Search results

Objective: The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. Methods: As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes.

Clinically relevant weight loss is achievable through lifestyle modification, but unintentional weight regain is common. We investigated whether recently discovered genetic variants affect weight loss and/or weight regain during behavioral intervention. Participants at high-risk of (Diabetes Prevention Program [DPP]; N=917/907 intervention/comparison) or with (Look AHEAD; N=2,014/1,892 interventio

Cocaine and amphetamine-regulated transcript (CART) is an islet peptide that promotes glucose stimulated insulin secretion in beta cells via cAMP/PKA-dependent pathways. In addition, CART is a regulator of neuronal survival. In this study, we examined the effect of exogenous CART 55-102 on beta cell viability and dissected its signaling mechanisms. Evaluation of DNA fragmentation and chromatin con

In this thesis, two questions are answered: What is burnout?, and What causes burnout? Essentialist conceptions of burnout are criticized and burnout is regarded as a syndrome in the sense of a practice concept, not possible to delineate exactly. Practice concepts are compared to social constructions. From the syndrome idea, the Maslach Burnout Inventory (MBI), is chosen as an operationalization o

The central issue of the dissertation is the place and meaning of the concepts transitional object (TO) and transitional phenomenon (TP) as defined by Winnicott, in a normal psychological context. A group of children were followed from age 8 months to 6 years. A prevalence study was carried out by interviewing parents in connection with the child's (n=147) routine check-ups at the Child Health Cen

Improving electrical efficiency has been proposed as the most convenient means of reducing, e.g. CO₂ emission from power plants. Increasing fuel utilization through combined heat and power generation is another useful measure for emission reduction. Trigeneration technology for the production of heat, power and cooling is an interesting alternative for further improvement of fuel utiliz

Josef Bexell as soul-carer Josef Bexell (1815–1897), Lutheran rector of Långaryd in the diocese of Växjö, was widely known as a soul-carer, both in public and in private. His sermons were not only heard in Church, but circulated and read in private, and questions from his private soul-care were answered in public preaching. The private soul-care was performed both in private encounters and in lett

Several studies have found that organic farms support higher biodiversity, but results vary between studies such that some also show no or even negative effects. There can be many reasons why studies comparing organic and conventional farming show conflicting results. The efficacy of organic farming can depend on focal taxa, landscape context, study scale and the proportion of organically managed

This paper is a component of a three-year empirical study of gaming moms undertaken with the aim to modulate the conventional constructions of gamer identities and examine the contested status of gaming in everyday life. It presents samples of mothers in gaming discourse – from TV, Music-video, forums, and ads. Mothers have been largely invisible in popular gaming discourse or formulaically portra

Universal Design is a design principle that has been in recent years gaining growing prevalence in the design of physical and social environments and product innovation. Universal Design is referred to as the process of creating products, services, and environments for people with a wide range of (dis)abilities and other characteristics, without special adaptation ‘to the greatest extent possible.

Genom att använda sig av dendrokronologi kan man skapa högupplösta klimatarkiv från subfossila trädrester. Från torvtäkten Ope-Brynjeflon i Jämtland har 178 holocena prover av tall (Pinus sylvestris) hämtats för att användas i klimatrekonstruktioner. Syftet med den här studien är att fortsätta det redan påbörjade arbetet med att anlysera proverna för att (1) ta reda på över hur lång tid och vilket

The purpose of this paper is to investigate what motivates the recidivism discrepancy between populations with: severe psychiatric disorder and non-severe psychiatric disorder. The aim is to introduce an argument for biopsychosocial influences as underlying an individual’s propensity to act, using Luhmannian systems theory. By making use of current research on social and neurological risk factors,

Dealing with difficult conversations is recognised as being one of the most challenging aspects of the managerial role. Scholarly research within this field is primarily normative in its nature where difficult conversations are still poorly understood from managers’ point of view. This thesis aimed to explore and analyse how middle managers perceive difficult one-on-one conversations in terms of t

Under sen darriwil-tid i mellanordovicium var Baltica täckt av ett grundhav med relativt rikt och varierat djurliv. Under årmiljoner avsattes här sediment som kom att omvandlas till kompakta kallvattens-karbonater. Baserat på fältstudier och punkträkning av sex stycken tunnslip har den omkring 10 meter mäktiga ”furudalkalkstenen” vid Kårgärdeprofilen (Dalarna, Sverige) analyserats med avseende på

Syfte: Syftet var att undersöka huruvida svensktalande barn med språkstörning (developmental language disorder, DLD) uppvisar en preferens för rak SV-ordföljd, undersöka hur distributionen av rak och omvänd XVS-ordföljd förändras över tid, och jämföra antalet förekomster av den ogrammatiska XSV-strukturen hos barnen med språkstörning jämfört med barn med typisk språkutveckling. Metod: Ortografiska