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1. During incubation of platelets with 3H-arachidonic acid (20:4, n-6) and 14C-cholesterol doubly labelled and colloidal gold labelled chylomicrons (CMs) and chylomicron remnants (CMRs) CMs were taken up more efficiently than CMRs. Addition of unlabelled CMs, VLDLs, LDLs and HDLs decreased the uptake of labelled CMs. Electron microscopic studies demonstrated an accumulation of CM-Au's both in the

The Baltic Sea is one of the world’s largest brackish water environments and is today suffering from, for example, eutrophication, spreading hypoxia, accumulations of contaminants and invasive organisms. These problems exist due to a combination of natural features that makes the Baltic Sea a sensitive ecosystem (such as long water residence time, limited water exchange, large catchment area), and

The purpose of this paper is to explore in what way the place becomes important for those who are affected by disasters or sudden death. According to human geography people have affective bonds to the concrete physical places where they are living and moving in their everyday live. Places are also constructed as meeting places where people create social relations. In the discotheque fire in Gothen

Purpose: The purpose is to provide insight into how companies in practice work during packaging development to reduce negative environmental impacts along supply chains and to compare their practical approaches with the theoretical concepts presented in the literature. Design/methodology/approach: The research approach is explorative and based on nine cases (26 semi-structured interviews) in the f

Patients waiting for cardiac surgery often consider the period from the decision for surgery to the time for the operation as long, heavy and dreary. Therefore, it is important that patients are supplied with structured oral and written information regarding their disease and its treatment, so that they are able to understand and discuss the forthcoming operation, the risk of complications and the

GBV-C/HGV is a blood-borne virus related to the hepatitis C virus. We studied GBV-C/HGV infection in different populations, its transmission, and its association with liver disease. GBV-C/HGV viraemia was detected by PCR in 19/576 blood donors. Donors with normal and elevated ALT levels had similar rates of viraemia (1.6% vs. 4.1%; p = 0.20). Signs of resolved GBV-C/HGV infection (anti-E2 antibodi

The homologous blood coagulation factors V (FV) and factor VIII (FVIII) are important at sites of vascular injury for the amplification of the clotting cascade. Activated FV (FVa) serves as a cofactor to the enzyme activated factor X (FXa) in the activation of prothrombin. This complex is called the prothrombinase complex. FVIII functions as a cofactor to the enzyme activated factor IX (FIXa) in t

The thesis deals with models for molybdopterin-dependent enzymes. Several model systems containing molybdenum or tungsten have been prepared and characterised, and their reactivity with oxygen atom acceptors and donors have been investigated. Oxygen atom transfer reactions involving oxomolybdenum bis-dithiolene complexes have been modelled using density functional calculations. The first molybden

A suicide attempt is one of the most powerful predictors of eventual suicide. The aim of this thesis was to investigate the social situation, including social support of suicide attempters. One part of the investigations concerned patients admitted to a psychiatric ward following a suicide attempt. Another part concerned significant others (SOs) of suicide attempters, interviewed directly after th

The aim with this thesis was to investigate effects of vasoactive mediators on mucociliary activity and blood flow in rabbit and human experimental models. Mucociliary activity in vivo and ciliary beat frequency (CBF) in vitro were measured with photoelectric techniques. Blood flow was measured with laser Doppler flowmetry. Substance P (SP) and methacholine increased human nasal blood flow. Pretre

The aim of this dissertation is to use intersectional analysis to investigate how gender is made in drug abuse treatment and to examine how the formation of gender interplays with the formation of sexuality, class and ethnicity. Central questions are: What gender(s) are to be shaped in druge abuse treatment? What happens to a gender perspective with emancipatory ambitions when it is incorporated i

Boken innehåller en grekisk text (baserad på cod. Athos Protaton 86) utgiven av Britt Dahlman och en svensk översättning av den systematiska samlingen av Apophthegmata Patrum (Ökenfädernas tänkespråk), bok 6. Översättningen har gjorts gemensamt av deltagarna i översättningsseminariet vid Johannesakademin.

Aggressive lymphoma is a rapidly growing tumour of lymphocyte origin, potentially curable with chemotherapy. In a trial by the Nordic Lymphoma Group, 405 patients with aggressive lymphoma were included, and randomised to receive either the standard chemotherapy regimen, CHOP, or a weekly multidrug regimen, MACOP-B. In this trial, MACOP-B was not superior in terms of response, failure-free or overa

Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that

Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). The major objectives of this investigation was to establish a role for TNF-a in the development of atherosclerosis and neointimal formati

The importance of early detection of brain changes during ageing has been recognised. Single photon emission computed tomography (SPECT) is a method used for estimation of cerebral blood flow (CBF) in clinical work and in research. The aim of thesis was to study CBF in demented and non-demented elderly persons with special reference to blood pressure changes. Elderly women with senile dementia of