INTRODUCTION: We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples. METHODS: We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB p

In type 2 diabetes (T2D), hepatic insulin resistance is strongly associated with nonalcoholic fatty liver disease (NAFLD). In this study, we hypothesized that the DNA methylome of livers from patients with T2D compared with livers of individuals with normal plasma glucose levels can unveil some mechanism of hepatic insulin resistance that could link to NAFLD. Using DNA methylome and transcriptome

Accurate diagnosis of rare inherited anaemias is challenging, requiring a series of complex and expensive laboratory tests. Targeted next-generation-sequencing (NGS) has been used to investigate these disorders, but the selection of genes on individual panels has been narrow and the validation strategies used have fallen short of the standards required for clinical use. Clinical-grade validation o

The Sardinian dhole (Cynotherium sardous) was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene. Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African hunting doThe Sardinian dhole (Cynotherium sardous)1 was an iconic and unique canid species that was endemic to Sardinia and Corsica until it became extinct at the end of the Late Pleistocene.2-5 Given its peculiar dental morphology, small body size, and high level of endemism, several extant canids have been proposed as possible relatives of the Sardinian dhole, including the Asian dhole and African huntin

BACKGROUND AND AIMS: This study aimed to expand the European Prospective Investigation into Cancer and Nutrition (EPIC) nutrient database (ENDB) by adding amino acid (AA) values, using the U.S. nutrient database (USNDB). Additionally, we aimed to evaluate these new protein and AA intake estimates from the EPIC dietary questionnaires (DQ) and 24-h dietary recalls (24-HDR) using different matching p

Scenarios are a useful tool to help think about and visualise the future and, as such, are utilised by many policymakers and practitioners. Future scenarios have not been used to explore the urban context in much depth, yet have the potential to provide valuable insights into the robustness of decisions being made today in the name of sustainability. As part of a major research project entitled Ur

Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that

OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+)

The SCHOLAR-2 retrospective study highlighted poor overall survival (OS) with standard of care (SOC) regimens among patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL) who failed a covalent Bruton tyrosine kinase inhibitor (BTKi). In the ZUMA-2 single-arm trial, brexucabtagene autoleucel (brexu-cel; autologous anti-CD19 CAR T-cell therapy) demonstrated high rates of durable response

Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory

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To go to a specific year directly, please click on the year here: 2024, 2023, 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, 2013, 2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005, 2004, 20032024 Valeria Governa, Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Svenja Offer, Myriam Cerezo-Magaña, Jiaxin Li, Sarah Beyer, Maria C Johansson, Ann-Sofie Månsson, Charlotte Edvardsson, Faris Durmo,

https://www.molecular-neurogenetics.lu.se/publications - 2025-02-19

The current Jägersro horse racetrack in southeast Malmö will be replaced with apartments. Alongside this area Skånska Travsällskapet plans to build a new Jägersro Horse Center on their private land. They wish the center to be Europe's most prominent with a focus on sustainability. In July 2024, the first building is planned to be inaugurated, which is assumed to be subscribed for a power ratin

Vattnets plats i staden är en fråga som vinner allt mer mark i den svenska samhällsdebatten. Malmö drabbades i augusti 2014 av ett häftigt skyfall som ledde till översvämningar som orsakade stora problem både för privatpersoner och samhället. Förhoppningarna med den nya väderradartekniken är att konsekvenserna av ett sådant skyfall i framtiden inte ska bli lika omfattande. Under sommaren 2018 satThroughout history it has always been crucial to accurately measure, track, and predict precipitation. This has been done using various methods with varying degrees of precision. As the world evolves and as urban areas expand, it has become more apparent that there is a need for a more efficient way to observe and record precipitation. During the summer of 2018, an X-band weather radar located in

On the July 1, 2020, a new framework of rules regarding reportable arrangements was introduced in Sweden and at the same time a reporting obligation to give information about reportable arrangements to the Swedish Tax Agency (STA) was introduced. For an arrangement to be reportable it must be cross-border and include at least one hallmark. A hallmark is a characteristic in an arrangement which is

Syftet med denna uppsats är att utreda rättsläget för barn som häktas och därefter diskutera hur det förhåller sig till barns särskilda skyddsvärde i straff- och straffprocessrätten. Jag diskuterar och reflekterar även över lagstiftningens eventuella brister, behov av förändring och förbättring samt hur förändringar och förbättringar i sådana fall skulle kunna te sig lämpliga utifrån ett barnrättsThe purpose of this thesis is to investigate the legal position for children being detained and discussing how that relates to children’s particular protective value in penalty- and criminal procedure law. I am also discussing and reflecting on the legislation’s eventual flaws, need of change and improvement and how changes and improvements in those cases could be appropriate from a perspective of

The Swedish Government has recently initiated additional permit-free buildings with the aim to simplify the Planning and Building act, reduce the housing shortage and increase a property owner’s proprietorship. According to the amendment it is possible to construct a complementary home with the size of 25 square meters in close proximity to an existing house. This building is known as an Attefall

Den svenska sexualbrottslagstiftningen har genomgått stora förändringar över åren. Våldtäktsbestämmelsen har på olika sätt utvidgats och tvångskravet har sänkts med tiden. Syftet har delvis varit att förstärka och tydliggöra rätten till sexuellt självbestämmande och sexuell integritet. Detta är två begrepp som har varit återkommande i sexualbrottslagstiftningen under senare år. Trots detta har tvåThe Swedish legislation on sexual offences has been subject to major changes over the years. The provision of rape has in various ways been extended and the coercion requirement has been reduced over time. The purpose of the changes has partly been to strengthen and clarify the sexual integrity and self-determination – two concepts that have been recurring in the legislation on sexual offences in

Till följd av finanskrisen förlorade konsumenter genom placeringar i riskfyllda finansiella instrument stora delar av sina investeringar. Under åren 2008 och 2009 inkom fler klagomål till Finansinspektionen och Konsumentverket jämfört med tidigare år om att många konsumenter via rådgivning rekommenderats produkter som inte motsvarat den risk de varit beredda att ta eller att information om risken The aftermath of the financial crisis meant that many consumers lost parts of their investments because they had invested their savings in risky financial instruments. Between the years of 2008 and 2009, the Swedish Financial Supervisory Authority, Finansinspektionen, and the Swedish Consumer Agency, Konsumentverket, received more complaints, compared to previous years, regarding financial advisor