We have studied the reaction mechanism for the insertion of Mg2+ and Fe2+ into a porphyrin ring with density functional calculations with large basis set and including solvation, zero-point and thermal effects. We have followed the reaction from the outer-sphere complex, in which the metal is coordinated with six water molecules and the porphyrin is doubly protonated, until the metal ion is insert

The bismuth spectrum emitted from a hollow cathode discharge has been recorded with a Fourier Transform Spectrometer (FTS). Accurate wavelengths have been determined for 104 lines, and several new energy levels have been found, while the accuracy of previously known level energies have been improved. The hyperfine structure of all observed lines has been analyzed, yielding hyperfine constants A an

The current Spark Ignited (SI) engine equipped with three-way catalyst offers low emissions, but has low efficiency at part load, which results in unnecessarily high CO2 emissions. The Compression Ignited (CI) engines have higher efficiency and hence lower CO2 emissions, but suffer from higher Nitrogen Oxide (NOx) and Particulate Matter (PM) emissions, and no three-way catalyst can be used. Large

A novel radioimmunoassay of type-specific M antigens on whole group A streptococcal cells is described. Absorbed rabbit anti-M antisera directed against M types 12 and 49 were used for determining M antigens on intact bacterial organisms. Staphylococcal protein A labelled with 125I was used as an anti-antibody reagent. The absorbed antisera were tested against ten homologous and 48 heterologous se

OBJECTIVES: To examine pioglitazone as add-on to metformin and insulin secretagogues in patients with type 2 diabetes and inadequate glycaemic control and its effect on glycaemic control, surrogate measures of insulin sensitivity (adiponectin) and beta-cell function (proinsulin/insulin) and fluid retention.DESIGN AND SETTING: Prospective open-label study of 54 patients with type 2 diabetes and HbA

The finely-tuned increases and decreases in the intracellular calcium levels in myocytes ultimately regulate the contraction and relaxation of the heart. Therapeutic agents can improve or interfere with this delicate balance. Calcium sensitizers enhance cardiac contraction by improving the use of calcium that is available, rather than by inundating the cell with excessive calcium, as is the case w

Purpose: While we have recently detected neuronal nitric oxide synthase (nNOS) immunoreactivity in a heterogeneous population of human male urethral striated muscle, to our knowledge the association of nNOS in the female counterpart is unknown. We investigated the association of nNOS with female urethral striated muscle and re-investigated muscle fiber types. Materials and Methods: Cryostat sectio

We studied the effect of hyperbaric oxygen treatment on axonal outgrowth in grafts of sciatic nerves in 40 rats. The sciatic nerve was transsected and a 10 mm long segment from the opposite side was immediately sutured in as a nerve graft. Postoperatively 17 animals were treated with 100% oxygen at 3.2 atmospheres absolute pressure for 45 minutes and the treatment was repeated at four and eight ho

Popular AbstractBarnomsorg- och skolakommittén fick i augusti 1996 uppdraget att utarbeta ett samlat måldokument för förskolans s.k. sexårsverksamhet och för det obligatoriska skolväsendet. I de två betänkandena –Växa i lärande (SOU 1997:21) och Att erövra omvärlden (SOU 1997:157) – anknyter kommittén till 1946 års skolkommissions tankar om skolans inre arbete, i sin vision av den svenska skolans This thesis is mainly about the life and work of the Austrian teacher and psychologist Elsa Köhler (1879-1940), but also about the work of her followers on the Swedish West coast. It traces the influences of pedagogic progressivism and the Central European school-reform movements, on the Swedish school and pre-school system, during the first half of the 20th century. These ideas as laid down in th

The isolation and characterization of six human cysteine proteinase inhibitors is reported. Their distribution in human biological fluids is also described and discussed with respect to physiological function. Studies on kininogen and cystatin C with respect to structure-function relationships and, as a result of the cystatin C studies, a general model for the mechanism of cysteine proteinase inhi

Twenty-three patients with clinically suspected acute or chronic osteomyelitis and 21 patients with suspected joint prosthetic infection underwent scintigraphy using both 99mTc-nanocolloid and 111In-labeled leukocytes. The scintigrams of the two tracers were blindly interpreted by three independent observers. Their evaluations showed high correspondence. Patients were classified as having no infec

We hypothesised that pieces of nerve that are normally trimmed away during graft repair could be a source of Schwann cells and used to create an autologous cell-containing nerve graft. To test the idea a transsection injury was made on the rat sciatic nerve. Seven days later, pieces from the proximal and distal stumps were used for the immediate isolation of its non-neuronal cells. These cells, of

Object. With increasing use of endovascular procedures, the number of aneurysms treated surgically will decline. in this study the authors review complications related to the surgical treatment of aneurysms and address the issue of maintaining quality standards on a national level. Methods. A prospective, nonselected amalgamation of every aneurysm case treated in five of six neurosurgical centers

OBJECTIVE: To describe the epidemiology of and risk factors for severe chickenpox in Guinea- Bissau. METHODS: A prospective household study in a semiurban area of the capital. Severity was assessed by number of pox, fever response and presence of pneumonia. Severity was compared for the first case in a house, that is, the index case, and the secondary cases infected at home. RESULT: We identified