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Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glyc

Background Lifestyle exposures play a major role in the development of disease, yet people vary in their susceptibility. A critical step towards precision medicine is identifying individuals who are resilient or sensitive to the environment, and, assess whether the allocation to these predicted groups are more or less likely to develop cardiometabolic disease.Methods We have used repeated data fro

Cocaine- and amphetamine-regulated transcript (CART) is mostly known for its appetite regulating effects in the central nervous system. However, CART is also highly expressed in the peripheral nervous system as well as in certain endocrine cells. Our group has dedicated more than 20 years to understand the role of CART in the pancreatic islets and in this review we summarize what is known to date

Evidence of the impact of the COVID-19 pandemic on health behaviours in the general population is limited. In this retrospective longitudinal study including UK and US participants, we collected diet and lifestyle data pre-pandemic (896,286) and peri-pandemic (291,871) using a mobile health app, and we computed a bidirectional health behaviour disruption index. Disruption of health behaviour was h

This chapter discusses the value of a capability approach in historical research on older people. Historians are generally focused on studying continuity and change over time. Their research often aims at explaining how and why certain phenomena appear and take different shapes. Capability is a way of capturing an individual’s ability to live a meaningful life, or a life that they perceive as good

Diabetes is a complex and multifactorial disease that affects millions of people worldwide, reducing the quality of life significantly, and results in grave consequences for our health care system. In type 2 diabetes (T2D), the lack of β-cell compensatory mechanisms overcoming peripherally developed insulin resistance is a paramount factor leading to disturbed blood glucose levels and lipid metabo

In the last few years, the traditional analysis of know as a factive verb has been lively debated by linguists and philosophers of language: several scholars have pointed out that know may be used non-factively in ordinary language. The aim of the present study is to expand this inquiry to other cognitive factive verbs than know, such as discover, realize, etc., and to investigate cross-linguistic

Syfte: Cancerforskning och relaterade innovationsprocesser saknar ofta en viktig komponent; patientdeltagande. Vi nyanalyserar tre studier (a-c) för att undersöka hur teorin Nuets förnöjsamhet kan användas för att förbättra patientens deltagande och psykosociala hälsa.Metod: Vi återanalyserade data från den klassiska grundade teoristudien om Nuets förnöjsamhet, baserad på fyra års observation och Purpose: Cancer research and connected innovation processes often lack a major component; patient participation. We revisit three studies (a-c) in order to explore how Momentary contentment theory may be used to improve patient participation and psychosocial health.Method: We revisited data from the initial (a) classic grounded theory study on Momentary contentment, based on four years of observat

Current sustainability assessment (SA) tools to help deal with contaminated groundwater sites are inherently subjective and hardly applied. One reason may be lack of proper tools for addressing contaminant spread which are basically objective. To fill this gap, there is a need for contaminant transport models that provide site managers with needed room for applying their judgments and consideratio

Incorporating time as a unit of analysis can enrich the study of agency by showing the specific ways in which actors are temporally constrained when responding to economic disturbances. In this paper, this is done by examining how the behavior of actors is affected by timing norms such as term limits that may be associated with an actor's position, as for example, an elected mayor or university vi

This study explores journalistic routines during the corona pandemic, with the aim of contributing to the hitherto sparse area of research focusing on the pandemics impact on journalism. Previous research emphasizes the complexity of news production and editorial work, and testifies to the variety of possible theoretical perspectives when studying journalistic routines. To enable a broader underst

Bakgrund: Covid-19-pandemin har förändrat utbildningsformen på universitet Sverige över, vilket påtvingat distansstudier för många studenter. Omställningen kan inverka på studenters upplevelse av aktivitetsbalans, vilket är kopplat med hälsa och välbefinnande, men det saknas idag studier inom detta fält. Ökad kunskap om hur studenter upplever distansundervisningens inverkan på deras aktivitetsbala

Offentlig upphandling är ett verktyg som har stor påverkan på marknaden på grund av dess stora köpkraft. EU vill använda den offentliga upphandlingen för att kunna uppnå en grön offentlig upphandling. EU antog 2010 en strategi som kallas för Europa 2020-strategin. Med den strategin bestämde sig EU för att uppnå vissa klimatmål. Grön offentlig upphandling skulle hjälpa till att uppnå de målen. Som Public procurement is a tool that has a major impact on the market due to its large purchasing power. The EU wants to use this tool to achieve a green public procurement. In 2010, the EU adopted a strategy called the Europe 2020 strategy. With that strategy, the EU committed to pursue certain climate goals. Green public procurement would help achieve those goals. As part of the strategy, a new dir

This thesis is placed in the context of talent management and revolves around the phenomena of talent and talent wars. The two phenomena have received increased attention in the talent management discourse during the last decades as the international competitiveness for talents among organizations has become amplified. The purpose of this thesis has been to explore, analyze and compare different p

Rätten att söka och åtnjuta asyl har fastställts genom FN:s allmänna förklaring om de mänskliga rättigheterna. Bedömningen av vem som anses vara flykting ska utföras i enlighet med kriterier och normer som återfinns inom internationell såväl som regional och nationell lagstiftning. I asylmål är det inte ovanligt med svårigheter att hitta bevis som styrker den sökandes utsaga. Istället läggs stor vThe right to seek refuge has been established by the the Universal Declaration of Human Rights. The rules and criteria which regulates the assessment of refugee claims can be found on an international, regional and national level. Lack of evidence is not an uncommon problem in refugee cases. Instead, credibility assessments becomes crucial. Well-functioning methods and criteria needs to be applied