The role of salt inducible kinases in the regulation of the mammalian target of rapamycin pathway in adipocytes
Salt inducible kinase 2 (SIK2) is found abundantly in adipose tissue and may have a role in the development of diabetes. SIK2 is downregulated in insulin-resistant and obese individuals, thereby providing a new potential target for therapeutic solutions. Dysfunctional adipose tissue is observed in obesity and this is correlated with impaired insulin signalling, which might contribute to imbalanced