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PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells

Ossifying fibromyxoid tumor (OFMT) is a soft tissue tumor frequently displaying gene fusions, most of which affect the PHF1 gene. PHF1 encodes plant homeodomain finger protein 1, which is involved in various processes regulating gene transcription, including those orchestrated by the polycomb repressor complex 2. Here, a series of 37 OFMTs, including 18 typical, 9 atypical, and 10 malignant varian

Supported education in a Swedish context – Opportunities and challenges for developing career-oriented support for young adults with mental health problems

Young adults experiencing mental health problems often need both individual support and educational accommodations to successfully complete their studies. Recent research also points to the need for career-related, educational services in a labor market that increasingly demands formal education or training. The aim of this study was to investigate the development of supported education services i

Altered body composition profiles in young adults with childhood-onset inflammatory bowel disease

Background: Patients with inflammatory bowel disease (IBD) often develop alterations in body composition in terms of their proportions of lean mass and fat mass, as well as reduced bone mineral density (BMD). However, there are limited data on the skeletal muscle index (SMI) and percentage fat (fat %) for young adults with childhood-onset IBD. Our aim was to investigate the body compositions of th

How Civil Resistance Succeeds (or Not): Micro-dynamics of Unity, Timing, and Escalatory Actions

The article analyzes the micro‐sociological dynamics of civil resistance in the uprisings in Bahrain and Tunisia (2010‐11). It argues that the Tunisian uprising succeeded because regime repression generated solidarity and unity among diverse groups in society, while the regime increasingly suffered from miscommunication, mistrust, and increasing disobedience. In Bahrain, the movement initially enj

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

Although β-amyloid (Aβ) plaques and tau neurofibrillary tangles are hallmarks of Alzheimer's disease (AD) neuropathology, loss of synapses is considered the best correlate of cognitive decline in AD, rather than plaques or tangles. How pathological Aβ and tau aggregation relate to each other and to alterations in synapses remains unclear. Since aberrant tau phosphorylation occurs in amyloid precur

Regulation of NMDA receptor trafficking by amyloid-β

Amyloid-β peptide is elevated in the brains of patients with Alzheimer disease and is believed to be causative in the disease process. Amyloid-β reduces glutamatergic transmission and inhibits synaptic plasticity, although the underlying mechanisms are unknown. We found that application of amyloid-β promoted endocytosis of NMDA receptors in cortical neurons. In addition, neurons from a genetic mou

Stroke in the Long Term. Prognosis, comorbidity, disability, readmission, and the caregiver perspective

Stroke är en mycket vanlig sjukdom och idag räknar man med att det finns över 140 000 drabbade i Sverige som lever med varierande grad av funktionell nedsättning. Prognosen efter stroke påverkas av många olika faktorer varav flera tidigare inte fått så mycket uppmärksamhet. Den här avhandlingen ämnar ge en heltäckande bild av långtidsprognosen och varje delarbete fokuserar på olika viktiga aspekteBackground: Stroke is a major cause of mortality and disability. Prognosis is constantly evolving and is affected by multiple factors, many of which have not previously been thoroughly analyzed. This thesis aims to provide an updated and comprehensive description of long-term prognosis after stroke, specifically exploring key factors such as comorbidity (Study II), pre-stroke functional dependency

Taking Care of Business: A Study of the Governing of Care Choice Systems in Swedish Home Care

This study provides an account of the introduction of care choice systems into the provision of home care by Swedish municipalities. Care choice systems in elder care are at the centre of a conflict about the broader principles of the welfare state. Studying them is thus a way of revealing the outlines of this conflict. In this thesis, I show how the introduction of care choice systems changes the

The internationalization of social work. Emerging discourses from the Erasmus Mundus Advances program

Nowadays, an increased number of international social work (ISW) educational programs have been developed with the goal to equip practitioners to face the social problems in the new modern era. Within our globalized world, social work is in the quest for professionals with a global mind-set and nontraditional abilities and skills. This article pre- sents the findings of an explorative research car

The ESSνSB project

The ESSνSB project aims to produce a neutrino beam of unique intensity for a long-baseline oscillation measurement of CP-violation in the leptonic sector. The project, supported within the H2020 framework programme of the European Union, is currently in a conceptual design study phase, and work is ongoing within the project to develop viable solutions for the upgrade of the linear accelerator of t

SES inequalities in cause-specific adult mortality: a study of the long-term trends using longitudinal individual data for Sweden (1813-2014)

Higher socioeconomic status (SES) is associated with lower mortality, and this correlation has been confirmed using different indicators across several geographical settings. Nevertheless, the timing of the emergence of the SES gradient remains unclear. We used individual-level longitudinal data for a regional population in southern Sweden covering the period between 1813 and 2014, and we applied

Paradoxical increase in nasal airway resistance after topical nasal decongestion - does it really exist? : A retro- and prospective study

OBJECTIVE: To explore the prevalence and reproducibility of paradoxically increased nasal airway resistance after decongestion of the nasal mucosa as well as to identify patient-related factors associated with it.DESIGN: Retrospective analysis of all rhinomanometric measurements carried out at one ENT department in Sweden in the time between 1990 and 2010. In the baseline material, 207 of 4435 pat

Energy Consumption for Securing Lightweight IoT Protocols

In this paper we address the energy consumption of the Constraint Application Protocol (CoAP) and the Message Queue Telemetry Transport (MQTT) protocol and compare their overhead. We also pay attention to the use case of security in IoT and analyze the energy consumption when using TLS/DTLS for the two protocols. In our experiments we use ESP32 with libcoap, MQTT, and mbed TLS libraries and conduc