Myelin is essential for the mammalian brain to function efficiently. Whilst many factors have been associated with regulating the differentiation of oligodendroglia and myelination, glutamate signalling might be particularly important for learning-dependent myelination. The majority of myelinated projection neurons are glutamatergic. Oligodendrocyte precursor cells receive glutamatergic synaptic i

Measurements of the hygroscopic properties of sub-micrometer atmospheric aerosol particles were performed with hygroscopic tandem differential mobility analysers (H-TDMA) at 5 sites in the subtropical north-eastern Atlantic during the second Aerosol Characterization Experiment (ACE-2) from 16 June to 25 July 1997. Four of the sites were in the marine boundary layer and one was, at least occasional

The ACE-2 HILLCLOUD experiment was carried out on the island of Tenerife in June-July 1997 to investigate the interaction of the boundary layer aerosol with a hill cap cloud forming over a ridge to the north-east of the island. The cloud was used as a natural flow through reactor to investigate the dependence of the cloud microphysics and chemistry on the characteristics of the aerosols and trace

A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q

We trace the development of neo-institutional theory in Organization Studies from a marginal topic to the dominant theory. We show how it has evolved from infancy, through adolescence and early adulthood to being a fully mature theory, which we think is now facing a mid-life crisis. Some of the features of this mid-life crisis include over-reach, myopia, tautology, pseudo-progress and re-inventing

Aims: It has in recent years been established that epigenetic changes contribute to β-cell dysfunction and type 2 diabetes (T2D). For example, we have showed that the expression of histone deacetylase 7 (HDAC7) is increased in pancreatic islets of individuals with T2D and that increased levels of Hdac7 in β-cells impairs insulin secretion. The HDAC inhibitor MC1568 rescued this secretory impairmen

For many applications, including future giant telescopes, there is increased interest in structural cables. Usually integrated models, i.e. combined models of structures, optics and control systems are used for modeling of telescopes. Performance of structural cables is non-linear, so often a linearization is needed to include cable models in integrated models of telescopes. We present two differe

Objective: To evaluate the test–retest reliability of the Life Satisfaction Questionnaire (LiSat-11) and the association between items in individuals with chronic stroke. Design: Test–retest design. Subjects: Forty-five individuals (mean age 65 years) with mild to moderate disability at least 6 months post-stroke. Methods: LiSat-11, which includes 1 global item”Life as a whole” and 10 domain-speci

We report on an experimental demonstration of spatially-resolved detection of atomic hydrogen in flames using a single-ended configuration yielding 656-nm lasing in the backward direction upon 2-photon pumping with 205-nm femtosecond laser pulses. Spatial resolution is achieved by temporally-resolved detection of the backward lasing using a streak camera. The method is demonstrated in CH4/O2 flame

Animal signals involved in sexual selection are often indicators of individual quality. The assumption that sexual characters such as breeding plumage may indicate immune state has rarely been tested in free-living migratory birds, particularly in relation to innate immunity. If sexual characters indeed reflect immune condition, then these could be used to evaluate individual quality. Melanin is a

Background and Policy Context: Previous chapters in this book have explored several product-oriented policies, including mandatory laws and product energy labelling, and discussed the importance of an appropriate policy mix. In this chapter, we examine the effects of demand-side policies, with a focus on green public procurement (GPP). GPP has been defined as ‘a process whereby public authorities

In 1736 Samuel Hesselius, former pastor for the Swedish parishes in Pennsylvania, donated a collection of ‘American curiosities’ to Lund University in Sweden. Within less than twenty years, however, the collection had apparently disappeared. In the course of the past three decades the lost ethnographic artefacts have received increasing attention, but for a variety of reasons the collection has reIn 1736 Samuel Hesselius, former pastor for the Swedish parishes in Pennsylvania, donated a collection of ‘American curiosities’ to Lund University in Sweden. Within less than twenty years, however, the collection had apparently disappeared. In the course of the past three decades the lost ethnographic artefacts have received increasing attention, but for a variety of reasons the collection has re

Indolecarboxamidotetrazole compounds are well known as potential anti allergic agents due to their mast cell stabilizing activity on human basophils. A quantitative structure activity relationship (QSAR) model has been generated using Multiple Linear regression (MLR) for the prediction of inhibition efficiency of indolecarboxamidotetrazole derivatives. Twenty-one compounds with their activities ex

A laser-based technique for recording absolute air-fuel ratio maps in a single-laser pulse in combustion devices, for instance, prior to ignition in internal combustion engines, is demonstrated. The method is based on an in situ pulse-to-pulse calibration of two-dimensional laser-induced fluorescence (LIF) images of relative fuel distributions by a point Raman measurement. A single excimer laser p

STED Nanoscopy of Interfaces and Interactions between Nanostructure Arrays and Living Cells The specific arrangement of membrane lipids and proteins in a living cell at the interface to high-aspect ratio nanostructures (nanowires and nanostraws) is still unknown – as are the dynamic structural adaptations and molecular rearrangements of living cells in the vicinity of such nanostructures. Whether

A schematic mechanistic box model presenting processes in atmospheric chemical cycles is used to present the main research objectives. From this the main use of PIXE within atmospheric chemistry is discussed. An analytic system giving molecular composition is necessary to fully understand and quantify the chemical and physical pathways described in the model for different compounds. Combining PIXE

The district heating (DH) customer installations in current DH systems contain a variety of different faults that cause the return temperatures of the systems to increase. This is a major problem, since the focus in theDH sector is to decrease the system temperatures in order to utilize more low-temperature heat. Therefore, this study has focused on how utilities are currently working to keep theiThe district heating (DH) customer installations in current DH systems contain a variety of different faults that cause the return temperatures of the systems to increase. This is a major problem, since the focus in the DH sector is to decrease the system temperatures in order to utilize more low-temperature heat. Therefore, this study has focused on how utilities are currently working to keep the

Introduction: Recovery following distal radius fracture (DRF) is generally achieved within six months. However, a minority of patients experience functional impairments over a longer period. Traditional outcome measures are grip strength and range of movement. However, this may not reflect all parameters that are important. This study focuses on grip function as well as occupational performance in