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The Road to Maturity - Lineage Commitment in early Hematopoiesis

Popular Abstract in Swedish Benmärgstransplantation är idag en livsavgörande behandling som används vid leukemi, men även andra sjukdomar. Trots att behandlingen funnits sedan 1950-talet medför den fortfarande komplikationer. Den är ibland inte heller tillräckligt effektiv, och nya strategier behöver utvecklas. För att kunna genomföra detta är det av stor betydelse att förstå hur sjukdomarna uppstThe road to maturity – how do hematopoietic stem cells (HSC) differentiate into mature blood cells? The pathways of lineage commitment during normal hematopoiesis are of great significance in order to understand the underlying events that lead to leukemia, and to the design of proper treatments for prevention and remission of the disease. The route of hematopoiesis can be thought of as a hierarchi

Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

Background: Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the neutrophils from C5a activation before they enter the reperfused area, which could be a mechanistic a

Predictors of successful, self-reported lifestyle changes in a defined middle-aged population: The Soderakra cardiovascular risk factor study, Sweden

Aims: It is well established that the main cause of the development of cardiovascular disease can be found in unhealthy lifestyle habits. In our study, we wanted to explore the long-term predictors of self-reported lifestyle changes in a middle-aged population after screening for cardiovascular risk factors 10 years earlier. Methods: We conducted a 10-year follow-up telephone interview on self-rep

The contributions of Ramon y Cajal and other Spanish authors to hypnosis

The authors review the most important Spanish contributions to hypnosis during the 19th and 20th centuries, with emphasis on the work of Santiago Ramon y Cajal, winner of the 1906 Nobel Prize in medicine. It is widely accepted that he provided a basic foundation for modern neurosciences with his work on neuronal staining and synaptic transmission. What is missing in most accounts of his work is hi

Complex Formation of Small Molecules during Isolation in Low Temperature Matrices: Water Dimers in p-H-2 and Ne Matrices

The concentrations of water dimer are compared in Ne and p-H-2 matrices at low temperatures, using infrared spectroscopy. Additional data are given for o-D-2 and Ar matrices. For a given monomer concentration, the dimer concentration is significantly higher in solid Ne (or Ar) than in solid p-H-2. In p-H-2, the dimer concentration is only slightly higher than expected for a random distribution of

Epidemiological studies of severe infections in COPD

It is well known that patients with COPD have an increased risk of lower respiratory tract infections, but less is known about the association with other infections. The aim of this thesis was to explore epidemiological aspects of severe infections in COPD, using public registries in Sweden. In the first study, incidence rates of tuberculosis were compared in all individuals discharged with COPD,

Factors associated with patients self-reported adherence to prescribed physical activity in routine primary health care

Background: Written prescriptions of physical activity have increased in popularity. Such schemes have mostly been evaluated in terms of efficacy in clinical trials. This study reports on a physical activity prescription referral scheme implemented in routine primary health care (PHC) in Sweden. The aim of this study was to evaluate patients' self-reported adherence to physical activity prescripti

Single-shot photofragment imaging by structured illumination

A laser method to suppress background interferences in pump - probe measurements is presented and demonstrated. The method is based on structured illumination, where the intensity profile of the pump beam is spatially modulated to make its induced photofragment signal distinguishable from that created solely by the probe beam. A spatial lock-in algorithm is then applied on the acquired data, extra

Mutual Shading of PV Modules on Flat Roofs: A Parametric Study

In order to make cities more resilient, our urban environment should not only consume energy, it should also become energy producing. Flat roofs are highly suitable for the placement of PV systems to produce renewable energy, but the assessment of its exact energy potential is not straightforward. Important configurations parameters of PV systems are the inclination and row distance, both leading

Long Term Outcome and Prediction Models of Cognition, Activities of Daily Living and Nursing Home Placement in Alzheimer’s Disease with Cholinesterase Inhibitor Treatment

Popular Abstract in Swedish Bakgrund Alzheimers sjukdom (AD) är den vanligaste formen av demenssjukdom och svarar för ca 60 % av dessa patienter. Sjukdomen har en smygande debut och den sjukliga processen i hjärnan börjar troligen decennier innan den ger kliniska symptom som försämrat minne och organisationsförmåga, språksvårigheter, problem med tidsuppfattning och orientering. Även förmågan att uBackground Prospective longitudinal studies in Alzheimer's disease (AD) that include cholinesterase inhibitor (ChEI) treatment in routine clinical settings are scarce. The patients vary in severity of the disease, clinical course, rate of progression and response to treatment. Knowledge about the predicted course of the disease, sociodemographic and clinical factors affecting the outcome and the i

Comment on "The mechanism for activation of GTP hydrolysis on the ribosome".

Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely

New Relativistic Atomic Natural Orbital Basis Sets for Lanthanide Atoms with Applications to the Ce Diatom and LuF3

New basis sets of the atomic natural orbital (ANO) type have been developed for the lanthanide atoms La-Lu. The ANOs have been obtained from the average density matrix of the ground and lowest excited states of the atom, the positive ions, and the atom in an electric field. Scalar relativistic effects are included through the use of a Douglas-Kroll-Hess Hamiltonian. Multiconfigurational wave funct

The influence of feed flow channel diameter on frictional pressure drop, membrane performance and process cost in full-scale tubular ceramic membranes

Tubular ceramic membranes with many, small-diameter feed flow channels have the advantage of being less costly per unit membrane area. For this reason, membranes with many small channels are often favored over those with fewer larger channels. We have theoretically studied how the diameter of the feed flow channels influences the frictional pressure drop, the membrane performance (flux and retenti

Stomatal uptake of O-3 in aspen and aspen-birch forests under free-air CO2 and O-3 enrichment

Rising atmospheric carbon dioxide (CO2) may alleviate the toxicological impacts of concurrently rising tropospheric ozone (O-3) during the present century if higher CO2 is accompanied by lower stomatal conductance (g,), as assumed by many models. We investigated how elevated concentrations of CO2 and O-3, alone and in combination, affected the accumulated stomatal flux of O-3 (AFst) by canopies an

Complexation between DNA and surfactants and lipids: phase behavior and molecular organization

The interaction between DNA and various cationic species, e. g. cationic surfactant (CS), has a broad biological and biotechnological significance. In the cell nucleus as well as in transfection formulations, other species, mainly zwitterionic lipids, are also present but their exact role needs elucidation. A closer investigation of the stability of structures formed as well as the molecular arran

Mg I emission lines at 12 and 18 mu m in K giants

Context. The solar mid-infrared metallic emission lines have already been observed and analyzed well, and the formation scenario of the Mg I 12 mu m lines has been known for more than a decade. Detections of stellar emission at 12 mu m have, however, been limited to Mg I in very few objects. Previous modeling attempts have been made only for Procyon and two cool evolved stars, with unsatisfactory

Towards a conceptual framework of place attractiveness: a migration perspective

Abstract in UndeterminedThe attractiveness of places is currently gaining a high policy salience in policymakers’ efforts to draw mobile capital. Yet, while there are a growing number of empirical studies considering the migration of people and the attractiveness of places, there is an acute lack of conceptual understanding of the phenomena that hamper discussions between researchers and policymak

Automatic Partitioning and Simulation of Weakly Coupled Systems

Many control engineering tasks nowadays rely on the simulation of complex multi-physics systems. Modern tools allow to build the required dynamic models conveniently, thanks to Object-Oriented Modelling languages, e.g., Modelica, and to perform simulations with hardly any additional effort on the part of the analyst. However, when simulation speed is of concern, the same tools fall short of exploi

Quality and lean health care: a system for assessing and improving the health of healthcare organisations

The purpose of this article is to present and discuss the development of a system for assessing and improving healthcare organisations. The system components comprise (1) a framework or model for assessing, measuring, diagnosing and improving healthcare organisations, (2) a simple methodology for data collection, data analysis and prioritising improvement areas and (3) an index named ILL (innovati