Lysande protein ska hjälpa spåra ändringar vid alzheimers sjukdom Demens är ett syndrom som påverkar en stor del av populationen vid högre ålder. Syndromet yttrar sig genom att påverka personers kognitiva förmågor, huvudsakligen minnet. Frekvensen kommer fortsätta att öka med den åldrande populationen. Den vanligaste och mest välkända varianten av demens är alzheimers sjukdom. Som alla vet är deApolipoprotein E4 (ApoE4) is the biggest genetic risk factor for Alzheimer’s disease. While it is known to transport cholesterol to neurons the localization of the protein has not yet fully been mapped. Levels of amyloid precursor protein (APP) and its cleavage product amyloid beta (Aβ), the main component of amyloid plaques, in transfected cells were determined using western blot. Green fluoresce

The purpose of this qualitative secondary analysis is to study how victims of sex trafficking are illustrated in previous research. 16 peer reviewed articles have been analysed based on a hermeneutic approach. The results of previous research are consistent: The society has a narrow view of victims, and a more complex, intersectional understanding of the victimhood is required. The victims` storie

Karlshamnsverket är ett kraftverk som ligger vid Östersjön i södra Sverige. På grund av placeringen vid kusten har denna viktiga infrastruktur redan tidigare varit utsatt för översvämningar i källaren. Syftet med föreliggande studie är att genomföra en första analys för att fastställa de bakomliggande orsakerna till översvämningarna och att föreslå lämpliga åtgärder för att öka kraftverkets motst

På gränsen mellan Helsingborgs och Bjuvs kommun ligger ett område vars förutsättningar för grundvattenuttag bedöms vara dåliga. Av den anledning har en undersökning utförts över en förkastning, tolkad av SGU i just detta område, för att se om denna kan vara vattenförande eller om det kan finnas andra vattenförande strukturer i berget. Förkastningen och det omkringliggande området har undersökts me

”Den svenska familjerättsliga regleringen speglar i många avseende grundläggande värderingar i samhället, oavsett om de funnits där under en lång tid eller om de framkallats av lagstiftningen. Det är här fråga om en växelverkan mellan lagar och samhällsvärderingar. Vår reglering är en produkt av vårt samhälle – vi präglas av regleringen och präglar den.” Professor Anna Singer presenterade citatet

Offentlig upphandling är ett verktyg som har stor påverkan på marknaden på grund av dess stora köpkraft. EU vill använda den offentliga upphandlingen för att kunna uppnå en grön offentlig upphandling. EU antog 2010 en strategi som kallas för Europa 2020-strategin. Med den strategin bestämde sig EU för att uppnå vissa klimatmål. Grön offentlig upphandling skulle hjälpa till att uppnå de målen. Som Public procurement is a tool that has a major impact on the market due to its large purchasing power. The EU wants to use this tool to achieve a green public procurement. In 2010, the EU adopted a strategy called the Europe 2020 strategy. With that strategy, the EU committed to pursue certain climate goals. Green public procurement would help achieve those goals. As part of the strategy, a new dir

This thesis is placed in the context of talent management and revolves around the phenomena of talent and talent wars. The two phenomena have received increased attention in the talent management discourse during the last decades as the international competitiveness for talents among organizations has become amplified. The purpose of this thesis has been to explore, analyze and compare different p

Background: Prediction tools that combine polygenic risk scores with clinical factors provide a new opportunity for improved prediction and prevention of atherosclerotic cardiovascular disease, but the clinical utility of polygenic risk score has remained unclear. Methods: We collected a prospective cohort of 7342 individuals (64% women, mean age 56 years) and estimated their 10-year risk for athe

The formation of metamorphic zircon after baddeleyite is a well-known reaction that can be used to date the metamorphism of igneous silica-undersaturated rocks. By contrast, metamorphic minerals formed after igneous zirconolite have rarely been reported. In this paper, we document metamorphic titanite + zircon pseudomorphs formed from the metamorphic breakdown of igneous zirconolite in syenodiorit

Human genetic variation in PPARGC1B has been associated with adiposity, but the genetic variants that affect PPARGC1B expression have not been experimentally determined. Here, guided by previous observational data, we used CRISPR/Cas9 to scarlessly edit the alleles of the candidate causal genetic variant rs10071329 in a human brown adipocyte cell line (hBAs). Switching the rs10071329 genotype from

This study investigates the role of multi-stakeholder networks in disaster risk management (DRM) capacity development and how it aligns with the principles of the Sendai Framework for Disaster Risk Reduction. While the Framework emphasises collaboration, coordination, and partnerships among diverse stakeholders, there remains a gap in understanding how networks foster and sustain collaborative DRM

To understand, predict and mitigate climate change, it is crucial to have long-term and standardised measurements of greenhouse gas concentrations in the atmosphere and their fluxes between atmosphere, land and oceans. The Integrated Carbon Observation System, is a distributed European Research Infrastructure which provides high-precision and highly standardised observations from more than 170 sta

This article investigates the generation of online representations of older people by institutions. Specifically, it discusses the ways in which public sector organizations generate online representations of older people from a production perspective. This article uses the following questions to frame its analysis: What do we know about online representations of older people generated by public se

BackgroundPostural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate increase on standing and symptoms of orthostatic intolerance, posing significant limitations on functional capacity. No objective tool exists to classify symptom burden in POTS.MethodsWe conducted a case-control study in 62 POTS patients and 50 healthy cont

Social media are increasingly important tools in diplomacy. Diplomats are expected to use social media platforms such as Twitter, Facebook and Instagram to communicate with each other and with both domestic and international publics. This form of communication involves displaying positive emotions to generate attention in a competitive information environment. Emotions are essential to managing pe

As the market share of electric vehicles increases, the need for a charging infrastructure increases correspondingly. Modern Electric Road Systems is a cost effective charging infrastructure that allows electric vehicles to charge while driving and consequently allowing for smaller batteries in EVs. To assess the potential of electric road system technology, a demonstrator of conductive electric r

Apolipoprotein A-I (ApoA-I) amyloidosis is a rare protein misfolding disease where fibrils of the N-terminal domain of the protein accumulate in several organs, leading to their failure. Although ApoA-I amyloidosis is systemic, the different amyloidogenic variants show a preferential tissue accumulation that appears to correlate with the location of the mutation in the protein sequence and with th