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Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study.

Levodopa is the most effective therapy for Parkinson's disease, but chronic treatment is associated with the development of potentially disabling motor complications. Experimental studies suggest that motor complications are due to non-physiological, intermittent administration of the drug, and can be reduced with continuous delivery. We aimed to assess efficacy and safety of levodopa-carbidopa in

Lower vitamin D levels are associated with depression among community-dwelling European men

Low serum 25-hydroxyvitamin D (25(OH)D) and elevated parathyroid hormone (PTH) Levels have been linked with depressive symptoms among adults in various clinical settings. Data in generally healthy, community-dwelling individuals remain inconclusive. We investigated whether depression was associated with 25(OH)D and/or PTH in a sample of middle-aged and older men (n = 3369; mean age 60 +/- 11) part

The Relationship Between Working Memory Capacity and Students' Behaviour in a Teachable Agent-Based Software

The current study investigated if and how students' behaviour when using a teachable agent-based educational software were related to their working memory capacity. Thirty Swedish students aged 11-12, participated in the study. Results showed that differences in behaviour such as time spent on an off-task activity, time spent on interactive dialogues, and the number of tests that students let thei

Enzyme adsorption on SO2 catalyzed steam-pretreated wheat and spruce material

Lignocellulose is widely recognized as a Sustainable substrate for biofuels production, and the enzymatic hydrolysis is regarded as a critical step for the development of ail effective process for the conversion of cellulose into ethanol. One key factor affecting the overall conversion rate is the adsorption capacity of the cellulase enzymes to the surface of the insoluble substrate. Pretreatment

Manipulating the Dynamics of Self-Propelled Gallium Droplets by Gold Nanoparticles and Nanoscale Surface Morphology

Using in situ surface-sensitive electron microscopy performed in real time, we show that the dynamics of micron-sized Ga droplets on Ga P(111) can be manipulated locally using Au nanoparticles. Detailed measurements of structure and dynamics of the surface from microns to atomic scale are done using both surface electron and scanning probe microscopies. Imaging is done simultaneously on areas with

Food management in tourism: Reducing tourism's carbon 'foodprint'

Food production and consumption have a range of sustainability implications, including their contribution to global emissions of greenhouse gases (GHGs). As some foodstuffs entail higher GHG emissions than others, managing their use in tourism-related contexts could make a significant contribution to climate change mitigation. This article reviews the carbon intensity of selected foods and discuss

Prognostic impact of COX-2 in non-small cell lung cancer: A comprehensive compartment-specific evaluation of tumor and stromal cell expression.

Cyclooxygenase-2 (COX-2) is an enzyme that has been extensively investigated as a prognostic marker in cancer. In non-small cell lung cancer (NSCLC) previous results regarding the prognostic impact of COX-2 expression are inconsistent. Therefore we evaluated the association between transcript levels and overall survival in nine publicly available gene expression data sets (total n = 1337) and dete

The diffusion of fired bricks in Hellenistic Europe : a similarity network analysis

In this study, similarity networks are used to analyse the diffusion of fired bricks across Hellenistic Europe, initiated in the north Aegean in the fourth century BCE. In a similarity network, archaeological contexts with similar attributes are connected according to a predefined criterion, and the edges are interpreted as potential social or causal links. Here we allow any kind of similarity rel

Performance and robustness trade-offs in PID control

Control design is a rich problem which requires consideration of many issues such as load disturbance attenuation, set-point tracking, robustness with respect to process variations and model uncertainty, and effects of measurement noise. The purpose of this paper is to provide insight into the trade-offs between performance and robustness explicitly. This is accomplished by introducing plots that

Mapping of noise risk zones derived from religious activities and perceptions in residential neighbourhoods in the Cape Coast metropolis, Ghana

Ambient noise levels emanating from religious activities in residential neighbourhoods are an emerging environmental problem that educes little attention from enforcement agencies and policy makers in Ghana. This paper set out to quantify religious noise exposure in urban residential neighbourhoods in the Cape Coast metropolis of Ghana. Subjective annoyance levels of residents in selected communit

Ultrasound-induced acoustophoretic motion of microparticles in three dimensions

We derive analytical expressions for the three-dimensional (3D) acoustophoretic motion of spherical microparticles in rectangular microchannels. The motion is generated by the acoustic radiation force and the acoustic streaming-induced drag force. In contrast to the classical theory of Rayleigh streaming in shallow, infinite, parallel-plate channels, our theory does include the effect of the micro

Condensation and evaporation heat transfer characteristics in horizontal smooth, herringbone and enhanced surface EHT tubes

An experimental investigation was performed to evaluate convective condensation and evaporation of R22, R32 and R410A inside a smooth tube (inner diameter 11.43 mm), a herringbone tube (fin root diameter 11.43 mm) and a newly developed enhanced surface EHT tube (inner diameter 11.5 mm) at low mass fluxes. The inner surface of the EHT tube is enhanced by dimple/protrusion and secondary petal arrays

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

Genetic susceptibility accounts for similar to 35% of all colorectal cancer (CRC). Ten common low-risk variants contributing to CRC risk have been identified through genome-wide association studies (GWASs). In our GWAS, 610 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were co

On the equations of motion in constrained multibody dynamics

The equations of motion for a constrained multibody system are derived from a continuum mechanical point of view. This will allow for the presence of rigid, as well as deformable, parts in the multibody system together with kinematical constraints. The approach leads to the classical Lagrange-d'Alembert equations of motion under constraint conditions. The generalized forces appearing in the equati

Acoustic trapping as a generic non-contact incubation site for multiplex bead-based assays.

In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi

Moving from ’gut feeling’ to ’pure facts’: launching the ASI interview as part of in-service training for social workers.

Several standardized assessment instruments have been introduced in social work in the last ten years. One of them, the Addiction Severity Index (ASI), is used today in the Swedish social services, and in the Prison and probation services. Swedish state authorities make strong declarations to implement the ASI-interview while critics are sceptic to both its practical relevance and epistemological

Limitations in the Use of Unipolar Charging for Electrical Mobility Sizing Instruments: A Study of the Fast Mobility Particle Sizer

A comparison between three different types of particle sizing instruments (fast mobility particle sizer, FMPS; electrical low pressure impactor, ELPI; and scanning mobility particle sizer, SMPS) and one condensation particle counter (CPC) was made to compare instrument response in terms of size distributions and number concentration. Spherical oil droplets in 39 different sizes, with geometric mea