In an uncertain and ambiguous world, organizations need to find new ways to manage change and stay in business. Constantly changing environmental policies and corporate climate action puts even more pressure on organizations in change management. It is apparent that corporate climate action shapes the way companies operate a business. Hence, the purpose of the present study is to shed light on man

Investeringar i transportinfrastruktur medför normalt bättre tillgänglighet, bättre läge, eventuellt ökad byggrätt och en ökning av värdet på de fastigheter som är belägna i närheten av den infrastruktur som anläggs. Värdeökningar som uppstår till följd av offentliga investeringar bör genom värdeåterföring ges tillbaka till det offentliga. En värdeåterföringsmetod är medfinansieringsersättning somInvestments in infrastructure normally lead to better accessibility, a better location, increased building rights and an increase in the value of the properties that are located near to the infrastructure. Increases in value that arise as a result of public investments should be returned to the public sector through value capture. A value capture method is co-financing compensation which according

Sverige har både idag och historiskt sett haft en stark aktiebolagsrättslig lagstiftning. Framför allt gagnar denna starka lagstiftning aktieägarens rättigheter i förhållande till aktiebolaget som entitet. Vid sidan av den aktiebolagsrättsliga lagstiftningen ligger avtalsrätten. Där båda områdena faller inom civilrätten, är dessa regelverk nära förankrade med varandra. Aktiebolagsrätten är menad a

Background: Acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) are common early-onset malignancies. Their causes are largely unknown but infectious etiology has been implicated. Type 1 diabetes (T1D) is an autoimmune disease for which infectious triggers of disease onset have been sought and increasing pointing to enteroviruses. Based on our previous results on co-morbidity betwee

Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT.

There is limited information regarding new ulceration following the healing of ischaemic foot ulcers in diabetic patients. Our aim is to study new ulcerations in the same foot as the previous ulcer(s) in patients with diabetes and severe peripheral artery disease (PAD).

Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.

Birth after caesarean section (CS) is an issue of growing importance. As a consequence of increasing CS rates, more women having experienced a prior CS will need counselling about preferred second delivery mode. There are two choices: elective repeat caesarean section (ERCS) or trial of labour (TOL). It is well known, that a TOL ending in an emergency CS carries the largest risks for mother and ch

Sight-threatening diabetic retinopathy has been treated with photocoagulation for decades but the mechanisms behind the beneficial clinical effects are poorly understood. One target of irradiation and a potential player in this process is the retinal pigment epithelium (RPE). Here we establish an in vitro model for photocoagulation of human RPE cells.

Diabetes mellitus is one of the most common endocrine disorders in dogs and is commonly proposed to be of autoimmune origin. Although the clinical presentation of human type 1 diabetes (T1D) and canine diabetes are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported.

Background: rs10993994, a single nucleotide polymorphism (SNP) at the genetic locus encoding beta-microseminoprotein (beta-MSP), is associated with both prostate cancer risk and levels of blood prostate-specific antigen (PSA), a biomarker used in prostate cancer screening. Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate

The overall aim of this thesis was to study how persons experience the influence of Rheumatoid Arthritis (RA) on their sexual health and their experiences of communication about sexual health, in order to improve physiotherapy within the field of rheumatology. Sexual health is an integrated part of life, and persons with Rheumatoid Arthritis, RA, often experience a decreased sexual health, which c

We tested whether characteristic changes of the plasma lipidome in individuals with comparable total lipids level associate with future cardiovascular disease (CVD) outcome and whether 23 validated gene variants associated with coronary artery disease (CAD) affect CVD associated lipid species.