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The medically important drug target galectin-3 binds galactose-containing moieties on glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface-exposed binding site. All successful inhibitors of galectin-3 to date have been based on mono- or disaccharide cores closely resembling natural ligands. A detailed understanding of the H-bonding networks in these natural liganThe medically important drug target galectin-3 binds galactose-containing moieties on glycoproteins through an intricate pattern of hydrogen bonds to a largely polar surface-exposed binding site. All successful inhibitors of galectin-3 to date have been based on mono- or disaccharide cores closely resembling natural ligands. A detailed understanding of the H-bonding networks in these natural ligan

The Learning with Errors problem (LWE) has become a central topic in recent cryptographic research. In this paper, we present a new solving algorithm combining important ideas from previous work on improving the Blum-Kalai-Wasserman (BKW) algorithm and ideas from sieving in lattices. The new algorithm is analyzed and demonstrates an improved asymptotic performance. For the Regev parameters $q=n^2$

We report a unique case of "aleukemic" skin chloroma located at the place of previous head injury. Chloroma presented as a local livid papulous skin infiltration (5x3cm), whilst physical examination and patient's complete blood counts were normal. Chloroma spontaneously disappeared. One month later, a diagnosis of acute myeloid leukemia was made. We discussed different pathogenetic mechanisms of t

The shaping of a city and its future relates to official decisions made in city planning meetings, where daily planning matters and decision-making processes adapt to changing societal circumstances. The interest of this research lies in how planning is officially established, managed and practiced in the setting of a Jordanian city, and its local districts. This interest leads the research to obs

Laurie Cohen and Joanne Duberley describe their use of an unconventional data source-a radio programme-to study celebrity careers. This source also includes music, which evokes memories, and elicits emotions not readily captured in conventional interviews. They used the archives of the BBC Radio 4 programme Desert Island Discs to study the careers of well-known research scientists. The programme's

The presence of contralateral tactile input can profoundly affect ipsilateral tactile perception, and unilateral stroke in somatosensory areas can result in bilateral tactile deficits, suggesting that bilateral tactile integration is an important part of brain function. Although previous studies have shown that bilateral tactile inputs exist and that there are neural interactions between inputs fr

The choice of hyperparameter(s) notably affects the support recovery in LASSO-like sparse regression problems, acting as an implicit model order selection. Parameters are typically selected using cross-validation or various ad hoc approaches. These often overestimates the resulting model order, aiming to minimize the prediction error rather than maximizing the support recovery. In this work, we pr

Massive multiple-input multiple-output (MIMO) is one of the key candidates for the upcoming 5G wireless generation. It offers a multitude of advantages over traditional techniques, such as reduced latency, reduced interference among user equipments (UEs) and increased spectrum and energy efficiencies. However, to verify the theoretically promised gains in real-life, prototype systems are inevitabl

Much of the current work on third language acquisition focuses on modeling the impact from the speaker’s previous language(s). The Typological Primacy Model (Rothman, 2015), which covers holistic forward transfer at the initial state, and the L2 Status Factor (Bardel and Falk, 2012), which proposes forward transfer from a chronologically true L2, only predict effects on subsequently acquired langu

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are

Context: Both scientific publications and grey literature have widely been employed as sources of empirical evidence in evidence-based software engineering (EBSE). However, there is still a fierce debate about whether or not the pervasive Web content can act as an alternative means to gather evidence for EBSE. Aim: To help ourselves enter this debate, this work aims to obtain some pre-evidence of