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Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducible kinases (SIKs) control subcellular localization of HDAC4/5 and CRTC2. PTH regulates both HDAC4/5
Use of a second harmonic and third harmonic cavity within a klystron to increase efficiency has been studied using particle-in-cell (PIC) code, MAGIC 2D. The six cavity device has a drive frequency of 1GHz, a predicted efficiency of 88%, 39 dB gain and an output power of 833 kW. The preliminary simulation results have revealed indications of bunching with bunch core oscillations. The initial resul
The United Kingdom’s recently updated approach to sustainable drainage enhanced biodiversity and amenity objectives by incorporating the ecosystem approach and the ecosystem services concept. However, cost-effective and reliable methods to appraise the biodiversity and amenity values of potential sustainable drainage system (SuDS) sites and their surrounding areas are still lacking, as is a method
Let (Formula presented.) denote the space of ordinary Dirichlet series with square summable coefficients, and let (Formula presented.) denote its subspace consisting of series vanishing at (Formula presented.). We investigate the weak product spaces (Formula presented.) and (Formula presented.), finding that several pertinent problems are more tractable for the latter space. This surprising phenom
Sediments from the small lake Ilsø situated in the Illerup/Alken Enge Valley were studied in order to investigate past landscape development at the time of a probably ritual human mass burial following battle during the Roman Iron Age (ad 1–400). A pollen record from Ilsø and a number of other records from Jutland were combined using the Landscape Reconstruction Algorithm to reconstruct local vege
Small angle X-ray (SAXS) and neutron scattering techniques were combined to study mixed complexes formed between micelles of the nonionic amphiphilic PEO-PPO-PEO copolymer (P123) and the anionic bile salt (NaGDC) in aqueous solution. The purpose was to investigate the structural parameters of the charged complexes, such as size and internal structure, as well as their interparticle interactions in
In order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theoryIn order to add to the existing knowledge on the complex institutional dynamics of negotiating conflicts and compatibilities in innovation processes that address societal challenges and social needs, this article scrutinizes the scientific and societal debate on the theoretical and practical application of “social innovation” by means of the concept “boundary object” linked to institutional theory
At Helmholtz-Zentrum Berlin (HZB) the end-station PEAXIS (Photo Electron Analysis and X-ray resonant Inelastic Spectroscopy) combining Angle-dependent X-ray Photoelectron Spectroscopy (AdXPS) and Resonant Inelastic X-ray Scattering (RIXS) is currently built. The latter method uses a spherical variable line space (VLS) grating to focus the beam onto the detector. Working in first-order diffraction
Aspects of size, structural (im)perfection, inner density, and guest molecule loading capacity of dendronized polymers (DPs) of high generation (6≤g≤8) in aqueous solution are studied using electron paramagnetic resonance spectroscopy on amphiphilic, spin-labeled guest molecules. The results show that the interior of the charged DPs is strongly polar, especially in comparison to their lower genera
This study sheds light on the causes of failure of economic reform in the Kurdistan Region of Iraq (KRI). It argues that the success of economic reform largely relies on the choices available for ruling authorities as well as their willingness to share power with the people and with each other. Since the birth of the Iraqi state and the KRI the interaction of uncivic traditions, rent seeking, and
The ability of biological molecules to replicate themselves is the foundation of life, requiring a complex cellular machinery. However, a range of aberrant processes involve the self-replication of pathological protein structures without any additional assistance. One example is the autocatalytic generation of pathological protein aggregates, including amyloid fibrils, involved in neurodegenerativ
Denitrification during the sedimentation process in secondary settlers in waste-water treatment plants has been reported to be still a significant problem. The modelling of such a process with the conservation of mass leads to a nonlinear convection–diffusion–reaction partial differential equation, which needs non-standard numerical methods to obtain reliable simulations. The purpose of this study
Background A crucial issue for the sustainability of societies is how to maintain health and functioning in older people. With increasing age, losses in vision, hearing, balance, mobility and cognitive capacity render older people particularly exposed to environmental barriers. A central building block of human functioning is walking. Walking ifficulties may start to develop in midlife and become
SIR—Older people with mobility limitations often report more barriers in their outdoor environment than people with intact mobility [1]. However, it is uncertain whether older people perceive their environment as problematic because of their mobility limitations or whether the environmental barriers precede incident mobility limitation, as most studies have been limited to cross-sectional analyses
Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state
In an attempt to address some long-standing issues of epistemology, Hilary Kornblith proposes that knowledge is a natural kind the identification of which is the unique responsibility of one particular science: cognitive ethology. As Kornblith sees it, the natural kind thus picked out is knowledge as construed by reliabilism. Yet the claim that cognitive ethology has this special role has not conv
English oak (Quercus robur) and European beech (Fagus sylvatica) are amongst the most common tree species growing in Europe, influencing the annual biogenic volatile organic compound (BVOC) budget in this region. Studies have shown great variability in the emissions from these tree species, originating from both genetic variability and differences in climatic conditions between study sites. In thi
This article identifies factors which contribute to households’ willingness to pay for improving and protecting a multiple-use water scheme in Ethiopia. It does so through descriptive statistics, a probit model and contingent valuation methods complemented with qualitative data. Estimates suggest farmers’ willingness to pay is based on gender, the prevalence of waterborne disease, the time to coll
We have investigated, comparatively, the ontogenetic development of the compound eye in larvae of a mysid (Neomysis) and a euphausiid (Thysanoessa) species and found it to be close to identical in the two species. The larval eye is of apposition type with special adaptations for planktonic life. The elongated dioptric apparatus is devoid of screening pigment and instead has a proximal lens optical
