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Molecular motor-driven filament transport across three-dimensional, polymeric micro-junctions

Molecular motor-driven filament systems have been extensively explored for biomedical and nanotechnological applications such as lab-on-chip molecular detection or network-based biocomputation. In these applications, filament transport conventionally occurs in two dimensions (2D), often guided along open, topographically and/or chemically structured channels which are coated by molecular motors. H

Prolonged function and optimization of actomyosin motility for upscaled network-based biocomputation

A stract Significant advancements have been made towards exploitation of naturally available molecular motors and their associated cytoskeletal filaments in nanotechnological applications. For instance, myosin motors and actin filaments from muscle have been used with the aims to establish new approaches in biosensing and network-based biocomputation. The basis for these developments is a version

Design of network-based biocomputation circuits for the exact cover problem

Exact cover is a non-deterministic polynomial time (NP)-complete problem that is central to optimization challenges such as airline fleet planning and allocation of cloud computing resources. Solving exact cover requires the exploration of a solution space that increases exponentially with cardinality. Hence, it is time- and energy consuming to solve large instances of exact cover by serial comput

Probing surface-sensitive redox properties of VOx/TiO2 catalyst nanoparticles

Redox processes of oxide materials are fundamental in catalysis. These processes depend on the surface structure and stoichiometry of the oxide and are therefore expected to vary between surface facets. However, there is a lack of direct measurements of redox properties on the nanoscale for analysing the importance of such faceting effects in technical materials. Here, we address the facet-depende

Tecknets historicitet : En möbeldetalj och dess meningsskapande variation

Syftet med kapitel är att dels visa på potentialen i att studera även små till synes triviala detaljer i vardagliga objekt, dels att visa på betydelsen av det historiska sammanhanget för den semiotiska analysen. Detta har genomförts utifrån en analys av en för traditionell möbelproduktion vanligt förkommande teknik, nämligen sinkning, i tre olika historiska kontexter med såväl pre- som postindustr

Field-resolved high-order sub- cycle nonlinearities in a terahertz semiconductor laser,

The exploitation of ultrafast electron dynamics in quantum cascade lasers (QCLs) holds enormous potential forintense, compact mode-locked terahertz (THz) sources, squeezed THz light, frequency mixers, and comb-basedmetrology systems. Yet the important sub-cycle dynamics have been notoriously difficult to access in operationalTHz QCLs. Here, we employ high-field THz pulses to perform the first ultr

A thermodynamically consistent Markovian master equation beyond the secular approximation

Markovian master equations provide a versatile tool for describing open quantum systems whenmemory effects of the environment may be neglected. As these equations are of an approximatenature, they often do not respect the laws of thermodynamics when no secular approximation isperformed in their derivation. Here we introduce a Markovian master equation that isthermodynamically consistent and provid

Antiphospholipid antibodies in patients with myocardial infarction with and without obstructive coronary arteries

Background: Recent studies demonstrate that prothrombotic antiphospholipid antibodies (aPL) are overrepresented in patients with myocardial infarction (MI) due to coronary artery disease (MICAD). However, it is not known whether aPL differ between the two subsets of MI: MICAD and MI with nonobstructive coronary arteries (MINOCA). Objectives: To determine whether aPL are associated with MINOCA or M

Training the trainers : Finding new educational opportunities in the virtual world

The COVID-19 pandemic has disrupted scientific gatherings and conferences, opening up opportunities for virtual learning platforms. Realizing the potential of online academic exchanges, the World Psychiatric Association (WPA) also developed virtual avenues and information systems for capacity building of mental health professionals across the world. Among its first such initiatives, the WPA organi

Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hn

Establishment of an immortalized human erythroid cell line sustaining differentiation potential without inducible gene expression system

Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a significant alternative in future transfusion therapies. The ectopic expression of human papilloma virus (HPV) E6/E7 gene has successfully been employed to establish these cell lines. To induce differentiation and maturation of the immortalized cell lines

Expression of protein HC on the plasma membrane of different human cell types

The surface expression of a recently described plasma glycoprotein called human complex-forming glycoprotein, hetergeneous in charge (protein HC) on a number of different human cell types was investigated. By means of direct and indirect immunofluorescence, protein HC was shown to be associated with the surface of virtually all cells of the investigated normal cell types including erythrocytes, pe

Quantitation of J chain in human biological fluids by a simple immunochemical procedure

The molecular form and immunochemical properties of the J chain populations released on reduction and carboxymethylation of normal human plasma, milk, saliva and of plasma containing IgA or IgM M-components were investigated. A procedure was devised to release the entire J chain population from these various sources and to produce immunochemically identical J chain populations containing only J ch

Production of protein HC by human fetal liver explants

Human fetal lever explants were found to secrete protein HC into the medium in molar amounts comparable to those of albumin, alpha 1-antitrypsin and orosomucoid. Incorporation of a radioactive amino acid from the medium into the secreted protein HC demonstrated de novo synthesis. The secreted protein HC had the same size and electrophoretic mobility as protein HC of plasma and urine and gave a rea

Non-secretory or low-secretory myeloma with intracellular kappa chains. Report of six cases and review of the literature

This report concerns six cases of multiple myeloma characterized by either no demonstrable monoclonal immunoglobulin in plasma or urine or by trace amounts (less than or equal to 0.1 g/l) of monoclonal kappa chains in the urine. In all cases there was an infiltration of the bone marrow by plasma cells containing kappa chains but no heavy chains. A retrospective analysis was made of 126 consecutive

Interaction of the Fc part of IgG with Lancefield extracts of hemolytic streptococci. Strain specificity and activity

Lancefield extracts of 19 types of group A streptococci as well as one group C and one group G strain were examined for agglutination of human red cells coated with various anti-Rh antibodies. Fourteen extracts agglutinated one or more of the coated cell samples, while five did not. The agglutination was inhibited by Fc but not by Fab fragments of human IgG. After mouse passages, three of the non-

Demonstration of the non-identity between the Fc receptor for human IgG from group A streptococci type 15 and M protein, peptidoglycan and the group specific carbohydrate

After electrophoresis of an alkaline extract of type 15 group A streptococci, three main precipitation lines were obtained in diffusion experiments against commercial human polyclonal IgG (lines 1, 2 and 3). Nineteen of 23 sera (83%) from apparently healthy human individuals gave line 3, while 6 of them (26%) gave line 1. The sera giving line 1 did also give line 3. Line 2 was obtained with 2 sera