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RIFM fragrance ingredient safety assessment, menthyl isovalerate CAS Registry Number 16409-46-4
Asthma referrals : A key component of asthma management that needs to be addressed
Heterogeneity of asthma and difficulty in achieving optimal control are the major challenges in the management of asthma. To help attain the best possible clinical outcomes in patients with asthma, several guidelines provide recommendations for patients who will require a referral to a specialist. Such referrals can help in clearing the uncertainty from the initial diagnosis, provide tailored trea
RIFM fragrance ingredient safety assessment 2-heptylcyclopentanone, CAS Registry Number 137-03-1
Adjustable mini-sling compared with conventional mid-urethral slings in women with urinary incontinence. A randomized controlled trial
Introduction: The primary aim of this study was to compare the objective and subjective outcomes and short-term complication rates of an adjustable single-incision mini-sling (SIMS) vs. standard mid-urethral slings (SMUS). The secondary aim was to report pain perception and complications at the one-year follow up. Material and methods: The study was designed as a multicenter prospective randomized
Parenting and parenting support in Germany and Sweden: Convergence and persistent dissimilarities
Parenting support constitutes a long-established part of both the Swedish and the German portfolio of public social services. It originated in the 1920s in Germany, the 1930s in Sweden. Support measures and underlying philosophies have steadily changed in both countries, thereafter. The 1990s saw a new ‘turn to parenting’ and also new measures in Sweden and Germany. In this article, we ask how par„Parenting“ und „Parenting Support“ in Deutschland und Schweden. Konvergenz und fortdauernde Unterschiede.
Fluorescence microscopy of nanochannel-confined DNA
Stretching of DNA in nanoscale confinement allows for several important studies. The genetic contents of the DNA can be visualized on the single DNA molecule level and both the polymer physics of confined DNA and also DNA/protein and other DNA/DNA-binding molecule interactions can be explored. This chapter describes the basic steps to fabricate the nanostructures, perform the experiments and analy
New Social Risk Policies for German and Swedish Families
Until very recently, Germany belonged to the ‘familialist’ group of welfare states, which offered cash rather than services to married couples and families. Sweden, in contrast, belonged to the ‘non-familialist’ counterpart, fostering gender equality in employment and family care via public services and extended reconciliation measures for decades. During the 2000s, however, Germany eventually enaAbstractUntil very recently, Germany belonged to the ‘familialist’ group of welfare states, which offered cash rather than services to married couples and families. Sweden, in contrast, belonged to the ‘non-familialist’ counterpart, fostering gender equality in employment and family care via public services and extended reconciliation measures for decades. During the 2000s, however, Germany eventu
Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer
Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clini
IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits
The SNP variant rs2943650 near IRS1 gene locus was previously associated with decreased body fat and IRS1 gene expression as well as an adverse metabolic profile in humans. Here, we hypothesize that these effects may be mediated by an interplay with epigenetic alterations. We measured IRS1 promoter DNA methylation and mRNA expression in paired human subcutaneous and omental visceral adipose tissue
The prevalence, incidence, and progression of hand osteoarthritis in relation to body mass index, smoking, and alcohol consumption
Objective. To estimate the extent that overweight/obesity, smoking, and alcohol are associated with prevalence and longitudinal changes of radiographic hand osteoarthritis (OA). Methods. Participants from the Osteoarthritis Initiative (n = 1232) were included, of whom 994 had 4-year followup data. In analyses on incident hand OA, only persons without hand OA at baseline were included (n = 406). Ou
Natural selection acts on floral traits associated with selfing rate among populations of Mixed-Mating collinsia heterophylla (Plantaginaceae)
Premise of research. A major aim in plant research is to understand the micro-and macroevolutionary processes generating the great diversity of mating systems and floral traits found in flowering plants. Using Collinsia heterophylla, a mixed-mating species in a genus with described variation in selfing rate and associated floral traits among species, we investigated (i) intraspecific selfing rate
KITD816V induces SRC-mediated tyrosine phosphorylation of MITF and altered transcription program in melanoma
The oncogenic D816V mutation of the KIT receptor is well characterized in systemic mastocytosis and acute myeloid leukemia. Although KITD816V has been found in melanoma, its function and involvement in this malignancy is not understood. Here we show that KITD816V induces tyrosine phosphorylation of MITF through a triple protein complex formation between KIT, MITF, and SRC family kinases. In turn,
Automatic Controller Tuning using Relay-based Model Identification
Proportional-integral-derivative (PID) controllers are very common in the process industry. In a regular factory there may be hundreds or thousands of them in use. Each of these controllers needs to be tuned, and even though the PID controller is simple, tuning the controllers still requires several hours of work and adequate knowledge in order to achieve a desired performance. Because of that, ma
Perspective : An extension of the STROBE statement for observational studies in nutritional epidemiology (STROBE-nut): Explanation and elaboration
Nutritional epidemiology is an inherently complex and multifaceted research area. Dietary intake is a complex exposure and is challenging to describe and assess, and links between diet, health, and disease are difficult to ascertain. Consequently, adequate reporting is necessary to facilitate comprehension, interpretation, and generalizability of results and conclusions. The STrengthening the Repo
Hospital comparison of stroke care in Sweden : A register-based study
Background and purpose The objective of this study was to estimate the level of health outcomes and resource use at a hospital level during the first year after a stroke, and to identify any potential differences between hospitals after adjusting for patient characteristics (case mix). Method Data from several registries were linked on individual level: seven regional patient administrative system
Transformed Readings : Negotiations of Cult in Paul, Hebrews, and First Clement
Issues surrounding relationships between different writings and questions regarding literary dependence are ubiquitous in New Testament scholarship. This study aims to answer questions concerning how one is to understand the way that early Christian writers used other Christian writings: Are any typical characteristics discernible regarding the earliest use of Christian writings? Were they memoriz
Clinical utility of risk modelsto refer patients with adnexal masses to specialized oncology care : Multicenter external validation using decision curve analysis
Purpose: To evaluate the utility of preoperative diagnostic models for ovarian cancer based on ultrasound and/or biomarkers for referring patients to specialized oncology care. The investigated models were RMI, ROMA, and 3 models from the International Ovarian Tumor Analysis (IOTA) group [LR2, ADNEX, and the Simple Rules risk score (SRRisk)]. Experimental Design: A secondary analysis of prospectiv
Acquired immune resistance follows complete tumor regression without loss of target antigens or IFNγ signaling
Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression. Here, we report mechanistic evidence of tumoral immune escape in an exemplary clinical case: a patient with metastatic melanoma who developed disease recurrence following an initial, unequivocal radiologic complete regression after T-cell–based
Outcomes of biliary atresia in the Nordic countries - a multicenter study of 158 patients during 2005-2016
Background/purpose: Biliary atresia is the most common reason for newborn cholestasis and pediatric liver transplantation. Even after normalization of serum bilirubin after portoenterostomy, most patients require liver transplantation by adulthood due to expanding fibrosis. We addressed contemporary outcomes of biliary atresia in the Nordic countries. Methods: Data on center and patients character