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An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia

The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied. Here we present a combined investigation of the typology, protein-based species composition, and absolute chronology of Maglemosian bone points. The majority of the bone points are mad

NOMI after cardiac arrest. Could refined diagnostics improve outcome?

Intestinal ischaemia is usually classified into acute mesenteric ischaemia (AMI), chronic mesenteric ischaemia and colonic ischaemia. Coeliac, inferior and superior mesenteric arterial/venous emboli/thrombi and non-occlusive mesenteric ischaemia (NOMI) can cause AMI. NOMI pathophysiology involves hypoperfusion, aggravated by bacterial translocation, reperfusion injury, apoptosis and decreased prol

Systemic phenotype related to primary Sjögren's syndrome in 279 patients carrying isolated anti-La/SSB antibodies

OBJECTIVES: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on

Running on Air : Radio and the Experience of Drama in the Swedish ‘Gunder Hägg mania’ of 1941–45

During World War II, middle-distance runner Gunder Hägg set 15 world records and became a media sport star of unprecedented magnitude in Sweden. This article turns attention to the role of radio broadcasts in the formation of Swedish “Hägg mania” 1941–45. When analyzed in terms of blindness, liveness and co-presence, radio broadcasts from this era reveal that radio announcers actively engaged with

Är vetenskapen modernitetens prästerskap?

Det har länge varit en kliché att vetenskapen utgör det nutida samhällets andliga stånd. Men vad betyder det, och hur väl håller denna metafor?Även om det kan ligga något i bilden av ett vetenskapligt prästerskap, är det också viktigt att notera på vilka sätt den är vilseledande. Forskare finner det ofta fåfängt att försöka nå Sanningen. I stället försöker de förkasta det som är falskt. På så sätt

Health care utilisation among older people with Down syndrome compared to specific medical guidelines for health surveillance : a Swedish national register study

Background: Specific medical guidelines for health surveillance exist for people with Down syndrome (DS) since 25 years but knowledge of adherence to the guidelines is lacking. The guidelines were developed to avoid unnecessary suffering from preventable conditions. The aims of the study were to investigate 1) planned health care visits in relation to the co-morbidities described in specific medic

A novel function for CDK2 activity at meiotic crossover sites

Genetic diversity in offspring is induced by meiotic recombination, which is initiated between homologs at >200 sites originating from meiotic double-strand breaks (DSBs). Of this initial pool, only 1-2 DSBs per homolog pair will be designated to form meiotic crossovers (COs), where reciprocal genetic exchange occurs between parental chromosomes. Cyclin-dependent kinase 2 (CDK2) is known to locali

Identification of Inflammatory and Disease-Associated Plasma Proteins that Associate with Intake of Added Sugar and Sugar-Sweetened Beverages and Their Role in Type 2 Diabetes Risk

It has been suggested that high intake of added sugar and sugar-sweetened beverages (SSBs) increase the level of circulating inflammatory proteins and that chronic inflammation plays a role in type 2 diabetes (T2D) development. We aim to examine how added sugar and SSB intake associate with 136 measured plasma proteins and C-reactive protein (CRP) in the Malmö Diet and Cancer-Cardiovascular Cohort

Composition effects on photooxidative membrane destabilization by TiO2 nanoparticles

Membrane interactions and photooxidative membrane destabilization of titanium dioxide (TiO2) nanoparticles were investigated, focusing on the effects of membrane composition, notably phospholipid headgroup charge and presence of cholesterol. For this, we employed a battery of state-of-the-art methods for studies of bilayers formed by zwitterionic palmitoyloleoylphosphatidylcholine (POPC) containin

Combined two-phase co-flow and counter-flow in a gas channel/porous transport layer assembly

This paper considers a detailed numerical analysis of combined liquid-gas co-flow in a gas channel, with liquid-gas counter-flow in a porous transport layer, as is typically found on the cathode side of a polymer electrolyte fuel cell. The geometry is obtained by digital reconstruction of nano-computer tomography images. From this, the domain is tessellated with an unstructured castellated or octr

Past-tense inflection of non-verbs : a potential clinical marker of developmental language disorder in Swedish children

Aim: In this paper, we explore the performance of past-tense inflection of non-verbs (NVI) in children with developmental language disorder (DLD) and in typically developing controls, to investigate its accuracy as a clinical marker for Swedish-speaking children with DLD. Further, we investigate the relationship between NVI, nonword-repetition, and family history. Methods: The sample consists of 3

Metal residues in macroalgae feedstock and implications for microbial fermentation

Macroalgae cultivation shows potential for the application as emerging feedstock for microbial fermentation to produce biochemicals. However, metal residues in macroalgae might affect the fermentation capacity of relevant microorganisms. This aspect is currently not considered when selecting macroalgae and microorganism species for microbial fermentation. To consider this aspect for selecting viab

Deuterium-Enhanced Raman Spectroscopy for Histidine pKa Determination in a pH-Responsive Hydrogel

We report here a method for the determination of the pKa of histidine in complex or heterogeneous systems amenable to neither solid-state nor solution NMR spectroscopy. Careful synthesis of a fluorenylmethyloxycarbonyl- and trityl-protected, C2-deuterated histidine produces a vibrational-probe-equipped amino acid that can readily be incorporated into any peptide accessible by standard solid-phase

Long-term outcome after early repair of complete atrioventricular septal defect in young infants

Objective: The long-term outcome after repair of complete atrioventricular septal defect in young infants is still not fully understood. The objective of this study was to evaluate data after repair for complete atrioventricular septal defect over a 25-year period to assess survival and identify risk factors for left atrioventricular valve–related reoperations. Methods: A total of 304 consecutive

RIFM fragrance ingredient safety assessment, ethyl lactate, CAS registry number 97-64-3

The existing information supports the use of this material as described in this safety assessment. Ethyl lactate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data on ethyl lactate show that ethyl lactate is not genotoxic and provided a calculated Margin of E

Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer : population-based study

Background: Papillary thyroid cancer is treated with total/near-total thyroidectomy (TT) with or without central lymph node dissection (CLND), depending on risk factors and tumour size. Balancing the risk of disease recurrence and surgical morbidity remains a challenge. A population-based nationwide study was undertaken to evaluate the risk of permanent hypoparathyroidism associated with CLND. Met

Which future path to pick? A contingency approach to omnichannel warehouse configuration

Purpose: Recent studies have highlighted the importance of adopting a contingency approach to configuring omnichannel warehouses. Nonetheless, research on how various contextual factors influence the selection of warehouse configuration is scarce. This study fills this knowledge gap by exploring how and why certain configurations fit in different omnichannel contexts. Design/methodology/approach:

Strong 5f Ferromagnetism in UH3-Based Materials

Several diverse types of UH3-based hydrides can be prepared by hydrogenation of bcc U-based alloys. Pair Distribution Function (PDF) analysis using high-energy X-rays identified that the (UH3)1-xMo x hydrides are nanocrystalline, with the structure motif based mainly on the β-UH3 structure. α-UH3 represents a minority component. On the other hand, PDF of the (UH3)1-xZr x hydrides corresponds well