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Unravelling causes of defects in construction

The purpose of this study is to identify the primary root causes of defects in terms of why they persist in construction, despite the increasing implementation of quality systems. Defects in construction continue to be a source of concern in the construction industry. There have been studies that have tried to identify causes of defects. Although concepts are usually related to organisational fact

The +1444C>T polymorphism in the CRP gene: a study on personality traits and suicidal behaviour.

OBJECTIVES: Numerous studies have shown associations between an on-going depression and elevated serum levels of the acute-phase reactant C-reactive protein (CRP). Also, in suicidal behaviour, a proinflammatory state has been suggested to be of importance for the pathophysiology. There is a genetic susceptibility to suicidal behaviour, but studies with respect to genes related to inflammation are

Polonium-210 and Caesium-137 in lynx (Lynx lynx), wolverine (Gulo gulo) and wolves (Canis lupus).

Wolves, lynx and wolverines are on the top of the food-chain in northern Scandinavia and Finland. (210)Po and (137)Cs have been analysed in samples of liver, kidney and muscle from 28 wolves from Sweden. In addition blood samples were taken from 27 wolves. In 9 of the wolves, samples of muscle, liver and blood were analysed for (210)Po. Samples of liver and muscle were collected from 16 lynx and 1

Social desirability in personality inventories: Symptoms, diagnosis and prescribed cure

An analysis of social desirability in personality assessment is presented. Starting with the symptoms, Study 1 showed that mean ratings of graded personality items are moderately to strongly linearly related to social desirability (Self deception, Impression formation, and the first PC), suggesting that item popularity may be a useful heuristic tool for identifying items which elicit socially desi

Observation of an Excited B_{c}^{±} Meson State with the ATLAS Detector.

A search for excited states of the B_{c}^{±} meson is performed using 4.9 fb^{-1} of 7 TeV and 19.2 fb^{-1} of 8 TeV pp collision data collected by the ATLAS experiment at the LHC. A new state is observed through its hadronic transition to the ground state, with the latter detected in the decay B_{c}^{±}→J/ψπ^{±}. The state appears in the m(B_{c}^{±}π^{+}π^{-})-m(B_{c}^{±})-2m(π^{±}) mass differen

Nature, nurture and socioeconomic policy-What can we learn from molecular genetics?

Many countries use public resources to compensate individuals with genetic disorders, identified by behaviors/symptoms such as chronic diseases and disabilities. This paper draws attention to molecular genetic research which may provide a new dimension to our understanding of how socioeconomic outcomes are generated. We provide an overview of the recently emerging evidence of gene-environment inte

Postgraduate education in internal medicine in Europe

Background: Limited information exists on the framework and content of postgraduate education in internal medicine in Europe. This report describes the results of a survey of postgraduate training in internal medicine in the European countries. Methods: Two online questionnaire-based surveys were carried out by the European Board of Internal Medicine, one on the practice of internists and the othe

Maternal Autoimmune Thyroid Disease and the Fetal Immune System.

OBJECTIVE: Several studies indicate that in utero exposure to maternal autoimmune diseases and transplacental passage of autoantibodies affect the risk of autoimmunity in the offspring, e. g., maternally derived GAD65 autoantibody correlates with decreased risk of type 1 diabetes, whereas thyroid peroxidase autoantibody (TPOAb) positivity at birth is associated with increased incidence of autoimmu

CONVERSION FACTORS FOR ESTIMATION OF EFFECTIVE DOSE IN PAEDIATRIC CHEST TOMOSYNTHESIS.

For chest tomosynthesis in adults, a conversion factor of 0.26 mSv/Gy cm(2) has been reported for calculating the effective dose from the registered dose-area-product. The aim of this study was to determine conversion factors for chest tomosynthesis in children. Using the Monte Carlo-based computer software PCXMC 2.0, simulations were performed on modified phantoms for males and females aged 8-19

miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.

Androgen signalling through the androgen receptor (AR) is essential for prostate cancer initiation, progression and transformation to the lethal castration-resistant state. The aim of this study was to characterize the mechanisms by which miR-145 deregulation contribute to prostate cancer progression. The miR-145 levels, measured by quantitative reverse transcription-polymerase chain reaction, wer

Optimization of a self-closing effect to produce nanochannels with top slits in fused silica

The authors report on the fabrication of subsurfaced 100-600 nm wide nanochannels in fused silica with top slit openings in the size range of 5-10 nm. Such nanochannels can be used in combination with a nanofluidics system to guide molecular motors and quickly switch the chemical environment inside the nanochannels through diffusion via the top slits. To realize nanochannel top slits in this size

Prediction of IgG1 aggregation in solution.

Interest in monoclonal antibody aggregation is increasing as aggregates of biopharma-ceuticals can cause an immunogenic response when injected into the body. In this work a stoichiometric reaction model from concentration-time data is developed to predict the dimer ratio in stored antibody solutions over time. IgG1 was incubated at pH from 4.5 to 5.5, salt concentrations from 100 to 600 mmol/kg an

Isolation of interstitial fluid and demonstration of local proinflammatory cytokine production and increased absorptive gradient in chronic peritoneal dialysis

Rosengren BI, Sagstad SJ, Karlsen TV, Wiig H. Isolation of interstitial fluid and demonstration of local proinflammatory cytokine production and increased absorptive gradient in chronic peritoneal dialysis. Am J Physiol Renal Physiol 304: F198-F206, 2013. First published November 14, 2012; doi:10.1152/ajprenal.00293.2012.-In peritoneal dialysis (PD) patients, the frequent exposure to "unphysiologi

Size Determination of Shear-Induced Multilamellar Vesicles by Rheo-NMR Spectroscopy

A model for analyzing the deuterium (H-2) NMR line shapes of D2O ill surfactant multilamellar vesicle (MLV, "onion") systems is proposed. The assumption of the slow exchange of water molecules between adjacent layers implies that the H-2 NMR line shape is simply given by a SLIM of Lorentzians if the condition of motional narrowing is also fulfilled. Using the classical two-step model for the NMR r

Independent evolution of similar complex cognitive skills : the importance of embodied degrees of freedom

Recent years have seen acknowledgment from a number of researchers that similarities appear to exist in complex cognitive skills of distantly related species – most notably in corvids, parrots, delphinids, and great apes. Discoveries on complex cognitive skills in common hold the promise of interesting and fruitful new perspectives on cognition. That said, some theoretical approaches seem largely

Intratherapeutic Biokinetic Measurements, Dosimetry Parameters Estimate, and Monitoring Treatment Efficacy using Cerenkov Luminescence Imaging in Preclinical Radionuclide Therapy.

In recent years, there has been an increasing amount of interest in non-invasive Cerenkov Luminescence Imaging (CLI) of in vivo radionuclide distribution in small animals, a method proven as a high-throughput modality for confirmation of tracer uptake. 11B6 is an IgG1 monoclonal antibody that is specific for free human kallikrein-related peptidase 2 (hK2) an antigen abundant in malignant prostatic