Background: The objective of this study was to compare the efficacy of ritonavir boosted atazanavir versus ritonavir boosted lopinavir or efavirenz, all in combination with 2 nucleoside analogue reverse transcriptase inhibitors (NRTIs), over 144 weeks in antiretroviral-naive HIV-1-infected individuals. Methods: A prospective open-label randomized controlled trial was conducted at 29 sites in Swede

IT procurement represents a business process of importance, including the ability to articulate requirements that the procurement deals with. Furthermore, specifying requirements is of importance for both procurer, and potential supplier as it functions as central contractual element between the two. The purpose of the article is to show how functional and non-functional requirements are represent

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising

Dynamic descriptions of static situations, e.g. The road goes through the forest, have attracted a lot of attention in semantics. In cognitive linguistics, terms such as “fictive motion” and “subjective motion” are often used to describe such sentences. While these terms are taken to be largely synonymous, I argue that they are analytically different, and furthermore point to different possible ex

Electronic publishing and institutional archives – a scholarship report from CaliforniaIn June 2005 Linda Gustafsson and Kristina Lindgren had the opportunity to make a one week visit to the library at Caltech University, Pasadena in California. The aim was to see how the library staff worked with e-publishing together with the researchers at the campus. As researchers are an important user group

Introduction: The purpose of the study was to elucidate the association between smoking and estradiol (E2) and testosterone (T) levels in young healthy women from highrisk families. Cigarette smoke contains multiple carcinogens and is considered a risk factor for breast cancer. However, tobacco also contains aromatase inhibiting substances, but the impact on hormonal levels in young women at the a

During inflammation, cellular glucose uptake and glycolysis are upregulated to meet an increased energy demand. For example, keratinocyte glycolysis is essential for progression of psoriasis. Therefore, understanding the regulation of glucose metabolism in keratinocytes is of importance. Here, we show that the pro-inflammatory cytokines IFNγ and TNF together rapidly induce glucose uptake, glycolys

Differential expression of microRNAs (miRNAs) is observed in many diseases including type 2 diabetes (T2D). Insulin secretion from pancreatic beta cells is central for the regulation of blood glucose levels and failure to release enough insulin results in hyperglycemia and T2D. The importance in T2D pathogenesis of single miRNAs in beta cells has been described; however, to get the full picture, h

The COVID-19 pandemic caused universities worldwide, including those in Sweden, to adopt online distance learning as the primary teaching approach. However, there is limited research on how larger environmental changes affect university students’ occupational balance. In this study, 15 university students were interviewed, and their responses were analyzed using qualitative content analysis. The f