Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated processes, and disruption of this balance may cause several pathologies and contribute to obesity and type 2 diabetes (T2D). This Review summarizes epigenetic signatures obtained from human tissues of relevance for metabolism—i.e., adipose

INTRODUCTION: Resent research has revealed an increased concentration of free fetal hemoglobin (HbF) in maternal serum from patients who subsequently develops preeclampsia (PE). In a previous study of 96 patients we have shown that HbF in combination with the heme-scavenger alpha-1-microglobulin (A1M) are potential predictive biomarkers of PE.OBJECTIVES: In this validating case-control study we ai

Enfaldig förklaring öfwer Lutheri lilla catechismum, stält genom spörsmåhl och swar / aff Olao Swebilio.Utgåva av Sveriges första riksnormerande katekes (1689) med inledning och noter.

We present a simple microfluidic-based synthesis protocol to fabricate snowman like Janus hydrogel particles of poly(N-isopropylacrylamide) (PNIPAM) in micron length scale. Particles are synthesized by emulsifying a hydrogel solution (water (w)/oil (o)) followed by partial solvent evaporation. Solvent evaporation allows the hydrogels to concentrate within the droplet and phase separate into a mono

The purpose of this research is to study the impact of temperature, precipitation, and wind speed on in situ concrete wall operations, and its combined resulting effect on project duration. The research presented is anchored in the learnings gained through a literature review on weather effects on construction operations, an analysis of weather data with high resolution, and two field studies of i

The pulp and paper industry is one of the most important industrial sectors worldwide. The focus of current pulp mills is on the production of cellulose pulp fibres and electricity. By converting traditional pulp mills into lignocellulosic biorefineries they can become a keystone in a future bioeconomy. In order to achieve this, pulp mills have to close their loops and focus on the optimal utilisa

We present a case of a patient in a severe pulmonary mucormycosis during the neutropenic phase of treatment for acute myeloblastic leukaemia (AML), type M2. He had two major risk factors for setting infection; leukaemia and diabetes mellitus. Although he received antimicrobial and antifungal therapy with Amphotericin B in time, it was unable to eradicate infection. We performed a pneumectomy, whic

The ability to generate two-color free-electron laser (FEL) radiation enables a wider range of user experiments than just single-color FEL radiation. There are different schemes for generating the two colors, the original being to use a single bunch and two sets of undulators with different K-parameters. An alternative scheme was recently shown, where two separate bunches in the same RF bucket are

By using the Langevin equation with complex action it is possible to generate (complex) configurations in the charged sector of gauge theories. We test the algorithm in the case of two-dimensional U(1) gauge theory and are able to measure the string tension with great precision and modest use of computer time for a separation of the charged particles where a conventional Wilson loop would have a v

By Monte Carlo calculations on a 124 lattice we investigate four-dimensional SU(2) lattice gauge theory with respect to the conjecture that at large distances this theory reduces approximately to two-dimensional SU(2) lattice gauge theory. We find good numerical evidence for this conjecture. As a by-product we also measure the SU(2) string tension and find reasonable agreement with scaling. The "a

Background: Calcium overload is a major cause of reperfusion myocardial injury. Multidetector computed tomography (MDCT) has been previously used in visualizing coronary artery calcium, but not calcium deposits in reperfused infarction. Purpose: To assess the ability of MDCT to 1) noninvasively visualize and characterize calcium deposits in reperfused infarcts, and 2) monitor regional wall swellin

Searches for dijet resonances with sub-TeV masses using the ATLAS detector at the Large Hadron Collider can be statistically limited by the bandwidth available to inclusive single-jet triggers, whose data-collection rates at low transverse momentum are much lower than the rate from standard model multijet production. This Letter describes a new search for dijet resonances where this limitation is

Compound semiconductors exhibit an intrinsic polarity, as a consequence of the ionicity of their bonds. Nanowires grow mostly along the (111) direction for energetic reasons. Arsenide and phosphide nanowires grow along (111)B, implying a group V termination of the (111) bilayers. Polarity engineering provides an additional pathway to modulate the structural and optical properties of semiconductor

We use the method of a color effective Hamiltonian to study the properties of states in which a gluonic subsystem forms a color singlet, and we will study the possibility that such a subsystem hadronizes as a separate unit. A parton system can normally be subdivided into singlet subsystems in many different ways, and one problem arises from the fact that the corresponding states are not orthogonal