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The Problem of Fit in Flood Risk Governance: Regulative, Normative, and Cultural-Cognitive Deliberations

Flood risk is a growing global concern that is not only affecting developing countries, but also the sustainable development of the most affluent liberal democracies. This has attracted attention to the systems governing flood risk across administrative levels, which vary between countries, but are relatively similar in the Nordic region, with both responsibilities and resources largely decentrali

Suicide Attempt in Patients With Gambling Disorder—Associations With Comorbidity Including Substance Use Disorders

Background: Gambling disorder is known to be associated with increased risk of suicidal behavior. However, relatively little is known about how the risk of suicide attempts in gambling disorder is influenced by comorbid alcohol or drug use disorders, as well as other psychiatric conditions. Methods: The present study is a nationwide, diagnostic register study assessing the risk of suicide attempts

PP038. Renal ETK/BMX activation decreased in preeclampsia

INTRODUCTION: Vascular endothelial growth factors (VEGF's) are essential to angiogenesis and play a central role in the pathophysiology of preeclampsia. Specifically, antagonists of VEGFR2 cause a preeclampsia-like syndrome, in humans and rats[1]. ETK/BMX is a receptor tyrosine kinase (RTK) which induces VEGF expression and forms a complex with VEGFR2, whereby VEGF and TNF can induce a reciprocal

In adults with obesity, copeptin is linked with BMI but is not associated with long-term exposure to cortisol and cortisone

Context: Obesity and cardiometabolic diseases are associated with higher long-term glucocorticoid levels, measured as scalp hair cortisol (HairF) and cortisone (HairE). Cardiometabolic diseases have also been associated with copeptin, a stable surrogate marker for the arginine-vasopressin (AVP) system. Since AVP is, together with corticotropin-releasing hormone (CRH) an important regulator of the

Pricing Activities : Bridgeing the Performativity - Coordination Divide in Economic Sociology

A fundamental question for economic sociology is: how are prices set? In economic sociological theory, a price is generally conceptualized either in terms of the performative construction of economy (e.g. a market device), or in terms of co-ordinational effects of power relations between buyers and sellers (e.g. the effect of social structures and institutions). In this paper, I set out to show ho

In the evening, I don’t walk in the park”: Perceived design qualities, safety and neighbourhood walkability

Introduction. Walking as a means of transportation is central in sustainable urban design. Little focus has, however, been placed on the influence of micro-level environmental features, such as vegetation and street lighting, on perceived safety and walking.Method. This study applied a non-explicit approach to explore the impact of greenery and outdoor lighting on neighborhood walkability. Partici

Adipose cell size changes are associated with a drastic actin remodeling

Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies have shown that enlarged, hypertrophic adipocytes are less responsive to insulin, and that adipocyte size could serve as a predictor for the devel

PTPD : Predicting therapeutic peptides by deep learning and word2vec

Background In the search for therapeutic peptides for disease treatments, many efforts have been made to identify various functional peptides from large numbers of peptide sequence databases. In this paper, we propose an effective computational model that uses deep learning and word2vec to predict therapeutic peptides (PTPD).∗: Results Representation vectors of all k-mers were obtained through wor

A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome

A single bout of electroacupuncture results in muscle contractions and increased whole body glucose uptake in women with polycystic ovary syndrome (PCOS). Women with PCOS have transcriptional and epigenetic alterations in the adipose tissue and we hypothesized that electroacupuncture induces epigenetic and transcriptional changes to restore metabolic alterations. Twenty-one women with PCOS receive