Background/Aims: Increasing evidence suggests a link between brain-derived neurotrophic factor (BDNF) and suicidal behaviour (SB). Furthermore, decreased peripheral BDNF levels have been associated with clinical symptoms in various psychiatric disorders as well as with personality dimensions in healthy individuals. However, the relationship between BDNF and psychopathology is poorly investigated r

In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of chimeric spectra or sample complexity characterization. Feature detection is difficult because of the high complexity of MS proteomics data from biologi

Background Transcatheter aortic valve replacement (TAVR) has become an established therapeutic option for patients with symptomatic, severe aortic valve stenosis (AS) who are ineligible or at high risk for conventional valvular surgery. In Northwestern Europe, the TAVR technology is also increasingly used to treat patients with an intermediate risk profile. Methods and results The study was design

Creating bimodal grain size distribution in crystalline materials is an effective strategy to improve structural efficiency. Present investigation demonstrates that further control over topology through the formation of bimodal 'harmonic' structure simultaneously increases average values of strength and ductility, reduces the variation of corresponding properties, and thwarts the localization of p

One of the most effective methods for obtaining bulk ultrafine-grained materials is severe plastic deformation that is typically done using equal channel angular pressing. In this work we describe and analyze a new method for obtaining severe plastic deformations proposed by the first author. The method is based on direct extrusion and was called "twist extrusion" The main idea of the method is to

High-cyclic fatigue life in ultra-fine grained materials fabricated by equal channel angular pressing (ECAP) suffers from a specific shear texture induced during the fabrication as has been demonstrated in the present study on the example of pure copper. This texture promotes orientation of the easy glide crystallographic planes to be aligned parallel to the shear plane in ECAP. If specimens for t

The 19th century was a period of great transformations for Italy. Political unification was achieved in 1861 while economic unification was still far off. Ever since, Italian industrialization has been unbalanced, as the pre-existing gap between Northern and Southern economic development has widened. In this context, the creation of the Italian national market has been a highly debated topic. Orig

This paper presents a straightforward method to convert non-uniformly sampled data to uniform samples in order to be processed by some off-line techniques such as system identification. In such scenarios, we deal with a finite-length measurement sequence. We assume periodic extension of the signals, which results in a simple system of linear equations. Furthermore, we take into account a number of

This paper discusses the importance of global-local linkages for the development of indigenous production in cultural clusters by analyzing the interplay between the indigenous film production cluster in Toronto, Canada, and Hollywood's runaway productions. Global-local linkages are at the forefront of the current debate in cluster studies, the discussion has so far had only a limited impact on th

Could an even larger push for women empowerment be a viable development strategy for developing countries? A large literature relates the bargaining power of women to improved health and education of their children (Majlesi, 2015; Qian, 2008; Bobonis, 2009; Duflo, 2003; Lundberg, Pollak and Wales, 1997). However, it remains a challenge to find a good proxy for bargaining power that truly reflects

Objective: Women with active sunlight exposure habits experience a lower mortality rate than women who avoid sun exposure; however, they are at an increased risk of skin cancer. We aimed to explore the differences in main causes of death according to sun exposure. Methods: We assessed the differences in sun exposure as a risk factor for all-cause mortality in a competing risk scenario for 29 518 S

Prospective studies examining the association between coffee and tea consumption and gastric cancer risk have shown inconsistent results. We investigated the association between coffee (total, caffeinated and decaffeinated) and tea consumption and the risk of gastric cancer by anatomical site and histological type in the European Prospective Investigation into Cancer and Nutrition study. Coffee an