Neurons derived from neural stem cells could potentially be used for cell therapy in neurodegenerative disorders, such as Parkinson's disease. To achieve controlled differentiation of neural stem cells, we expressed transcription factors involved in the development of midbrain dopaminergic neurons in rat and human neural progenitors. Using retroviral-mediated transgene delivery, we overexpressed L

Denna rapport är en redovisning av den intervjuundersökning som genomfördes under Äldre, Boende, Design projektets första etapp. Innehållet är organiserat efter fyra frågeställningar: Hur ser det moderna urbana äldrelivet ut? Hur beskriver deltagarna sin relation till den tekniska utvecklingen i allmänhet och till utvecklingen av informations- och kommunikationstekniken i synnerhet? I vilket av

Protein structure-function relationships can be studied by using linker insertion mutagenesis, which efficiently identifies essential regions in target proteins. Bacteriophage Mu in vitro DNA transposition was used to generate an extensive library of pentapeptide insertion mutants within the alpha-complementing domain 1 of Escherichia coli beta-galactosidase, yielding mutants at 100% efficiency. E

En intervju med sociologen Saskia Sassen om globaliseringen, liberalismen och demokratin.

Telecommunications industries are investing tremendously to meet the ever-increasing demands for higher data rates and capacity. In particular to develop standardization for 5G, which is expected around 2020. The existing spectrum for traditional mobile networks is limited to highly occupied bands at microwave frequencies below 6 GHz. It is expected that 5G will use millimeter-waves to enable high

Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplastic anemia, characterized by macrocytic anemia, reticulocytopenia, and severely reduced numbers of erythroid precursors in the bone marrow. For more than fifty years, glucocorticoids have remained the main option for pharmacological treatment of DBA. While continuous glucocorticoid administration increases hemoglobin levels in a major

Lewis' concept of admissibility was introduced as an integral part of his famous Principal Principle; the principle that initial rational/reasonable belief should conform to objective chance unless there is evidence to the contrary. At that time Lewis offered only the rough and ready characterisation that evidence not to the contrary of such dependence is admissible. This, together with some suffi

Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph(-)) cell population. A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid l

Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). Further