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BACKGROUND Nivolumab was associated with higher rates of objective response than chemotherapy in a phase 3 study involving patients with ipilimumab-refractory metastatic melanoma. The use of nivolumab in previously untreated patients with advanced melanoma has not been tested in a phase 3 controlled study. METHODS We randomly assigned 418 previously untreated patients who had metastatic melanoma w
Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non–insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15–20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identificat
Akademikerföreningen vid Siemens Energy AB | Hoppa till huvudinnehåll Öppna sökruta Öppna Huvudmeny Sök på saco.se Om oss Stadgar Kollektivavtal Bli medlem Nyheter Pensionsföreläsning 15/10-2025 kl.08 Nyhetsbrev Löneskola 2025 Möt ASI-styrelsen över en kopp kaffe Ny styrelsesammansättning ASIs årsmöte 2024 Sommarhälsning Ny försäkring ger stöd vid psykisk ohälsa Presentationsmaterialet från frukos
Introduction: Reporting of hypoglycaemia and its impact in clinical studies is often retrospective and subject to recall bias. We developed the Hypo-METRICS app to measure the daily physical, psychological, and social impact of hypoglycaemia in adults with type 1 and insulin-treated type 2 diabetes in real-time using ecological momentary assessment (EMA). To help assess its utility, we aimed to de
Aims/hypothesis: The aim of this work was to examine the impact of hypoglycaemia on daily functioning among adults with type 1 diabetes or insulin-treated type 2 diabetes, using the novel Hypo-METRICS app. Methods: For 70 consecutive days, 594 adults (type 1 diabetes, n=274; type 2 diabetes, n=320) completed brief morning and evening Hypo-METRICS ‘check-ins’ about their experienced hypoglycaemia a
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i
Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear whether they undergo dynamic r
Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes and mediates water flux across the blood-brain and blood-spinal cord barriers. Here we show that AQP4
Pancreatic islets are complex micro-organs consisting of at least three different cell types: glucagon-secreting alpha, insulin-producing beta and somatostatin-releasing delta cells. Somatostatin is a powerful paracrine inhibitor of insulin and glucagon secretion. In diabetes, increased somatostatinergic signalling leads to defective counter-regulatory glucagon secretion. This increases the risk o
Anemia because of insufficient production of and/or response to erythropoietin (Epo) is a major complication of chronic kidney disease and cancer. The mechanisms modulating the sensitivity of erythroblasts to Epo remain poorly understood. We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (Tf
Acute myeloid leukemia with t(6; 9)(p22; q34) is listed as a distinct entity in the 2008 World Health Organization classification, but little is known about the clinical implications of t(6; 9)-positive myeloid leukemia in children. This international multicenter study presents the clinical and genetic characteristics of 62 pediatric patients with t(6; 9)/DEKNUP214-rearranged myeloid leukemia; 54
Purpose: To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer’s Disease (AD) Research Framework derived from [18F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181). Methods: We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within 18
The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the n
ARAB14 Vt12 Språk- och litteraturcentrum Arabiska LITTERATURLISTA ARAB14, Modern standardarabiska: Grundkurs I (15hp)/ (15 ECTS) ARAB14, Modern Standard Arabic: Intermediate Course I (15 ECTS) Fastställd av lärarkollegium 5 den 1 november 2011 ------------------------------------------------------------------------------------------------------------- Delkurs 1. Tidningstext I, 15 hp Ashtiany, Jul
https://www.sol.lu.se/media/utbildning/dokument/kurser/ARAB14/20121/ARAB14.pdf - 2025-09-19
Microsoft Word - föreskrifter rektorsbeslut Postadress Box 7080 220 07 Lund Besöksadress Ekonomicentrum, Tycho Brahes väg 1 Telefon 046-222 81 34 E-post kristina.arnrup_thorsbro@ehl.lu.se Rektor Lunds universitets föreskrifter för studentkårers redovisning av verksamhet och medlemsantal Bakgrund Enligt 4 kap 14 § högskolelagen (1992:1434) ska studentkårer årligen till högskolan redovisa sin verksa
Microsoft Word - HILMA 2008-03-14.doc HILMA Historiska Institutionen i Lund Meddelar Att… Årgång 33, 2007/08, Nr 10, 2008-03-14 Underlagen till HILMA förvaras i pärmar som står i rum 209, på hyllan ovanför faxen. Där hittar du ytterligare information om seminarier, anställningsvillkor, stipendier och annat samt ansök- ningsblanketter i förekommande fall. De sistnämnda, som är samlade i en separat
https://www.hist.lu.se/fileadmin/_migrated/content_uploads/hilma_vt08_20.pdf - 2025-09-18
2020 1995 Trust, a Core Condition Malmö Art Academy 25 Years M a lm ö A r t A c a d e m y , F a c u lt y o f F in e a n d P e r f o r m in g A r t s , L u n d U n iv e r s it y Trust, a Core Condition 1 2 3 4 5 6 7 8 9 10 11 12 5 11 22 37 47 59 83 99 115 128 145 173 181 192 Foreword Timeline Studio Visits Matts Leiderstam Concentric Pedagogy: Towards an Ethics of the Observer Mary Kelly Collective
https://www.khm.lu.se/sites/khm.lu.se/files/2021-01/201106_maa25_digi_LQ.pdf - 2025-09-19
Syftet med den här uppsatsen är att ur ett civilrättsligt perspektiv undersöka hur de svenska civilrättsliga reglerna skyddar någon som riskerar att utsättas för barn- och tvångsäktenskap, samt olika myndigheters agerande och förhållningssätt när de möter någon som befinner sig i riskzonen för påtvingade äktenskap. En stor del av de äktenskap som ingås mot någons vilja berör parter som bor i oliThe purpose of this paper is to examine from a civil law perspective how the Swedish legislation protect anyone at risk for child and forced marriages, as well as how various government agencies intervene and approach situations when they meet someone who is at risk of forced marriage. A large part of the marriage entered against someone's will affect parties who live in different countries.
The Swedish Government has recently initiated additional permit-free buildings with the aim to simplify the Planning and Building act, reduce the housing shortage and increase a property owner’s proprietorship. According to the amendment it is possible to construct a complementary home with the size of 25 square meters in close proximity to an existing house. This building is known as an Attefall
Vattnets plats i staden är en fråga som vinner allt mer mark i den svenska samhällsdebatten. Malmö drabbades i augusti 2014 av ett häftigt skyfall som ledde till översvämningar som orsakade stora problem både för privatpersoner och samhället. Förhoppningarna med den nya väderradartekniken är att konsekvenserna av ett sådant skyfall i framtiden inte ska bli lika omfattande. Under sommaren 2018 satThroughout history it has always been crucial to accurately measure, track, and predict precipitation. This has been done using various methods with varying degrees of precision. As the world evolves and as urban areas expand, it has become more apparent that there is a need for a more efficient way to observe and record precipitation. During the summer of 2018, an X-band weather radar located in
