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Evaluation of the GARD assay in a blind cosmetics Europe study
Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using anim
Effects of Different Type of Gasoline Fuels on Heavy Duty Partially Premixed Combustion
The effects of fuel properties on the performance and emissions of an engine running in partially premixed combustion mode were investigated using nine test fuels developed in the gasoline boiling point range. The fuels covered a broad range of ignition quality and fuel chemistry.The fuels were characterized by performing a load sweep between 1 and 12 bar gross IMEP at 1000 and 1300 rpm. A heavy d
The GARD platform for potency assessment of skin sensitizing chemicals
Contact allergy induced by certain chemicals is a common health concern, and several alternative methods have been developed to fulfill the requirements of European legislation with regard to hazard assessment of potential skin sensitizers. However, validated methods, which provide information about the potency of skin sensitizers, are still lacking. The cell-based assay Genomic Allergen Rapid Det
Pareto-optimal reversed-phase chromatography separation of three insulin variants with a solubility constraint
With the shift of focus of the regulatory bodies, from fixed process conditions towards flexible ones based on process understanding, model-based optimization is becoming an important tool for process development within the biopharmaceutical industry. In this paper, a multi-objective optimization study of separation of three insulin variants by reversed-phase chromatography (RPC) is presented. The
The Effect of Intake Temperature in a Turbocharged Multi Cylinder Engine Operating in HCCI Mode
The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in The operating range in HCCI mode is limited by the excessive pressure rise rate and therefore high combustion induced noise. The HCCI range can be extended with turbocharging which enables increased dilution of the charge and thus a reduction of combustion noise. When the engine is turbocharged the intake charge will have a high temperature at increased boost pressure and can then be regulated in
Billions at stake in climate finance: four key lessons
Experimental analysis of stone wool sandwich composites exposed to constant incident heat fluxes and simulated parametric fires
An experimental analysis of the fire behavior of stone wool composites with stainless steel and gypsum plasterboard linings was performed. The focus was to characterize the micro-scale behavior of stone wool, and identify the main processes occurring in stone wool composites when exposed to heat. Thermogravimetric analysis was applied to two different wools with varying densities and binder conten
Using Hythane as a Fuel in a 6-Cylinder Stoichiometric Natural-gas Engine
Combination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burnCombination of right EGR rates with turbocharging has been identified as a promising way to increase the maximum load and efficiency of heavy duty spark-ignited natural gas engines. With stoichiometric conditions a three way catalyst can be used which means that regulated emissions can be kept at very low levels. However dilution limit is limited in these types of engines because of the lower burn
Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A
Endothelial progenitor cells (EPCs) contribute to neovasculogenesis and reendothelialization of damaged blood vessels to maintain the endothelium. Dysfunction of EPCs is implicated in the pathogenesis of vascular injury induced by homocysteine (Hcy). We aimed to investigate the role of Cyclin A in Hcy-induced EPCs dysfunction and explore its molecular mechanism. In this study, by treatment of EPCs
Bedömning av neurologisk prognos efter hjärtstopp : Uppdaterade rekommendationer från Svenska HLR-rådets expertgrupp
Assessment of neurologic prognosis after cardiac arrest. Updated recommendations from the Swedish CPR Council Expert Group European Resuscitation Council (ERC) issued updated guidelines for postresuscitation care in 2015. This paper provides updated Swedish recommendations for neurological prognostication of patients remaining unconscious after cardiac arrest (CA). The prognostication should be ba
RIFM fragrance ingredient safety assessment, (Z)-4-hepten-1-ol, CAS Registry Number 6191-71-5
RIFM fragrance ingredient safety assessment, 3-tert-butylcyclohexyl acetate, CAS Registry Number 31846-06-7
Ingvar Svennilson on Economic Planning in War and Peace
During the transition from a wartime to a peacetime economy in the mid-1940s, Sweden experienced a heated debate on economic planning in which a number of Sweden’s leading economists were involved. In 1941, Ingvar Svennilson, a member of the so-called Stockholm school of economists, became the head of the Industrial Institute of Economic and Social Research, founded by Swedish industry. During the
Introducing Environmental Historians to the History of Knowledge : The Circulation of Environmental Knowledge in Sweden 1967
Competition of cooperation? "Somalinomics" in the UK
The purpose of this article is (a) to review scholarly literature on entrepreneurship among Somalis in the United Kingdom and (b) through a field survey among Somali entrepreneurs in the UK assess if the prevailing image – derived from (a) – is valid or if some additional observations may alter the picture. Step (b) is accomplished through interviews with 36 Somalia-born entrepreneurs, most of the
Somaliska stigfinnare: Fem företagare berättar
Den somaliafödde företagaren är en i Sverige mindre vanlig uppenbarelse. Det beror knappast på att somalier i allmänhet skulle sakna ”företagaranda”. Det förhåller sig nämligen tvärtom. De flesta somalier i diasporan kommer från miljöer där någon i familjen eller släkten haft en butik, restaurang eller importfirma. Och i många länder där somaliska flyktingar de senaste årtiondena slagit sig ner ha
Som att bestiga Mount Everest. Om filmutbildning och filmproduktionslandskapet
Formosanska språk, relativisering och språktypologi
Gustaf Fröding som teaterkritiker
Artikeln presenterar tre aspekter av Gustaf Frödings verksamhet som teaterkritiker under åren 1888-1894: för det första hans recensioner i Karlstads-Tidningen av dramatiska arbeten som getts ut i bokform, för det andra hans signerade teaterrecensioner i Karlstads-Tidningen, och för det tredje osignerade teaterrecensioner i Karlstads-Tidningen som kan ha skrivits av Fröding.
