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Modernization in a northern fringe of Europe : historical archaeology of early modern Sweden

The Atlantic world looms large in discussions of how the modern world emerged, and what modernization was about; but there have been calls to engage with these topics from the perspective of ‘margins’. Covering large areas of Fennoscandia, the seventeenth-century Kingdom of Sweden represented a northern end of urban Europe, but also encompassed the mythical Lapland, homeland of the Sámi and of nat

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Food encodes social and cultural values and has an important role to play in defining identities. In mixed populations, diet can be used to distinguish between ‘us’ and ‘them’. This study investigates the extent to which the inhabitants of mediaeval Tallinn, an important trading centre, used food to maintain distinct identities. Human skeletal material was selected from four mediaeval cemeteries i

Coronary and Carotid Imaging of Atherosclerosis and Contributing Factors in Middle-aged People with Long-term Cervical and Upper Thoracic Spinal Cord Injuries

INTRODUCTION: Cardiovascular disease (CVD) is a major cause of death in people aging with spinal cord injury (SCI), and is predominantly caused by atherosclerosis, however, knowledge of atherosclerosis in people with SCI is scarce.OBJECTIVE: To describe coronary and carotid atherosclerosis in middle-aged people with long-term cervical and upper thoracic SCI using coronary computed tomography angio

A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer

Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug resistance remains a significant issue, with almost half of patients ultimately relapsing. Elucidating the mechanisms that control ERα function may furth

A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk

PURPOSE: Ductal carcinoma in situ (DCIS) patients and their physicians currently face challenging treatment decisions with limited information about the individual's subsequent breast cancer risk or treatment benefit. The DCISionRT biological signature developed in this study provides recurrence risk and predicts radiotherapy (RT) benefit for DCIS patients following breast-conserving surgery (BCS)

Pulmonary embolism and deep venous thrombosis after COVID-19 : long-term risk in a population-based cohort study

Background: Venous thromboembolism (VTE) (pulmonary embolism [PE] or deep venous thrombosis [DVT]) is common during acute COVID-19. Long-term excess risk has not yet been established. Objectives: To study long-term VTE risk after COVID-19. Methods: Swedish citizens aged 18 to 84 years hospitalized and/or testing positive for COVID-19 between January 1, 2020, and September 11, 2021 (exposed), strat

Navigating the COVID-19 pandemic: Learning experiences of an online Sino-Nordic doctoral summer school on aging

The COVID-19 pandemic has accelerated the digital transformation of Higher Education, necessitating a rapid shift from in-person to remote teaching and learning. This study investigates the experiences of doctoral students in an online Sino-Nordic summer school on aging, implemented during the pandemic. A survey was conducted to collect and analyze data on participants’ experiences and perspective

Direct observation of secondary nucleation along the fibril surface of the amyloid β 42 peptide

Alzheimer's disease is a neurodegenerative condition which involves heavy neuronal cell death linked to oligomers formed during the aggregation process of the amyloid β peptide 42 (Aβ42). The aggregation of Aβ42 involves both primary and secondary nucleation. Secondary nucleation dominates the generation of oligomers and involves the formation of new aggregates from monomers on catalytic fibril su

Ovärdig vård i livets slutskede – verklighetens palliativa vård?

En ökad kunskap och medvetenhet i vården och i samhället om palliativa vårdbehov skulle ge våra medborgare en bättre och tryggare tillvaro i livets slutskede.I den vård som bedrivs när livet närmar sig sitt slut saknas ofta – planering för vården i livets slutskede trots multisjuklighet och hög ålder– brytpunktssamtal eller informerande samtal med närstående – dokumentation av patienters behov, ön

Curriculum for training in endoscopic mucosal resection in the colon : European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

Main recommendations: Endoscopic mucosal resection (EMR) is the standard of care for the complete removal of large (≥ 10mm) nonpedunculated colorectal polyps (LNPCPs). Increased detection of LNPCPs owing to screening colonoscopy, plus high observed rates of incomplete resection and need for surgery call for a standardized approach to training in EMR. 1 Trainees in EMR should have achieved basic co

Matching-adjusted indirect comparison of bleeding outcomes in severe haemophilia A : Comparing valoctocogene roxaparvovec gene therapy, emicizumab prophylaxis, and FVIII replacement prophylaxis

Introduction: Head-to-head evaluation of valoctocogene roxaparvovec, the first gene therapy approved for haemophilia A, with emicizumab is not available. Therefore, phase 3 trial data were indirectly compared. Aim: To compare bleeding rates in trials evaluating 6 × 1013 vg/kg valoctocogene roxaparvovec (GENEr8-1; NCT03370913), 1.5 mg/kg emicizumab dosed every week (HAVEN 3; NCT02847637), and FVIII

Did the Eurasian ice sheets melt completely in early Marine Isotope Stage 3? New evidence from Norway and a synthesis for Eurasia

We describe glaci-lacustrine sediments buried under thick tills in Folldalen, south-east Norway, a site located close to the former centre of the Scandinavian Ice Sheet. Thus, the location implies that the ice sheet had melted when the sediments were deposited. The exposed ground was occupied by arctic vegetation. The best age estimate from 20 quartz luminescence dates is 55.6 ± 4.6 ka. Due to pos

Så kan AI valideras för klinisk implementering

Företag marknadsför över 200 mjukvaror för artificiell intelligens (AI) inom radiologi.Vårdgivare behöver ha möjlighet till opartisk och kvalitetssäkrad utvärdering.Projektet Validering av AI inom bröst­radio­­­logi (VAI-B) startades för att möta detta behov, initialt inom mammografi­screening.

TODLER : A Transaction Ordering Dependency anaLyzER - for Ethereum Smart Contracts

Smart contracts are programs with data (mutable state); stored on and executed by blockchain platforms. The transactions (or function invocations) dispatched to smart contracts often change their state. In the Ethereum blockchain, nodes (aka miners/validators) can schedule a set of transactions in any order in a block. Multiple transactions in a single block operating on a contract's shared state

Managing harmful floor emissions including 2-ethylhexanol by using an emissions barrier

The present communication describes the use of an emissions barrier to prevent spread of hydrolysis products from plastizisers in plastic mats and from the glue used to attach such mats onto a concrete slab. In particular, 2-ethylhexanol was focussed at. Elevated air concentrations of 2-ethylhexanol has been associated with a range of health symptoms such as e.g. cough, airways irritation, fatique