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Inhibition mechanism of human galectin-7 by a novel galactose- benzylphosphate inhibitor

Galectins are involved in many cellular processes due to their ability to bind carbohydrates. Understanding their functions has shown the necessity for potent and specific galectin inhibitors. Human galectin-7 (hGal-7), in particular, has been highlighted as an important marker in many types of cancer by either inhibiting or promoting tumour growth. Producing ligands able to selectively targe

Comparison of serial casting and stretching technique in children with congenital idiopathic clubfoot: Evaluation of a new assessment system.

Background and purpose The outcome of clubfoot treatment is the result of several factors such as severity, type of treatment, and measurement instruments. We compared two intervention groups with two assessment procedures. Patients and methods 16 children were treated consecutively with intensive stretching according to the Copenhagen method and 16 children consecutively with casting according to

Text categorization using predicate-argument structures

Most text categorization methods use the vector space model in combination with a representation of documents based on bags of words. As its name indicates, bags of words ignore possible structures in the text and only take into account isolated, unrelated words. Although this limitation is widely acknowledged, most previous attempts to extend the bag-of-words model with more advanced approaches f

Degradation of dissolved and sorbed 2,4-dichlorophenol in soil columns by suspended and sorbed bacteria.

The influence of sorption of bacteria, as well as 2,4-dichlorophenol (2,4-DCP), on the mineralization of 100 microg l(-1) of the organic compound was examined in an aquifer material under advective flow conditions (column displacement technique). The study was designed to distinguish the rates and extent of biodegradation of the sorbed and the dissolved trace organic and the contribution of sorbed

Maternal use of loperamide in early pregnancy and delivery outcome.

Aim: To study delivery outcome including presence of infant congenital malformations after maternal use of loperamide in early pregnancy. Methods: Using the Swedish Medical Birth Register, women reporting the use of loperamide in early pregnancy were compared with other women for the period July 1, 1995-2004. Odds ratios (OR) or risk ratios (RR) were estimated after adjustment for some variables,

Aerosol particle formation events and analysis of high growth rates observed above a subarctic wetland-forest mosaic

An analysis of particle formation (PF) events over a subarctic mire in northern Sweden was performed, based on number size distributions of atmospheric aerosol particles (10-500 nm in diameter) and ions (0.4-40 nm in Tammet diameter). We present classification statistics for PF events from measurements covering the period July 2005- September 2006, with a break over the winter period. The PF event

Simvastatin Attenuates Hepatic Sensitization to Lipopolysaccharide After Partial Hepatectomy.

BACKGROUND: Hepatic resection may be curative in patients with hepatobiliary malignancies but excessive loss of liver volume may cause hepatic dysfunction and increase susceptibility to subsequent postoperative infections and sepsis. Herein, we hypothesized that pretreatment with simvastatin may protect against lipopolysaccharide (LPS)-induced liver damage after partial hepatectomy. MATERIALS AND

Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.

Context: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. Objective: To evaluate if assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. Design: The Malmö OPRA study is an ongoing longitudinal study. Participants have been evaluated a

Synchronizing Enterprise Resource Planning Systems and Business Processes: A Case of a New ERP Development Approach

Abstract – A major question in organizations is how to synchronize business processes with ICT in order to get the support they need from the adopted technology. Adoption of standardized software packages such as enterprise resource planning (ERP) systems aims at being the solution, demanding that either the system is adjusted to existing business processes or that the business processes are adjus

Differences in Origin of Reactive Microglia in Bone Marrow Chimeric Mouse and Rat After Transient Global Ischemia.

Current understanding of microglial involvement in disease is influenced by the observation that recruited bone marrow (BM)-derived cells contribute to reactive microgliosis in BM-chimeric mice. In contrast, a similar phenomenon has not been reported for BM-chimeric rats. We investigated the recruitment and microglial transformation of BM-derived cells in radiation BM-chimeric mice and rats after

Kvalitetsregistret Riksstroke visar på ojämlik strokevård. : Omedveten diskriminering kanske förklarar en del av skillnaderna.

In this article, results from a series of studies on the relationships between socioeconomic factors and stroke processes (stroke unit care, acute reperfusion treatment, secondary prevention with oral anticoagulants and statins) and outcomes (long-term survival, return to work and risk of suicide and suicide attempts) are summarized. The overall pattern is that acute and secondary prevention inter