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Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle
Neuroblastoma is a pediatric tumor derived from cells in the sympathetic nervous system. In an attempt to explain the heterogeneous clinical behavior of neuroblastoma tumors, neuroblastomas have been characterized with regard to their degree of sympathetic differentiation. Their expression of genes and proteins that regulate normal sympathetic development and cell cycle/cell death regulators was a
C4b-binding protein (C4BP) is an acute-phase plasma glycoprotein which regulates the complement system through its affinity for C4b. In addition, C4BP binds to the anticoagulant protein S and to serum amyloid P component (SAP). Protein S is a vitamin K-dependent protein which looses its anticoagulant properties when binding to C4BP. C4BP is composed of two types of subunits, the a-chain and the b-
The ABO blood group system is undoubtedly the most important genetic and phenotypic marker in clinical transfusion medicine. The A and B determinants are immunodominant, terminally located carbohydrate residues of glycoconjugates on erythrocytes and other cell surfaces. The enzymes responsible for assembly of these structures are glycosyltransferases encoded by the ABO genes on chromosome nine. T
The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding
Background. Polypharmacy is known to increase the risk for drug-related problems, and some drugs, potentially inappropriate medications (PIMs), are especially troublesome. Objective. To analyse the effects on prescription of PIMs of the SäKLäK project, an intervention model created to improve medication safety for elderly patients in primary care. Method. The SäkläK project was a multiprofessional
Purpose: The objective of this study was to compare patients with epiphora and cataract in terms of the activity limitations they experience in daily life due to their visual disability and to validate the use of the Catquest-9SF questionnaire for epiphora patients. Methods: Seventy-two consecutively encountered adult patients with confirmed lacrimal obstruction and listed for dacryocystorhinostom
BACKGROUND: Varus osteotomy of the proximal femur (VOPF) is one treatment option to prevent hip dislocation in children with cerebral palsy (CP). It is questioned whether the osteotomy should be performed in the displaced hip only, or if it should be performed bilaterally to prevent later displacement of the contralateral hip. CPUP is a register and healthcare programme for children with CP that w
The major theme underlying this symposium is the development and growth of many new forms of business associations over the last few decades. These new forms are characterized by a combination of personal freedom from partner/owner liability and far-reaching freedom of contract for partner/owners. The question thus becomes whether this development of new business associations amounts to an extensi
The boreal and boreo-nemoral forests in Europe, which occur in northern and northeastern Europe, are dominated by 2 coniferous species, Norway spruce Picea abies (L.) Karst. being economically the most important one. Forestry is of major economic importance in this region. Forestry planning and climate change scenarios are based on similar (long-term) timescales, i.e. between 70 and 120 yr. Within
