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Unrecognized liver cirrhosis is common and associated with worse survival in hepatocellular carcinoma : A nationwide cohort study of 3473 patients
Patterns of Communication About Serious Illness in the Years, Months, and Days before Death
Selection of Weather Files and Their Importance for Building Performance Simulations in the Light of Climate Change and Urban Heat Islands
Building performance predictions and their reliability rely heavily on weather data inputs. Climate is affected by spatial and temporal differences related to climate change and urban heat island effects, but the weather files used in building performance simulations (BPS) often remain unchanged and may represent weather observations generated from inadequate space and time for their application.
Detection of G Protein-Coupled Receptor Autoantibodies in Postural Orthostatic Tachycardia Syndrome Using Standard Methodology
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a disorder of orthostatic intolerance that primarily affects women of childbearing age. The underlying pathophysiology of POTS is not fully understood, but it has been suggested that autoimmunity may play a role. The aim of this study was to compare concentrations of autoantibodies to cardiovascular G protein-coupled receptors between
Prevalence and treatment of hip displacement in children with cerebral palsy in Finland
Purpose: The aim was to study the prevalence of hip displacements, dislocations, and the hip surgeries performed in a Finnish cohort of children with cerebral palsy not followed up in a hip surveillance program and to compare these with previous studies performed in Northern European countries before and after the implementation of hip surveillance programs.Methods: A cross-sectional study. A coho
Validity and clinical utility of the obsessive compulsive inventory - Child version : Further evaluation in clinical samples
Background: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder. Currently, the Obsessive Compulsive Inventory-Child Version (OCI-CV) is the only self-report measure that fully captures this symptom heterogeneity in children and adolescents. The psychometric properties of the OCI-CV are promising but evaluations in large clinical samples are few. Further, no studies have exa
Characterisation and monitoring of in-situ remediation of chlorinated hydrocarbon contamination using an interdisciplinary approach (MIRACHL)
To meet future challenges in urban development with denser housing and sustainable water resources, society needs to take actions. Densification of housing is met by expanding housing into old industrial areas often contaminated and water resources are already affected in some areas by over exploiting, pollutants spreading and a changing climate leading to changes in recharge.Growing concerns are
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD-02 study design and first results
Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testin
Levothyroxine treatment and incident dementia in adults with atrial fibrillation
Lifestyle and cancer incidence and mortality risk depending on family history of cancer in two prospective cohorts
Immunoassay-based quantification of full-length peptidylglycine alpha-amidating monooxygenase in human plasma
A one-step sandwich chemiluminescence immunometric assay (LIA) was developed for the quantification of bifunctional peptidylglycine-α-amidating monooxygenase (PAM) in human plasma (PAM-LIA). PAM is responsible for the activation of more than half of known peptide hormones through C-terminal α-amidation. The assay employed antibodies targeting specific catalytic PAM-subunits, peptidylglycine alpha-
Local Government Bodies as Parties to Contracts
Ex vivo and in vivo experimental investigation of miR-148a-3p as a novel therapy for insulin secretion and type 2 diabetes
Mortality risks associated with sibling heart failure
Ways of knowing school mathematics
Sex-based differences in ED management of critically ill patients with sepsis : a nationwide cohort study
Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk : The GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol
Introduction The POInT study, an investigator initiated, randomised, placebo-controlled, double-blind, multicentre primary prevention trial is conducted to determine whether daily administration of oral insulin, from age 4.0 months to 7.0 months until age 36.0 months to children with elevated genetic risk for type 1 diabetes, reduces the incidence of beta-cell autoantibodies and diabetes. Methods
