Increased levels of inflammatory mediators such as cystenyl leukotrienes (CysLT) have been found in and around tumors. These data, along with our previous observation that the G-protein-coupled receptor CysLT(1)R, which signals survival and proliferation, is up-regulated in colon cancer, suggest an important role for CysLT(1)R in tumor development. The objective of this study was to examine the ex

The fine-structure splitting of the 42D state in lithium was measured using stepwise laser excitation combined with level-crossing spectroscopy. The splitting was determined to be 456.2(0.8) MHz, a considerably higher value than the one obtained in a recent level-anticrossing measurement. The new value is in good agreement with the result of a Hartree-Fock calculation, 460.2 MHz.

Optimizing pharmacokinetic/pharmacodynamic indices of antibiotics to obtain clinical and microbiological efficacy is essential, but dosing regimens must also be tailored to minimize the risk for emergence of resistance. The aim of the present study was to investigate whether certain concentrations of benzylpenicillin are critical for the selection of resistant subpopulations. A mixed culture of St

Streptococcus pneumoniae isolates of serotypes 1, 4, 6B, 7F, 14, and 19F belonging to clonal types with known invasive disease potential in humans were used to infect C57BL/6 and BALB/c mice. Most isolates were able to colonize the nasopharynx for 7 days. One serotype 19F isolate of the clonal type ST162 had higher bacterial numbers than other isolates and clonal types of the same serotype. Seroty

This report is the thesis of the research and development project entitled: Development of a Resource Saving Concept for the Establishment of a Climate Suitable for the Storage of Objects Worthy of Preservation in Storerooms at Museums and in Archives. In short: The ZEPHYR project. This work is the result of a research and development project. The aim is to improve the possibilities of using pass

In a Northern country such as Sweden, energy use in the home may be reduced by 20% through changes in behaviour. However, little is known about how households respond to policy instruments encouraging such change or to what degree this in turn may affect the workload of women and men in such communities. The current study presents findings from interviews with 30 households in Sweden that particip

The Saccharomyces cerevisiae leukotriene A4 (LTA4) hydrolase (scLTA4 hydrolase) has been crystallized in order to study the two activities of LTA4 hydrolase in an evolutionary perspective. Single well diffracting crystals are obtained after switching from the hanging-drop method to liquid-liquid diffusion in capillaries using PEG 8000 as precipitant. These crystals belong to space group P212121, w

Vid de nivåer av PSA (prostataspecifikt antigen) där en botbar prostatacancer eventuellt skulle kunna diagnostiseras är godartad prostataförstoring vanligare än cancer. Urinvägsinfektioner ger ofta en påtaglig och långvarig ökning av PSA. Vid undersökningsfynd eller symtom som inger misstanke om prostatacancer ska PSA alltid analyseras. Screening med PSA för tidig diagnostik av prostatacancer utvä

BACKGROUND: Diabetes type 1 is associated with an increased risk for infant congenital malformations. It is debated whether this is true also at gestational diabetes. AIMS: To study occurrence of congenital malformations in infants whose mothers had preexisting or gestational diabetes. STUDY DESIGN: A register study covering over 1.2 million Swedish births in 1987-1997 based on the Swedish health

Fifty eight enterococcal isolates from wild herbivores were tested for their antibiotic sensitivity pattern and lectin-like binding of extracellular matrix (ECM) and serum proteins. Kanamycin resistance was very frequent; many multiresistant strains were also isolated. All isolates were sensitive to rifampicin. Resistance to gentamicin, novobiocin, and tetracycline was widely distributed in the mi

Abstract is not available

Recension av Paul Hallberg (red.), Per Nyström. Motor i 1900-talets svenska sociala och samhällsekonomiska utveckling. Symposion den 10 november 2003 med anledning av Per Nyströms födelse.

Urbanisation and industrialisation has led people spending more time indoors than ever before. Many buildings have small windows and contain large windowless spaces. Therefore, the natural daylight outdoors has to be replaced by light from artificial sources. If light affected vision only, this situation would be difficult enough. Since light also affects both well-being and health, the design of

Within the RISING (Rare ISotope INvestigations @ GSI) Collaboration at GSI, g factor measurements have been performed on isomeric states in neutron-rich isotopes approaching Sn-132 and in the neutron deficient Pb-region (the g-RISING campaign). We present the experimental technique and some typical aspects related to such studies on relativistic beams selected with the FRS fragment separator. Firs

With the increasing capacity in today's hardware system design enabled by technology scaling, image processing algorithms with substantially more complexity can be implemented in a single chip with real-time performance. Combined with the demand for low power consumption or larger resolution seen in many applications such as mobile devices and HDTV, new design methodologies and hardware architectu

High-spin states in Sb-106 have been investigated in the Fe-54(Ni-58, 1α 1p1n) reaction by in-beam γ-spectroscopic methods using the EUROBALL detector array equipped with charged particle and neutron detectors. On the basis of measured γγ-coincidence relations, angular distributions, and linear polarization ratios a significantly extended level scheme has been constructed up to spin and parity I-π