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Compound heterozygosity for strong hypomorphic mutations in the PRKN gene is a common cause of autosomal familial Parkinson's disease (PD). We generated an iPSC cell line from the fibroblasts of a PARKIN protein-deficient early-onset PD female patient, carrying genomic deletions of exon 2 and exons 5–7. This line displays characteristic human iPSC morphology and expression of pluripotency-associat

Arid regions in Central Asia face persistent and increasing water scarcity, with groundwater serving as the primary source for drinking water, irrigation, and industry. The effective exploration and management of groundwater resources are critical, but are constrained by limited monitoring infrastructure and complex hydrogeological settings. This study investigates the Akbakay aquifer, a represent

Loess-palaeosol sequences (LPS) are among the most continuous terrestrial archives of Quaternary climate change. Their widespread distribution, high accumulation potential, and sensitivity to environmental variability make them critical for reconstructing past dust fluxes, wind regimes, and regional ecosystem responses. However, the reliability of such reconstructions is fundamentally constrained

Multiple myeloma (MM) is the second most common blood malignancy, with several lines of evidence supporting an inherited genetic component. Here, we sequenced 177 affected individuals from 128 families, and 170 early-onset MM cases diagnosed before 55 years of age. Samples were identified and collected through nationwide efforts in France, Sweden, and Greece. We focused on rare germline protein tr

The aim of this workshopreport is to move beyond existing academicdiscussions on environmental politics in North and EastSyria3, and to respond directly to the region’s urgentenvironmental needs and challenges, and to explorepossible pathways for ecological recovery and justice.We seek to critically examine the political, social, andecological dimensions of environmental governancein post-conflict

In this chapter, I describe how acceptance- and mindfulness-based strategies can be integrated into insomnia treatment. The chapter consists of four main sections. The first section introduces these strategies, examines the scientific/theoretical rationale for their use, provides a review of the empirical evidence, and highlights the importance of personalizing treatment. The second and third sect

Dupljaja loess-palaeosol sequence in southeasternmost sector of the Banat Loess Plateau (Serbia), situated in the southeastern Carpathian (Middle Danube) Basin, is important for understanding the evolution of the Last Glacial climate and southeastern Carpathian as a potential corridor for human migration throughout Europe. The Dupljaja loess-palaeosol sequence in the southeasternmost sector of the

In this study, we investigated overbank sediments of the first terrace of Sava river in Šabac, exposed at a residential building construction site. Sediment characteristics such as grain size, magnetic susceptibility, chemical composition, and loss on ignition (LOI) at 550 °C and 950 °C were determined at 5 cm resolution, accompanied by visual inspection to assess color, pedogenic structure, and o

We investigate how the anchoring effect—a well-established cognitive bias—influences subjective belief distributions. While prior research extensively examines the impact of anchoring and other biases on point estimates, their effect on the underlying distribution and its higher moments remains unexplored. Using two pre-registered online experiments (N = 1467) and two elicitation methods, we find

Despite the centrality of economic theories (including political economic theories) in human geographic research, there is a massive shortage of courses covering this topic in many human geography departments. In this paper, we use the example of a third-semester elective MSc course in political economic theory designed for students in human geography to contribute to this point. The course aims t

Background: Despite substantial progress in the field of mass spectrometry, there remain barriers to measuring the extracellular vesicles (EVs) proteome in blood plasma. Recent work has shown that isolating EVs can make it possible to detect proteins that have low abundance in plasma. Commonly used EV isolation methods either require large sample volumes and long ultracentrifugation times, or else

Indonesia faces a severe plastic pollution crisis driven by extensive plastic usage and inadequate waste management. To effectively address this issue and promote sustainable circularity, it is crucial to understand the dynamics of plastic production, use, and end-of-life management, as well as the interactions among stakeholders throughout the plastics lifecycle. Without such a comprehensive unde

The fate of the Fermi surface in bulk electron-doped Sr2IrO4 remains elusive, as does the origin and extension of its pseudogap phase. Here, we use high-resolution angle-resolved photoelectron spectroscopy (ARPES) to investigate the electronic structure of Sr2−xLaxIrO4 up to x = 0.2, a factor of two higher than in previous work. We find that the antinodal pseudogap persists up to the highest dopin

Model-based design is an emerging tool for dealing with the uncertain dynamic loads entering wastewater treatment plants (WWTPs). But our understanding about the load-driving population-dynamics is limited. Therefore, we studied if mobility data (mobile telecommunications data) could be used to reduce uncertainties during design. Mobility data from Uppsala, Sweden between 2019–2022 clearly quantif

Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c

Cigarette smoke (CS), a major driver of lung cancer (LC), promotes epithelial-mesenchymal transition (EMT) and stemness resulting in metastasis, therapy resistance, and recurrence, but the precise mechanism is elusive. Building on our earlier identification of Runt related transcription factor-2 (RUNX2) and Galectin-3 (Gal-3) as mediators of CS-induced EMT, in this study, we aimed to identify a po

Background: Neoadjuvant therapy is protective of postoperative pancreatic fistula in pancreatoduodenectomy. However, the effect of neoadjuvant therapy after left pancreatectomy remains unclear. The aim of this international multicenter study was to evaluate the impact of neoadjuvant therapy on short term outcomes after left pancreatectomy for pancreatic ductal adenocarcinoma. Methods: Patients und