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Intracellular lipid-binding proteins contain a large binding cavity filled with water molecules. The role played by these water molecules in ligand binding is not well understood, but their energetic and dynamic properties must be important for protein function. Here, we use the magnetic relaxation dispersion (MRD) of the water 17O resonance to investigate the water molecules in the binding cavity

An automated high-performance liquid chromatographic (HPLC) method has been developed for measurement of 5-S-cysteinyl-DOPA in urine (DOPA = 3,4-dihydroxyphenylalanine). The urinary sample was injected into an HPLC boronate column. With a mobile phase of 0.1 M phosphate buffer containing 0.2 mM disodium ethylenediaminetetraacetate (Na2EDTA) (pH 6.0) mixed with methanol (9:1), 5-S-cysteinyl-DOPA wa

Popular Abstract in Swedish Köpenhamnsevangeliariet skrevs och illuminerades i England omkring år 1000, och intar en viktig position i konsthistorien genom sina ikonografiska likheter med det 300 år äldre Lindisfarneevangeliariet. I föreliggande avhandling behandlas handskriften i sin helhet med avseende på dess framställning och senare historia, men den huvudsakliga analysen rör bildernas stilistThe subject of this thesis is the Copenhagen Gospel Book , written and illuminated in England c 970 with additions from c 1020. The thesis is divided into three main parts focusing on different aspects of the manuscript. The first part deals with problems concerning provenance, palæography, later additions and the physical architecture of the manuscript. The author questions the opinion that the m

By providing nest boxes, previous studies have shown that nest sites are in short supply and limit the populations of several small passerines, including the Great Tit Parus major, the Blue Tit P. caeruleus, and the Pied Flycatcher Ficedula hypoleuca. Can this influence their distribution over a range of small woodland patch sizes in a heterogeneous landscape? To investigate this, a study was cond

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia encountered in clinical practice, accounting. Recent findings highlight the need for better characterisation of the arrhythmia in each patient, in order to improve patient treatment. The main objective of this work was to characterise atrial electrophysiology with respect to AF by means of non-invasively obtained data. Spectra

Popular Abstract in Swedish Avhandlingen utgår från den förändring som ägt rum i Europa det senaste decenniet, med skiftet från ”welfare” till ”workfare” eller aktiveringspolitik. Vissa forskare hävdar att denna politik är den enda möjligheten till inklusion i arbetsmarknaden, för dem som är exkluderade. Andra hävdar att endast den universella välfärdsstaten kan leda till det resultatet. AvhandlinThe thesis aims to discuss if activation policies can support the inclusion of immigrant women and men into the Swedish labour market.A paradigmatic change in welfare policies has taken place in Europe during the last decade with the shift from welfare to workfare or activation policies. Some researchers claim that, for those excluded from the labour force, activation policies are the only way to

With the human genome in a first sequence draft and several other genomes being finished this year, the existing information gap between genomics and proteomics is becoming increasingly evident. The analysis of the proteome is, however, much more complicated because the synthesis and structural requirements of functional proteins are different from the easily handled oligonucleotides for which a f

Picolinic acid (PA) protects against quinolinic acid- and kainic acid-induced neurotoxicity in the brain. To study the uptake of PA to the brain, we administered [H-3]PA via a unilateral nasal instillation or iv injection to mice. Autoradiography demonstrated a rapid uptake of radioactivity in the olfactory nerve layer and in the ipsilateral olfactory bulb (OB) following nasal instillation of [H-3

The isoscalar dipole (compression) mode is studied first using the schematic harmonic-oscillator model, and then the self-consistent Hartree-Fock (HF) and random-phase approximation (RPA) are solved in coordinate space. Taking Pb-208 and the SkyM* interaction as a numerical example, the spurious component and the strength in the continuum are carefully examined using the sum rules. It is pointed o

This report describes the derivation of a nonlinear model of a tractor-semitrailer combination vehicle. The purpose of the model is validation of yaw-control algorithms. The model include 4 DOF in lateral, longitudinal, and yaw motion. It is formulated as a state-spece model with 5 state variables. Additional states are added with the rotational dynamics of the wheels. The model includes a static

A scoring system could be used in all situations where grading of deep leg vein thrombosis (DVT), including mapping of its distribution, is needed. It should also be used in epidemiological studies of DVT in further analysis of different risk groups suffering from DVT. Several scoring systems have been developed during the last three decades but have resulted in various complex and impractical sys

Popular Abstract in Swedish Resenärernas värderingar av kvalitet i lokal kollektivtrafik – hur man kan mäta dem, hur de varierar och hur man kan använda dem i planeringen Syftet med arbetet har varit att ta fram ett mer detaljerat underlag för planering av lokal kollektivtrafik. Med mer kunskap om hur olika grupper av resenärer värderar olika delar av en kollektivtrafikresa kan kollektivtrafiknätThe aim of this work was to get a more detailed basis for planning of local public transport. With more knowledge of how segments of travellers assess different parts of a journey, bus routes can be planned to fit either all passengers or selected groups better. It will also be possible to evaluate perceived travel utility separately for each category of passengers. Stated Preference questionnaire