolizumab is a monoclonal antibody for the treatment of IBD with a gut-sele

The paper is about finding the global optimum for a wheel loader work cycle in a gravel application. This includes simulating the gravel and extracting the trajectories for the main actuators; propulsion, lift and tilt, during the work cycle. The optimal control method is dynamic programming and the optimum is calculated with regard to fuel efficiency [ton/l] but can be weighted towards productivi