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Epistatic mutations under divergent selection govern phenotypic variation in the crow hybrid zone

The evolution of genetic barriers opposing interspecific gene flow is key to the origin of new species. Drawing from information on over 400 admixed genomes sourced from replicate transects across the European hybrid zone between all-black carrion crows and grey-coated hooded crows, we decipher the interplay between phenotypic divergence and selection at the molecular level. Over 68% of plumage va

What determines unemployment in the long run? : Band spectrum regression on ten countries, 1913-2016

This paper presents an empirical analysis of the relation between un-employment and macroeconomic performance. A strong correlation hasbeen pointed out before, but a crucial question is over what time-horizonthis holds. To the best of our knowledge, no previous cross-country studyhas shown that there is a long-run relationship between unemploymentand macroeconomic performance over a time-period th

The Future of EU Criminal Justice Policy and Practice : Legal and Criminological Perspectives

EU criminal justice is a fast developing and challenging area of EU law and policy that requires scholars from different disciplines to join forces. This book is a first attempt to establish such synergies. Coming from different angles, the authors deal with questions in the area of EU substantive criminal law, such as when criminalisation of conduct is an appropriate choice; how the process of (d

The ecological forecast horizon, and examples of its uses and determinants

Forecasts of ecological dynamics in changing environments are increasingly important, and are available for a plethora of variables, such as species abundance and distribution, community structure and ecosystem processes. There is, however, a general absence of knowledge about how far into the future, or other dimensions (space, temperature, phylogenetic distance), useful ecological forecasts can

Stories of Violence : A Narrative Criminological Study of Ambiguity

Violence features in human life, not only as actual physical confrontation but also as stories. Stories of violence are particularly important in violence-prone subcultures and among those partaking in the illegal drug economy. Drawing on narrative analysis, this study examines stories of violence among a population of incarcerated Norwegian drug dealers. Four widespread story types are identified

Music and substance preferences among festival attendants

Purpose: This article aims to determine the prevalence of substance use among young festival-goers and the associations between preferences for different types of music and recent use of different types of licit and illicit drugs. Design/methodology/approach: The article is based on a cross-sectional survey of 1,787 young adults attending a music festival in Denmark. Associations between preferenc

Young tourists visiting strip clubs and paying for sex

Little is known about young adults' use of strip clubs and prostitution during their holidays abroad. This study examined this issue with a sample of 1125 Danish tourists between the ages of 16 and 34, and sought data about the frequency with which they paid for sex and attended strip clubs while they were on holiday. The tourists were surveyed at a Bulgarian airport before their return trip home.

A robust method for calibration of eye tracking data recorded during nystagmus

Eye tracking is a useful tool when studying the oscillatory eye movements associated with nystagmus. However, this oscillatory nature of nystagmus is problematic during calibration since it introduces uncertainty about where the person is actually looking. This renders comparisons between separate recordings unreliable. Still, the influence of the calibration protocol on eye movement data from peo

Magnetic storms disrupt nocturnal migratory activity in songbirds

Birds possess a magnetic sense and rely on the Earth's magnetic field for orientation during migration. However, the geomagnetic field can be altered by solar activity at relative unpredictable intervals. How birds cope with the temporal geomagnetic variations caused by solar storms during migration is still unclear. We addressed this question by reproducing the effect of a solar storm on the geom

Ciprofloxacin does not inhibit mitochondrial functions but other antiboitics do

At clinical concentrations, ciprofloxacin did not inhibit mitochondrial DNA replication, oxidative phosphorylation, protein synthesis, or mitochondrial mass (transmembrane potential). No difference in supercoiled forms of DNA was observed. The tetracyclines and chloramphenicol inhibited protein synthesis at clinically achievable concentrations, while rifampin, fusidic acid, and clindamycin did not

Risk factors for development of neurocognitive disorders

AbstractVascular risk factors are believed to be involved in dementia development by increasing risk of the most common dementia types, Alzheimer’s disease (AD) and vascular dementia. The aim of this thesis was to study if risk factorsaffect key brain pathology directly, by using biomarkers for dementia in preclinical stages, and to assess previous findings in a large population-based setting.PapeVascular risk factors are believed to be involved in dementia development by increasing risk of the most common dementia types, Alzheimer’s disease (AD) and vascular dementia. The aim of this thesis was to study if risk factors affect key brain pathology directly, by using biomarkers for dementia in preclinical stages, and to assess previous findings in a large population-based setting.Paper I: ar

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later

Objective To evaluate the effect of midlife lipid levels on Alzheimer brain pathology 20 years later in cognitively normal elderly individuals.Methods This is a longitudinal cohort study of 318 cognitively normal individuals with data on fasting lipid levels at midlife (mean age 54 years). Presence of β-amyloid (Aβ) and tau pathologies 20 years later (mean age 73 years) were detected by quantifyin

Ecotypic divergence in Crepis tectorum (Asteraceae): inferring trait lability and correlational constraints from hormonally manipulated phenotypes

Despite long‐standing interest in the evolutionary role of plant hormones, relatively few studies have used hormonally manipulated phenotypes to address questions about phenotypic evolution in plants. In the present investigation, I subjected plants of Crepis tectorum subsp. pumila to simple gibberellin (GA) treatments under both field and greenhouse conditions to assess developmental lability andDespite long‐standing interest in the evolutionary role of plant hormones, relatively few studies have used hormonally manipulated phenotypes to address questions about phenotypic evolution in plants. In the present investigation, I subjected plants of Crepis tectorum subsp. pumila to simple gibberellin (GA) treatments under both field and greenhouse conditions to assess developmental lability and

Defective exocytosis and processing of insulin in a cystic fibrosis mouse model

Cystic fibrosis-related diabetes (CFRD) is a common complication for patients with cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). The cause of CFRD is unclear, but a commonly observed reduction in first-phase insulin secretion suggests defects at the beta cell level. Here we aimed to examine beta- and alpha-cell function in th

Serving God and Mammon: The ‘Minerals-Railway Complex’ and its effects on colonial public finances in the British Cape Colony, 1810-1910

The resource curse literature underscores the fact that extractive economies face challenges in diversifying their economies. What is less explored are the public finance challenges encountered in these economies when the extractive industries are completely privatized. Using a recently compiled dataset on public revenues, expenditures and debt, this paper explores the nexus between the privatized

Sustainable AI : An inventory of the state of knowledge of ethical, social, and legal challenges related to artificial intelligence

This report is an inventory of the state of knowledge of ethical, social, and legal challenges related to artificial intelligence conducted within the Swedish Vinnova-funded project “Hållbar AI – AI Ethics and Sustainability”, led by Anna Felländer. Based on a review and mapping of reports and studies, a quantitative and bibliometric analysis, and in-depth analyses of the health care sector, the tThis report is an inventory of the state of knowledge of ethical, social, and legal challenges related to artificial intelligence conducted within the Swedish Vinnova-funded project “Hållbar AI – AI Ethics and Sustainability”, led by Anna Felländer. Based on a review and mapping of reports and studies, a quantitative and bibliometric analysis, and in-depth analyses of the healt- care sector, the t