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Objective To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA). Methods In the SWEFOT trial, patients with RA with symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until the 3-4-month visit. The primary outcome measure was the DAS28-based European League against Rheumatism (EULAR) response criteria. Multivariate logistic r

Inter-pigment interactions define the functioning of light-harvesting protein complexes. To describe the particularly complex molecular dynamics and interactions of peridinin and chlorophyll in the peridinin chlorophyll protein of Amphidinium carterae, we applied global and target analysis to a series of ultrafast transient absorption experiments. We have created and validated a model that consist

Physical inactivity has been identified as the fourth leading risk factor for global mortality and healthcare systems play a major role in increasing physical activity among the population. Physical activity on prescription (PAP) is a non-pharmacological method used in Swedish healthcare to prevent and treat disease. Primary health care is the first level of care, in a strong position to work for

Understanding the mechanisms of deformation and failure of soils is essential in geotechnical engineering. In particular, strain localisation is a key issue for the failure of soils. In laboratory mechanical testing, localised deformation can be investigated efficiently through full-field measurements of displacement and strain in soil specimens. The objective of this study is to investigate the d

ESA's Soil Moisture and Ocean Salinity (SMOS) mission has been designed to extend our knowledge of the Earth's water cycle. Soil Moisture and Ocean Salinity records brightness temperatures at the L-band, which over land are sensitive to soil and vegetation parameters. On the basis of these measurements, soil moisture and vegetation opacity data sets have been derived operationally since 2009 for a

This article proceeds from a critical reading of the role of religion for nation-building in India. In particular, the authors discuss how the Indian notion of secularism relies upon a number of religious legacies manifest in a Gandhian notion of what constitutes religious and political communities. Proceeding from this general picture, the authors examine how Hindu nationalists have used such leg

Sammanfattning I Skåne odlas 34 500 ha sockerbetor för sockerutvinning och i Sverige 36 000 ha (Jordbruksstatistik årsbok 2014). Vid insamling och rötning av blasten från betorna i Skåne skulle drygt 200 GWh biogas kunna produceras per år och driva minst 19 000 bilar eller 1000 bussar. Men idag lämnas den i fält. Tidigare studier har visat att betblast från sockerproduktion är på gränsen till löns

Aim: Solid tumours constitute 40% of childhood malignancies. The Swedish Childhood Cancer Registry is population-based and includes all children with cancer reported from the six paediatric oncology centres in Sweden. The aim was to investigate incidence and survival. Methods: We used the new WHO ICCC-3 for reclassification of the patients. Incidence and survival analyses were performed in the stu

In high-energy heavy-ion collisions, the correlations between the emitted particles can be used as a probe to gain insight into the charge creation mechanisms. In this Letter, we report the first results of such studies using the electric charge balance function in the relative pseudorapidity (Delta eta) and azimuthal angle (Delta phi) in Pb-Pb collisions at root s(NN) = 2.76 TeV with the ALICE de

Measurements of the ZZ and WW final states in the mass range above the [Formula: see text] and [Formula: see text] thresholds provide a unique opportunity to measure the off-shell coupling strength of the Higgs boson. This paper presents constraints on the off-shell Higgs boson event yields normalised to the Standard Model prediction (signal strength) in the [Formula: see text], [Formula: see text

Plant communities differ in their species composition, and, thus, also in their functional trait composition, at different stages in the succession from arable fields to grazed grassland. We examine whether aerial hyperspectral (414–2501 nm) remote sensing can be used to discriminate between grazed vegetation belonging to different grassland successional stages. Vascular plant species were recorde

Background Today, dislocated femoral neck fractures are commonly treated with a cemented hip arthroplasty. However, cementing of the femoral component may lead to adverse effects and even death. Uncemented stems may lower these risks and hydroxyapatite (HA) coating may enhance integration, but prosthetic stability and clinical outcome in patients with osteoporotic bone have not been fully explored

We present spatial and dynamic information on the s = 1/2 distorted kagome antiferromagnet volborthite, Cu3V2O7(OD)(2) center dot 2D(2)O, obtained by polarized and inelastic neutron scattering. The instantaneous structure factor, S(Q), is dominated by nearest-neighbor pair correlations, with short-range order at wave vectors Q(1) = 0.65(3) angstrom(-1) and Q(2) = 1.15(5) angstrom(-1) emerging belo